Molecular docking studies of BCL- 2 with Erythroxylum monogynum Roxb. compounds for anti inflammatory studies

C. Dhanunjaya Kumar¹ , S. Nasireen Begum² , D. Muralidhara Rao³

Section:Research Paper, Product Type: Isroset-Journal
Vol.6 , Issue.3 , pp.73-80, Jun-2019

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v6i3.7380

Online published on Jun 30, 2019

Copyright © C. Dhanunjaya Kumar, S. Nasireen Begum, D. Muralidhara Rao . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Due to the presence of large number of phyto compounds the medicinal plants shows wide spread properties for diseases which are not cured by traditional medicine. In this work bioactive compounds of Erythroxylum monogynum plant extracts were selected .By the studies of Gas chromatography and mass spectrum the compounds present in Erythroxylum monogynum ethanolic extracts were identified based on retention time ,area. The compounds which were identified are used for anti inflammatory activity by insilico method with BCL-2 which plays key role in causing of inflammation. Hence this is selected for docking studies with the different compounds of Erythroxylum monogynum .The docking results showed that among compounds of Erythroxylum monogynum compounds the Cyclo Hexane, 2-Ethoxy -1-hydroxy-4-oxo-3-phntyl-32cyclobutenyl)acetate, 1,8-bis[(benzoyl)benzoyloxy]-3, 6-dioxa -octane,N-(Tetramethylpiperidinyl) ortho-fomyl benzoate , 1,30-Triacontanediol ,5-trichloro methyl-3-[1-(cyanothio)ethyl]-4, 5-dihydroisoxazol-5-ol.

Key-Words / Index Term :
Erythroxylum monogynum , Anti-inflammatory, Phyto compounds, BCL-2, Docking studies

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