Cell-Cell Coupling And Cell Hubness Make a Cell More Resistant Against Low-Frequency Electromagnetic Stress: A Computational Modeling Study

Sajjad Farashi¹

Section:Research Paper, Product Type: Journal-Paper
Vol.8 , Issue.1 , pp.36-40, Feb-2021

Online published on Feb 28, 2021

Copyright © Sajjad Farashi . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
In this study, a computational framework was used to check out how cell physical connections to neighboring cells and the hubness property of a cell affect its response to environmental stress such as extremely low-frequency electromagnetic (ELF-EMF) intervention. For this purpose, a mathematical model of a special kind of excitable cells, i.e. human pancreatic beta-cell was incorporated. The connection between cell models was also formulated by a mathematical expression. Furthermore, by changing the characteristics of the model toward increasing calcium dynamics, the hubness property was assigned to the cell model. Using this mathematical model the effect of ELF-EMF was investigated. The simulation results indicated that the physical connection of a cell to its neighbor cells enhanced its potential to tolerate ELF-EMF stresses, possibly via channel sharing or via perturbing ELF-EMF field. Also, when a cell possessed the hubness property, it showed higher resistance against ELF-EMF interventions, possibly due to different calcium dynamics compared with non-hub cells.

Key-Words / Index Term :
Computational modeling, Electromagnetic, Cell coupling, Hub-cell

References :
[1] M. Cifra, J. Z. Fields, and A. Farhadi, "Electromagnetic cellular interactions," Prog Biophys Mol Biol, vol. 105, pp. 223-46, May 2011.
[2] D. J. Panagopoulos, N. Messini, A. Karabarbounis, A. L. Philippetis, and L. H. Margaritis, "A mechanism for action of oscillating electric fields on cells," Biochemical and biophysical research communications, vol. 272, pp. 634-640, 2000.
[3] C. Wang, H. Zhang, D. Ren, Q. Li, S. Zhang, and T. Feng, "Effect of direct-current electric field on enzymatic activity and the concentration of laccase," Indian journal of microbiology, vol. 55, pp. 278-284, 2015.
[4] F. I. Wolf, A. Torsello, B. Tedesco, S. Fasanella, A. Boninsegna, M. D`Ascenzo, et al., "50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: possible involvement of a redox mechanism," Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, vol. 1743, pp. 120-129, 2005.
[5] Q. Jiao, X. Li, J. An, Z. Zhang, X. Chen, J. Tan, et al., "Cell-cell connection enhances proliferation and neuronal differentiation of rat embryonic neural stem/progenitor cells," Frontiers in cellular neuroscience, vol. 11, p. 200, 2017.
[6] S. Gurunathan, M.-H. Kang, M. Jeyaraj, M. Qasim, and J.-H. Kim, "Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes," Cells, vol. 8, p. 307, 2019.
[7] N. Tribulova, T. Egan Benova, B. Szeiffova Bacova, C. Viczenczova, and M. Barancik, "New aspects of pathogenesis of atrial fibrillation: remodelling of intercalated discs," J Physiol Pharmacol, vol. 66, pp. 625-34, 2015.
[8] A. Sherman and J. Rinzel, "Model for synchronization of pancreatic beta-cells by gap junction coupling," Biophys J, vol. 59, pp. 547-59, Mar 1991.
[9] J. Aguirre, E. Mosekilde, and M. A. Sanjuan, "Analysis of the noise-induced bursting-spiking transition in a pancreatic beta-cell model," Phys Rev E Stat Nonlin Soft Matter Phys, vol. 69, p. 041910, Apr 2004.
[10] M. Riz, M. Braun, and M. G. Pedersen, "Mathematical Modeling of Heterogeneous Electrophysiological Responses in Human beta Cells," Plos Comput Biol, vol. 10, p. e1003389, 2014
[11] S. Farashi, P. Sasanpour, and H. Rafii-Tabar, "The role of the transient receptor potential melastatin5 (TRPM5) channels in the pancreatic ?-cell electrical activity: A computational modeling study," Computational biology and chemistry, vol. 76, pp. 101-108, 2018.
[12] S. Farashi, P. Sasanpour, and H. R. Tabar, "Investigation the role of ion channels in human pancreatic ?-cell hubs: A mathematical modeling study," Comput Biol Med, vol. 97, pp. 50-62, 2018.
[13] N. R. Johnston, R. K. Mitchell, E. Haythorne, M. P. Pessoa, F. Semplici, J. Ferrer, et al., "Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose," Cell Metab, vol. 24, pp. 389-401, Sep 13 2016.
[14] J. Li, S. Liu, W. Liu, Y. Yu, and Y. Wu, "Suppression of firing activities in neuron and neurons of network induced by electromagnetic radiation," Nonlinear Dynamics, vol. 83, pp. 801-810, 2016.
[15] J. A. Robertson, J. Théberge, J. Weller, D. J. Drost, F. S. Prato, and A. W. Thomas, "Low-frequency pulsed electromagnetic field exposure can alter neuroprocessing in humans," Journal of the Royal Society Interface, vol. 7, pp. 467-473, 2010.
[16] S. Farashi, P. Sasanpour, and H. Rafii-Tabar, "Interaction of Low Frequency External Electric Fields and Pancreatic ?-Cell: A Mathematical Modeling Approach to Identify the Influence of Excitation Parameters," Int J Radiat Biol, 2018.
[17] P. Brink, "Gap junction voltage dependence: A clear picture emerges," The Journal of general physiology, vol. 116, pp. 11-12, 2000.
[18] T. A. Bargiello, Q. Tang, S. Oh, and T. Kwon, "Voltage-dependent conformational changes in connexin channels," Biochimica et Biophysica Acta (BBA)-Biomembranes, vol. 1818, pp. 1807-1822, 2012.
[19] P. Rorsman and F. M. Ashcroft, "Pancreatic ?-Cell Electrical Activity and Insulin Secretion: Of Mice and Men," Physiological reviews, vol. 98, pp. 117-214, 2018.
[20] M. G. Pedersen, "Contributions of Mathematical Modeling of Beta Cells to the Understanding of Beta-Cell Oscillations and Insulin Secretion," Journal of Diabetes Science and Technology, vol. 3, pp. 12-20, 2009/01/01 2009.
[21] A. Sherman, J. RiNZEL, and J. Keizer, "Emergence of organized bursting in clusters of pancreatic beta-cells by channel sharing," Biophysical journal, vol. 54, pp. 411-425, 1988.
[22] M. L. Pall, "Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects," Journal of cellular and molecular medicine, vol. 17, pp. 958-965, 2013.
[23] A. A. Pilla, "Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems," Biochemical and biophysical research communications, vol. 426, pp. 330-333, 2012.