Antifungal activity of Salacia oblonga extracts Against Human Pathogen Candida albicans

Anjaneyulu Musini¹ , Bhargavi Pokala² , Zahoorullah.S.MD ³ , Prathima Yeddanapalli⁴ , Jahnavi Manchella⁵

Section:Research Paper, Product Type: Isroset-Journal
Vol.5 , Issue.6 , pp.220-223, Dec-2018

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v5i6.220223

Online published on Jan 01, 2018

Copyright © Anjaneyulu Musini, Bhargavi Pokala, Zahoorullah.S.MD, Prathima Yeddanapalli, Jahnavi Manchella . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Salacia Oblonga shrub belonging to the family ‘Celestraceae’. It is found in India and Srilanka. We have collected the plant extract from Western Ghats, India. In traditional medicines it is used for the treatment of diabetes and can be exploited to treat many chronic and infectious diseases. The plant extracts of S.oblonga has been used on the treatment of diabetes, polyuria, gonorrhea, rheumatism, asthma and fever. We have undertaken present study to evaluate the antifungal activity of S.oblonga aerial and root extracts against human pathogen Candida albicans. Antifungal activity of methanol extract (1 mg/ml) and ethyl acetate extracts were tested. Extracts have shown good growth inhibition against Candida albicans. Identified the minimum inhibitory concentration of the plant extract 40µg/ml comparison with synthetic drug Clotrimazole 60µg/ml. Separation of the phytochemical from the crude extracts by thin layer chromatography and identified the active fraction. Our study highlighted the antifungal activity of Salacia Oblonga extracts.

Key-Words / Index Term :
Salacia oblonga, Antifungal activity, Candida albicans and Chromatography

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