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• Open Access   Article

  Pharmacological Potential of TiO2 Nanoparticles synthesized by Chemical and Green method – A Comparative study

  Natarajan Sampathkumar, Ananthaparavasar Swetharnayam

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.2 , pp.1-6, Apr-2024

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  Abstract
  In modern times, nanoparticles have materialized as indispensable things in contemporary medicine, with variety of uses in clinical, drug and gene conveyance. In the current study, TiO2 nanoparticles prepared from the leaf extracts of Mollugo oppositifolia and Trianthema portulacastrum were compared with the chemical TiO2–nanoparticles for antibacterial and antioxidant activities. The synthesized TiO2-NPs are assessed for antimicrobial and antioxidant activities. Green TiO2-NPs has an antibacterial effect against Pseudomonas aeruginosa (17 + 0.56 mm) and Staphylococcus aureus (16 + 0.24 mm) at concentrations as low as 100 µl. TiO2-NPs Green showed high inhibition of DPPH I radical (50 µg/m) at 95.17 ± 21. Therefore, TiO2-NPs represent eco-friendly properties that aid in the degradation of dyes due to their antioxidant activity.

  Key-Words / Index Term
  Nanoparticles, Mollugo oppositifolia, Trianthema portulacastrum, Antioxidants, Phyto-active compounds, TiO2, antibacterial

  References
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  Citation
  Natarajan Sampathkumar, Ananthaparavasar Swetharnayam, "Pharmacological Potential of TiO2 Nanoparticles synthesized by Chemical and Green method – A Comparative study," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.2, pp.1-6, 2024

• Open Access   Article

  Spectroscopic analysis of Crescent Island Crater sand from Lake Naivasha, Kenya by XRF, FT-IR and XRD

  Ndung’u Samuel Ng’ang’a, Nthiga Esther Wanja, Wanjau Ruth Nduta

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.2 , pp.7-10, Apr-2024

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  The present work investigates the chemical properties of natural sand obtained from Crescent Island Crater in Lake Naivasha catchment, Kenya. Fourier Transform Infra-Red (FT-IR), X-Ray Fluorescence (XRF) and X-Ray Diffraction (XRD) spectroscopic analysis was performed. The XRD results showed that quartz (SiO2), calcite (CaCO3), clinochlore ((Mg, Fe)6(Si, Al)4O10(OH)8)) and microcline (K (Al, Fe) Si3O8) are the main components of the raw sand. The XRF analysis confirmed that silica (SiO2), reaching upto 66.89 ± 0.41 % was the main component of the sand sample with very low quantities of CaO, Fe2O3, MgO, K2O and Al2O3 (< 10 %). The FT-IR results corroborate the presence of siloxane (Si-O-Si) as an important functional group of quartz in the raw sand sample. The findings of the study reveals that the sand from the region is an important resource for sourcing quartz as a primary material for vast industrial applications.

  Key-Words / Index Term
  Crescent Island Crater, XRD, Quartz, XRF, Sand, FT-IR

  References
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  Citation
  Ndung’u Samuel Ng’ang’a, Nthiga Esther Wanja, Wanjau Ruth Nduta, "Spectroscopic analysis of Crescent Island Crater sand from Lake Naivasha, Kenya by XRF, FT-IR and XRD," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.2, pp.7-10, 2024

• Open Access   Article

  Ecofriendly Synthesis and Characterization of Glucoside Derivatives and Its Biological Evaluation

  Nilesh B. Jadhav, Pawan P. Kalbende, Sandip B. Chaudhari, Ramesh T. Parihar

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.2 , pp.11-18, Apr-2024

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  Abstract
  Ethyl 2-imino-6-methyl-4-substituted phenyl-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate compounds [4a-g] were achieved via a one pot multicomponent reaction of ethyl acetoacetate, substituted aromatic aldehyde with guanidine. The reaction is efficiently endorsed to give the preferred products in high yields and in a moderately short time. The resulted pyrimidine derivatives [4a-g] were treated with 2, 3, 4, 6-tetra-O-acetyl-?-D-glucopyranosyl bromide, potassium hydroxide mixed into 1 gm of neutral alumina in solvent free microwave condition furnished a (2S, 3S, 4R, 5S)-2-(acetoxymethyl)-6-((5-(ethoxycarbonyl)-4-methyl-6-phenyl-1, 6-dihydropyrimidin-2-yl)amino) tetrahydro-2H-pyran-3,4,5-triyl triacetate [5a-g]. The resulted products be deacetylated using methanol and ammonia furnished a Ethyl 6- (substituted phenyl) -4- methyl -2- (((3S, 4R, 5R, 6S)-3, 4, 5-trihydroxy -6- (hydroxyl methyl) tetra hydro-2H-pyran-2-yl) amino)-1,6-dihydropyrimidine-5-carboxylate[6a-g]. The molecular structures of the novel synthesized compounds were revealed based on their spectral analysis and elemental analysis. The purity of all synthesized compounds was resoluted by TLC. In addition, preferred derivatives of the products were screened for antimicrobial activity and there in vitro antioxidant activity. The antioxidant activity of the resulted products was also examined and most of them exhibited potent activity.

  Key-Words / Index Term
  Guanidine, Pyrimidine, Glucoside, antimicrobial activity, antifungal activity, antioxidant activity.

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  Citation
  Nilesh B. Jadhav, Pawan P. Kalbende, Sandip B. Chaudhari, Ramesh T. Parihar, "Ecofriendly Synthesis and Characterization of Glucoside Derivatives and Its Biological Evaluation," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.2, pp.11-18, 2024

• Open Access   Article

  Study of Alginate-Glycerin Microspheres for Release Profile of Human Serum Albumin at Different pH Values

  Ahmed Salisu, Zuhra Muhammad Dikko, Ibrahim Usman Gafai

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.2 , pp.19-23, Apr-2024

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  Abstract
  In this study, alginate-glycerin microspheres encapsulated with human serum albumin (HSA) as a model protein were synthesized utilizing the ionotropic gelation process with calcium ions acting as a cross-linker. The encapsulated microspheres were then tested for release profile using the Bradford method in simulated gastric and intestinal fluids (SGF and SIF). The native alginate and the encapsulated microspheres were characterized by FTIR analysis. The results demonstrated that the encapsulated microspheres displayed the gradual release profile of HSA in the simulated gastric fluid (SGF) compared to release profile obtained in simulated intestinal fluid (SIF), that revealed cumulative release of 46 ?g/ml of the model protein over a period of 2 hours’ incubation time. Furthermore, the in cooperated glycerin molecules improved the stability and sustained the released of the HSA in simulated intestinal fluid. In conclusion, the encapsulated microspheres demonstrated promising applications as intestinal-targeted protein vehicles.

  Key-Words / Index Term
  Alginate, Protein, Delivery, Glycerin, microspheres, pH-values

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  Citation
  Ahmed Salisu, Zuhra Muhammad Dikko, Ibrahim Usman Gafai, "Study of Alginate-Glycerin Microspheres for Release Profile of Human Serum Albumin at Different pH Values," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.2, pp.19-23, 2024