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Binding Characterization Study of the Interaction of an Anticancer Drug Ifosfamide with Bovine Serum Albumin

T.S. Rajendra Kumar1 , M. Uma Mahesh2

  1. Department of Chemistry, Rayalseema University, Kurnool, AP, India.
  2. Department of Chemistry, Rajeev Gandhi Memorial College of Engineering and Technology, Nandyal, India.

Correspondence should be addressed to: tsrajendrakumar2017@gmail.com.


Section:Research Paper, Product Type: Isroset-Journal
Vol.5 , Issue.1 , pp.1-6, Apr-2018


CrossRef-DOI:   https://doi.org/10.26438/ijsrcs/v5i1.16


Online published on May 30, 2018


Copyright © T.S. Rajendra Kumar, M. Uma Mahesh . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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IEEE Style Citation: T.S. Rajendra Kumar, M. Uma Mahesh, “Binding Characterization Study of the Interaction of an Anticancer Drug Ifosfamide with Bovine Serum Albumin,” International Journal of Scientific Research in Chemical Sciences, Vol.5, Issue.1, pp.1-6, 2018.

MLA Style Citation: T.S. Rajendra Kumar, M. Uma Mahesh "Binding Characterization Study of the Interaction of an Anticancer Drug Ifosfamide with Bovine Serum Albumin." International Journal of Scientific Research in Chemical Sciences 5.1 (2018): 1-6.

APA Style Citation: T.S. Rajendra Kumar, M. Uma Mahesh, (2018). Binding Characterization Study of the Interaction of an Anticancer Drug Ifosfamide with Bovine Serum Albumin. International Journal of Scientific Research in Chemical Sciences, 5(1), 1-6.

BibTex Style Citation:
@article{Kumar_2018,
author = {T.S. Rajendra Kumar, M. Uma Mahesh},
title = {Binding Characterization Study of the Interaction of an Anticancer Drug Ifosfamide with Bovine Serum Albumin},
journal = {International Journal of Scientific Research in Chemical Sciences},
issue_date = {4 2018},
volume = {5},
Issue = {1},
month = {4},
year = {2018},
issn = {2347-2693},
pages = {1-6},
url = {https://www.isroset.org/journal/IJSRCS/full_paper_view.php?paper_id=568},
doi = {https://doi.org/10.26438/ijcse/v5i1.16}
publisher = {IJCSE, Indore, INDIA},
}

RIS Style Citation:
TY - JOUR
DO = {https://doi.org/10.26438/ijcse/v5i1.16}
UR - https://www.isroset.org/journal/IJSRCS/full_paper_view.php?paper_id=568
TI - Binding Characterization Study of the Interaction of an Anticancer Drug Ifosfamide with Bovine Serum Albumin
T2 - International Journal of Scientific Research in Chemical Sciences
AU - T.S. Rajendra Kumar, M. Uma Mahesh
PY - 2018
DA - 2018/05/30
PB - IJCSE, Indore, INDIA
SP - 1-6
IS - 1
VL - 5
SN - 2347-2693
ER -

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Abstract :
The interaction between Ifosfamide (IFO) and bovine serum albumin (BSA) has been studied. The studies were carried out in a buffer of medium at pH 7.4 using fluorescence spectroscopy, UV-vis spectroscopy, and Viscometric methods. The results of fluorescence quenching and UV-vis absorption spectra experiments indicated the formation of the complex of BSA-IFO. Binding parameters were determined using the Stern-Volmer equation. From fluorescence and UV-vis spectroscopic data, the binding constant between IFO and BSA was calculated to be 4.275 x 103 L mol-1 and 8.173 x 103 L mol-1 respectively. The results of thermodynamic parameters ∆G˚, ∆H˚ and ∆S˚ at different temperature indicate that the electrostatic interactions and also hydrogen bonds play a major role for IFO-BSA association.

Key-Words / Index Term :
Ifosfamide, BSA, UV-visible, Fluorescence, viscometry

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