Semaglutide and Obesity: Real-World Clinical Applications and Outcomes

Swati Sucharita Dash¹ , Merlin Roshma Sherin² , Debalina Das³ , Guruprasad KS Rao⁴

1. Real-World Evidence & Health Economics and Outcome Research, Molecular Connections Analytics Pvt. Ltd., Heritage Building, B - Block, #59/2, Kaderanahalli, Outer Ring Rd, Banashankari Stage II, Bengaluru, Karnataka 560070.
2. Real-World Evidence & Health Economics and Outcome Research, Molecular Connections Analytics Pvt. Ltd., Heritage Building, B - Block, #59/2, Kaderanahalli, Outer Ring Rd, Banashankari Stage II, Bengaluru, Karnataka 560070.
3. Real-World Evidence & Health Economics and Outcome Research, Molecular Connections Analytics Pvt. Ltd., Heritage Building, B - Block, #59/2, Kaderanahalli, Outer Ring Rd, Banashankari Stage II, Bengaluru, Karnataka 560070.
4. Real-World Evidence & Health Economics and Outcome Research, Molecular Connections Analytics Pvt. Ltd., Heritage Building, B - Block, #59/2, Kaderanahalli, Outer Ring Rd, Banashankari Stage II, Bengaluru, Karnataka 560070.

Section:Research Paper, Product Type: Journal-Paper
Vol.11 , Issue.1 , pp.1-14, Mar-2024

Online published on Mar 31, 2024

Copyright © Swati Sucharita Dash, Merlin Roshma Sherin, Debalina Das, Guruprasad KS Rao . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Obesity, a chronic and complex disease, is projected to have a prevalence of 49% by 2030 and is linked to various comorbidities, including type 2 diabetes, hypertension, dyslipidemia, stroke, coronary heart disease, and cancers, resulting in a substantial economic burden. Effective weight management is crucial to reduce morbidity and mortality. Semaglutide, initially developed as a GLP-1 receptor agonist for treating type 2 diabetes, is now being explored for its potential in addressing obesity. Its utilization is expanding to chronic weight management as it mimics the effects of GLP-1, regulating blood sugar levels and appetite. The FDA approved the use of a 2.4 mg injection of semaglutide once weekly for chronic weight management. Semaglutide proves efficacy for weight loss in obesity, endorsed by STEP trial findings and real-world data, with safety akin to GLP-1RA class, promoting long-term adherence. Its notable effects on albuminuria, HbA1c, heart failure, and quality of life herald a transformative paradigm in obesity and associated comorbidity management. Through a review of existing literature and clinical studies, this article provides a nuanced overview of the diverse real-world scenarios where semaglutide has been applied, elucidating its impact on weight management and associated health outcomes.

Key-Words / Index Term :
Obesity, Weight loss, Semaglutide, Real-world, GLP-1RA

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