Association of AVPR1A gene microsatellites with Autism Spectrum Disorder in south Indian population

D.Mandamkulathil ¹ , AA.Pillai ² , SA.Poovathinal ³ , SK.Chengappa ⁴ , A.Chandrasekar ⁵ , ASN Murthy⁶ , D.Srividhy Et⁷

Section:Research Paper, Product Type: Isroset-Journal
Vol.6 , Issue.1 , pp.203-207, Feb-2019

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v6i1.203207

Online published on Feb 28, 2019

Copyright © D.Mandamkulathil, AA.Pillai, SA.Poovathinal, SK.Chengappa, A.Chandrasekar, ASN Murthy, D.Srividhy Et . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Pharmacological studies have shown the therapeutic potential of Arginine Vasopressin Receptor (AVPR1A) for Autism Spectrum Disorders (ASDs) with socialization and communication symptoms. Present study investigated the association of promoter microsatellites (RS1 and RS3) polymorphisms of AVPR1A gene with ASDs in south Indian ethnicity. We recruited 225 subjects that constitutes of 118 ASD subjects diagnosed based on DSM-IV criteria and 107 controls, aged between 2 and 25 years of south Indian ethnicity. Case control association with RS1 allele length- 318bp, (P = 0.009); allele length- 330bp (P = 0.02); overall association with RS1 (P = 0.02) and RS3 allele length- 333bp (P = 0.002) , 335bp (P = 0.045) over all association (P = 0.002) with ASDs was found to be significant. Our results reveal that, RS1 and RS3 microsatellites of AVPR1A gene contribute to the susceptibility of ASD in south Indian ethnicity.

Key-Words / Index Term :
Autism Spectrum Disorder (ASD), AVPR1A, Allele, Microsatellites

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