Modified Biginelli Reaction Catalyzed by Cobaltous Chloride Conducted in Microwave

Reeta Singh¹

Section:Research Paper, Product Type: Isroset-Journal
Vol.3 , Issue.2 , pp.1-7, May-2016

Online published on May 21, 2016

Copyright © Reeta Singh . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
3, 4- Dihydropyrimidine -2(1H)-Ones were synthesized efficiently using CoCl2.6H2O as catalyst. The reaction was conducted by microwave irradiation without using any solvent. The prevased derivatives are expected antiviral, antitumor, antibacterial and anti-inflammatory action and used in treatment of cardiovascular diseases. These are remarkable pharmacological efficiency and calcium channel blockers.

Key-Words / Index Term :
Microwave, CoCl2 6H2O, Mlticomponent reaction, Biginelli Reaction, Calcium channel blockers, dihydropyrimidinone

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