Volume-10 , Issue-4 , Dec 2023, ISSN 2349-3178 (Print), 2349-3186 (Online) Go Back

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  Testicular Zinc, Sperm Parameters and Redox Balance in Ethanol-Induced Reproductive Dysfunction Treated With D-Ribose-L-Cysteine

  Omiyale Olumakinde Charles, Akubude Arinze, Edema Biola Victoria, Obasi Ebubechi Daniel, Owusu-Ansa Sarah, Morphy Regina Ekaji, Okafor Stanley Chukwudi, Onuh Chijioke Kenneth, Kokelu Anthony Nduka, Amamba Chinyere Blessing, Adi Ngozichukwu, Aboh Awhobiwom Jacqueline, Didigwu Kenneth Obinna

  Research Paper | Journal-Paper (IJMSRP)

  Vol.10 , Issue.4 , pp.1-12, Dec-2023

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  Abstract
  This study explores the impact of alcohol, a widely abused substance, on the reproductive system, particularly testicular function. The investigation introduces the question of whether concurrent administration of D-Ribose-L-Cysteine supplement (Cellgevity) can mitigate the detrimental effects of alcohol on the testes. The primary objectives involve assessing the influence of D-Ribose-L-Cysteine on testicular zinc levels, spermatogenesis, and redox balance. The experiment employed 20 Sprague Dawley rats, distributed into 4 groups, each consisting of 5 rats: a control group without ethanol or cellgevity, an Alcohol group subjected to ethanol induction only, a Cellgevity group receiving cellgevity only, and an Alcohol plus Cellgevity group exposed to ethanol while concurrently treated with cellgevity. The study duration was 14 days for each group. Results revealed noteworthy alterations in oxidative stress markers. The Alcohol group exhibited a statistical decrease in Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH), and an increase in Malondialdehyde (MDA) and serum zinc concentration. Conversely, the Alcohol plus Cellgevity group demonstrated a statistical increase in SOD, CAT, GSH, and a decrease in MDA and serum zinc concentration. The study also explored sperm parameters, indicating a statistical decrease in sperm motility and morphology in the Alcohol group compared to the Alcohol plus Cellgevity group. However, sperm concentration remained unaffected. In conclusion, ethanol administration adversely affects various aspects of male reproductive functions, including sperm motility, morphology, and testosterone levels, alongside disturbances in trace elements within the testes and increased oxidative stress. Notably, D-Ribose-L-Cysteine administration, as represented by Cellgevity, exhibited a beneficial effect on male reproductive functions. It mitigated oxidative stress, prevented a significant reduction in testicular zinc levels even after ethanol induction, and presented a potential avenue for safeguarding male reproductive health in the face of alcohol-induced stressors.

  Key-Words / Index Term
  Alcohol, D-Ribose-L-Cysteine, Reproductive system, Spermatogenesis, Oxidative stress, Testicular zinc, Sprague-Dawley rats.

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  Citation
  Omiyale Olumakinde Charles, Akubude Arinze, Edema Biola Victoria, Obasi Ebubechi Daniel, Owusu-Ansa Sarah, Morphy Regina Ekaji, Okafor Stanley Chukwudi, Onuh Chijioke Kenneth, Kokelu Anthony Nduka, Amamba Chinyere Blessing, Adi Ngozichukwu, Aboh Awhobiwom Jacqueline, Didigwu Kenneth Obinna, "Testicular Zinc, Sperm Parameters and Redox Balance in Ethanol-Induced Reproductive Dysfunction Treated With D-Ribose-L-Cysteine," International Journal of Medical Science Research and Practice, Vol.10, Issue.4, pp.1-12, 2023