Bisalbuminemia: Insights into its Clinical Manifestations, Diagnostic Complexities, and Relevance in Modern Medicine

Pawan Kumar¹

Section:Research Paper, Product Type: Journal-Paper
Vol.11 , Issue.4 , pp.11-14, Dec-2024

Online published on Dec 31, 2024

Copyright © Pawan Kumar . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Bisalbuminemia, also known as alloalbuminemia, is a rare hematologic disorder characterized by the presence of two distinct serum albumin fractions in the blood. This condition is typically benign and asymptomatic, but its discovery can be puzzling for clinicians due to its rarity and often incidental nature. The occurrence of bisalbuminemia can be hereditary or acquired, with the hereditary form being passed down in an autosomal dominant fashion, while the acquired form is linked to liver disease, kidney disease, or drug exposure. The condition is most commonly identified during routine serum protein electrophoresis (SPE) testing, when an unusual albumin pattern is observed. In this report, we present a case of a patient diagnosed with bisalbuminemia. We discuss the clinical presentation, diagnostic challenges, and management strategies, emphasizing the importance of considering rare hematologic conditions in patients presenting with unexplained hypoalbuminemia and abnormal serum protein electrophoresis results. This case underscores the need for awareness of such conditions among clinicians and laboratory personnel to avoid unnecessary testing and misdiagnoses.

Key-Words / Index Term :
Bisalbumenia, hematologic disorder, hypoalbuminemia, serum protein electrophoresis

References :
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