Ameliorating Efficacy of Curcumin on Cadmium Induced Thyroid Dysfunction in Albino Rats

S. Sharma¹ , C. Ahuja²

Section:Research Paper, Product Type: Isroset-Journal
Vol.6 , Issue.1 , pp.187-195, Feb-2019

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v6i1.187195

Online published on Feb 28, 2019

Copyright © S. Sharma , C. Ahuja . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Cadmium (Cd) is one of the hazardous heavy metals as it causes various forms of physiological and hormonal imbalances. The aim of the present study was to investigate pharmacological effects of curcumin, a derivative of Curcuma longa Linn., in the prevention of oxidative stress induced by CdCl2 on the thyroid gland of albino rats. In this study, rats were divided into 5 groups (n=5). Group 1 rats kept as control. Group 2 rats administered a single oral dose of 50mg/kg body weight of CdCl2 on day 1 and left for 30 days. Group 3 rats were given an oral dose of 150mg/kg body weight of curcumin daily for 30 days and kept as a positive control. Group 4 rats, acted as a post-treated group, administered a single oral dose of 50mg/kg body weight of CdCl2 on day 1 and 150mg/ kg body weight of curcumin daily for the next 30 days. Group 5 rats, acted as a pre-treated group, were given an oral dose of 150mg/kg body weight of curcumin daily for 30 days and 50 mg/kg body weight of CdCl2 on last day. In rats, acute CdCl2 treatment caused increased oxidative stress, decreased SOD, CAT and irregularities in normal levels of serum hormones (T3, T4, and TSH). In curcumin supplemented rats, level of Cd-induced lipid peroxidation was significantly lowered, the activity of SOD and CAT were significantly increased and improved serum hormone levels were noticed, which shows that curcumin to some degree could alleviate the toxic effects of CdCl2.

Key-Words / Index Term :
Cadmium, Curcumin, Thyroid, T3, T4, TSH, Oxidative Stress

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