Traditional Uses, Chemical Composition and Pharmacological Activities of The Genus Terminalia

Ruba Joujeh¹ , Dima Joujeh²

Section:Review Paper, Product Type: Journal-Paper
Vol.10 , Issue.4 , pp.19-31, Aug-2023

Online published on Aug 31, 2023

Copyright © Ruba Joujeh, Dima Joujeh . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Since ancient times, people have used medicinal plants to eliminate human diseases. Terminalia is the second largest genus of the Combretaceae family, with 200 species. It is an important genus, all the members of this genus are used in the treatment of many diseases. Terminalia species contain various secondary metabolites, such as flavonoids, chalcones, tannins, terpenoids, anthocyanidins, lignan, sterols. Due to the widespread and extensive medicinal uses of Terminalia species in folk medicine, their pharmacological effects have been the focus of many studies. The present review was undertaken to highlight the importance of this genus and summarizes the traditional uses, chemical composition and biological effects of some Terminalia species.

Key-Words / Index Term :
Terminalia, pharmacological activities, Combretaceae, Medicinal plants

References :
[1] S Khan, F Noor, I Sohail, S Imtiaz, F Anum, S Sarmad, S Kabir, S Raza. “Hepatoprotective role of fruit extract of Terminalia arjuna in acetaminophen intoxicated mice”. Adv. Life Sci.; Vol. 8, issue. 1, pp. 63- 67, 2020.
[2] A Amalraj, S Gopi. “Medicinal properties of Terminalia arjuna (Roxb.) Wight & Arn.: A review”. J Tradit Complement Med. Vol. 7, pp. 65–78, 2017. doi: dx.doi.org/10.1016/j.jtcme.2016.02.003.
[3] AA Khalaf, MK Galal, MA Ibrahim, AA Abd Allah, MM Afify, R Refaat. “The Terminalia laxiflora modulates the neurotoxicity induced by fipronil in male albino rats”. Biosci Rep. Vol. 39, pp. 1–10, 2019. doi: doi.org/10.1042/BSR20181363.
[4] AM Chahad, SA Adey, A Chatté, Z Louis, M Dijoux-Franca. “Chemical analysis and Biological properties of Terminalia macroptera Guill. & Perr. from Eastern Chad”. Mediterr J Chem. Vol. 11, issue. 1, pp. 104–114, 2021. doi: dx.doi.org/10.13171/mjc02102121561saa.
[5] XR Zhang, JS Kaunda, H Zhu, D Wang, C Yang, Y Zhang. “The Genus Terminalia (Combretaceae): An Ethnopharmacological, Phytochemical and Pharmacological Review”, Natural Products and Bioprospecting. Vol. 9 pp. 357-392, 2019. doi: doi.org/10.1007/s13659-019-00222-3.
[6] SS Mety, P Mathad. “Antioxidative and free radical scavenging activities of terminalia species”. Int Res J Biotechnol. Vol. 2, issue. 5, pp. 119–127, 2015.
[7] MJY Zai, MJ Cheesman, IE Cock. “The Interactive Antimicrobial Activities of Selected South African Terminalia spp. Extracts in Combination with Conventional Antibiotics against Gastrointestinal Pathogens”. Pharmacogn J. Vol. 14, issue. 6, pp. 692-701, 2022. doi: 10.5530/pj.2022.14.156.
[8] S Chakradhari, KP Rajhans, KS Patel, EK Towett, J Martín-gil, P Martín-ramos. “Nutritional and Spectral Characteristics of Terminalia Plants”. European J Med Plants. Vol. 27, issue. 4, pp. 1–13, 2019. doi: 10.9734/EJMP/2019/v27i430120.
[9] ZH Mbwambo, P Erasto, R Nondo, E Innocent, AW Kidukuli. “Antibacterial and cytotoxic activities of Terminalia stenostachya and Terminalia spinosa”. Tanzania J of Health Res. Vol. 13, issue. 2, pp. 1–8, 2011.
[10] M Rahman, R Habib, SMR Hasan, M Sayeed, S Rana. “Antibacterial, Cytotoxic and Antioxidant Potential of Methanolic Extract of Phyllanthus Acidus L.”. Int J Drug Dev Res. Vol. 3, issue. 2, pp. 154–161, 2011.
[11] S Thaakur, Ch Mangadevi, “Neuroprotective effect of alcoholic extract of Terminalia arjuna bark in experimental stroke induced rats”, Recent Researches in Modern Medicine, pp. 281-301, 2011.
[12] A Arya, S Nyamathulla, M Noordin, M Mohd. “Antioxidant and Hypoglycemic Activities of Leaf Extracts of Three Popular Terminalia Species”. E-Journal Chem., Vol. 9, issue. 2, pp. 883–892, 2012.
[13] D Raju, K Ilango, V Chitra, K Ashish. “Evaluation of Anti-ulcer activity of methanolic extract of Terminalia chebula fruits in experimental rats”. J Pharm Sci Res. Vol. 1, issue. 3, pp. 101–107, 2009.
[14] K Lin, M Zhou, C Leng, X Tao, R Zhou, Y Li, et al. “Neuroprotective Effect of Polyphenol Extracts from Terminalia chebula Retz. against Cerebral Ischemia-Reperfusion Injury”. molecules. Vol. 27, issue. 6449, pp. 1–15, 2022. doi: doi.org/10.3390/molecules27196449.
[15] GM Chaudhari, RT Mahajan. “In Vitro Hepatoprotective Activity of Terminalia arjuna Stem Bark and Its Flavonoids Against CCl4 Induced Hepatotoxicity in Goat Liver Slice Culture”. Asian J Plant Sci Res. Vol. 6, issue. 6, pp. 10–17, 2016.
[16] SM Ikikii, JO Odalo, AO Omondi, JM Kahindo. “Phytochemical screening and antimicrobial activity of flowers of Terminalia brownii”. J Pharmacogn Phytochem. Vol. 11, issue. 5, pp. 24–27, 2022. doi: doi.org/10.22271/phyto.2022.v11.i5a.14499.
[17] A Phama, K Malteruda, B Paulsena, D Diallob, H Wangensteen. “DPPH Radical Scavenging and Xanthine Oxidase Inhibitory Activity of Terminalia macroptera Leaves”. Nat Prod Commun. Vol. 6, issue. 8, pp. 1125–1128, 2011.
[18] A Khan, AH Gilani. “Pharmacodynamic Evaluation of Terminalia bellerica for Its Antihypertensive Effect”. J Food Drug Anal. 2008; Vol. 16, issue. 3, pp. 6–14.
[19] K Pinmai, W Hiriote, Soonthornchareonnon N, Jongsakul K. Sireeratawong S, Tor-Udom S. “In Vitro and In Vivo Antiplasmodial Activity and Cytotoxicity of Water Extracts of Phyllanthus emblica, Terminalia chebula, and Terminalia bellerica”. J Med Assoc Thai. Vol. 93, pp. S120–126, 2010.
[20] S Acharyya, A Si, P Bhuniya. “Evaluation of antimicrobial and anthelmintic activity of roots of Terminalia paniculata”. Pharma Innov J. Vol. 8, issue. 6, pp. 1065–1068, 2019.
[21] T Padumanonda, K Phontree. “Total Phenolic, Total Flavonoid, Total Condensed Tannin Contents and Antimicrobial Activity Against Diarrheal Bacteria of the Bark and Fruit of Terminalia nigrovenulosa Pierre ex Laness”. Sci Technol Asia. Vol. 26, issue. 1, pp. 162–9, 2021. doi: 10.14456/scitechasia.2021.14.
[22] A Ogunmoye, O Olubomehin, C Atewolara-Odule, S Ogundare, S Yussuf. “GC-MS Analysis of the Volatile Constituents from The Air-Dried Leaves of Terminalia catappa (Linnaeus)”. FUW Trends Sci Technol J. Vol. 5, issue. 3, pp. 948–951, 2020.
[23] MS Owolabi, OA Lawal, IA Ogunwande, R Setzer. “Chemical composition of the leaf essential pil of Terminalia catappa L. growing in southwestern Nigeria”. Am J Essent Oils Nat Prod. Vol. 1, issue. 1, pp. 51–54, 2013.
[24] A Hajdari, B Mustafa, D Nebija, A Kashtanjeva, J Widelski, K Glowniak, J Novak, “Essential oil composition and variability of Hypericum perforatum L. from wild population in Kosovo”, Current Issues in Pharmacy and Medical Sciences, Vol. 27, issue. 1, pp. 51–54, 2014. doi: 10.2478/cipms-2014-0013.
[25] I Jerkovi?a, M Marasovi?a, Z Marijanovi?b, K Pilepi?c, Ž Malešc, M Miloša, “Chemical Composition of Hypericum richeri subsp. grisebachii Essential Oil from Croatia”, Natural Product Communications, Vol. 8, issue. 2, pp. 231–233, 2013. doi:10.1177/1934578X1300800226.
[26] OM Owoade, Oke DG. “Chemical Composition of the Essential Oils from the Leaf, Stem-Bark and Twig of Terminalia mantaly H. Perrier (Combretaceae) from Nigeria”. Eur J Adv Chem Res. Vol. 1, issue. 5, pp. 1–4, 2020. DOI :10.24018/ejchem.2020.1.5.15.
[27] Ogunwande I, Ascrizzi R, Guido F. J. “Essential oil composition of Terminalia ivorensis A. Chev. flowers from Northern Nigeria”. Trends Phytochem Res. Vol. 3, issue. 1, pp. 77–82, 2019.
[28] Naik DG, Puntambekar H, Anantpure P. “Essential Oil of Terminalia chebula Fruits as a Repellent for the Indian Honeybee Apis florea”. Chem Biodivers. Vol. 7, pp. 1303–1310, 2010.
[29] Moronkola D, Ekundayo O. Chemical constituents in the fruit essential oil of Terminalia catappa Linn (almond fruits) ”. 2000.
[30] Bano S, Intisar A, Rauf M, Ghaffar A, Yasmeen F, Zaman W, et al. “Comparative analysis of oil composition and antibacterial activity of aerial parts of Terminalia arjuna (Roxb.)”. Natural Product Research, Vol. 34, issue. 9, pp. 1311-1314, 2020. doi.org/10.1080/14786419.2018.1557656.
[31] A Gurib-Fakim, F Demarne. “Essential Oil of Terminalia bentzoë (L.) L. f. subsp. rodriguesensis Wickens”. Journal of Essential Oil Research, Vol. 5, issue. 6, 1994. doi.org/10.1080/10412905.1994.9698443.
[32] S Kaur, “Phytopharmacological Activities of Terminalia Species, Pharmatutor, 2012.
[33] AA Mabrouk, S khalik, MIS Abdelhady, KF Taha, GTM Dawoud. Phytochemical Composition and Antioxidant Activity of Terminalia muelleri and Terminalia myriocarpa”. Egypt J Chem. Vol. 65, issue. 10, pp. 689–699, 2022.
[34] D Nguyen, D Seo, V Nguyen, K Kim, R Park, W Jung. “Nematicidal activity of gallic acid purified from Terminalia nigrovenulosa bark against the root-knot nematode Meloidogyne incognita”. Nematology. Vol. 15, issue. 5, pp. 507-518, 2013.
[35] M Tchuenmogne, T Kammalac, S Gohlke, R Kouipou. “Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significanc”. medicines. Vol. 4, issue. 6, pp. 1–12, 2017. doi:10.3390/medicines4010006.
[36] MN Shuaibu, PTA Wuyep, T Yanagi, K Hirayama, A Ichinose, T Tanaka, I Kouno. “Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides”, Parasitol Res, Vol. 102, pp. 697–703, 2008. DOI 10.1007/s00436-007-0815-1.
[37] Bushra, K Rehman, D Khan, AA Almehizia, AM Naglah, AS Al-wasidi, MS Refat, et al. “Isolation and Bioassay of a New Terminalone A from Terminalia arjuna”. molecules. Vol. 28, issue. 1015, pp. 1–10, 2023. doi.org/10.3390/molecules28031015.
[38] F Garcez, W Garcez, A Santana, M Alves, M Matos, “A Scaliante. Bioactive flavonoids and triterpenes from Terminalia fagifolia (Combretaceae) ”. J. Braz. Chem. Soc. Vol. 17, issue. 7, pp. 1223-1228, 2006. doi.org/10.1590/S010350532006000700005.
[39] WA El-kashak, SM Osman, AH Gaara, SA El-toumy, TK Mohamed, I Brouard, et al. “Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract”. Pharm Biol, Vol. 55, issue. 1, pp. 2277–2284, 2017. doi.org/10.1080/13880209.2017.1406531.
[40] W Oleszek, A Marston. “Saponins in Food, Feedstuffs and Medicinal Plants”, pp. 107-111, 2000.
[41] F Garcez, W Garcez, D Miguel, A Serea, F Prado. “Chemical constituents from Terminalia glabrescens”, J. Braz. Chem. Soc., Vol. 14, issue. 3, pp. 461-465, 2003. DOI:10.1590/S0103-50532003000300021.
[42] I Eldeen, E Elgorashi, D Mulholland, J Staden. “Anolignan B: A bioactive compound from the roots of Terminalia sericea”. Journal of Ethnopharmacology, Vol. 103, issue. 1, pp. 135-138, 2006. DOI:10.1016/j.jep.2005.09.005.
[43] M Yang, Z Alia, I Khana, S Khan. “Anti-inflammatory Activity of Constituents Isolated from Terminalia chebula”, Natural Product Communications, Vol. 9, issue. 7, pp. 965-968, 2014.
[44] F Mininel, C Junior, L Espanha, F Resende, E Varanda, C Leite. “Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity”, Evidence-Based Complementary and Alternative Medicine, issue. 676902, pp. 1-11, 2014. dx.doi.org/10.1155/2014/676902.
[45] A Rahman, S Zareen, M Choudhary, M Akhtar, S Shujaat, F Ngounou. “Some Chemical Constituents of Terminalia glaucescens and their Enzymes Inhibition Activity”, Verlag der Zeitschrift f¨ur Naturforschung. issue. 60b, pp. 347-350, 2005.
[46] S Opiyo, L Manguro, P Owuor, C Ochieng, E Ateka, P Lemmen. “Antimicrobial Compounds from Terminalia brownii against Sweet Potato Pathogens”, The Natural Products Journal, Vol. 1, issue. 2, pp. 116- 120, 2011. DOI: 10.2174/2210315511101020116.
[47] T Patnaik, RK Dey, P Gouda. “Isolation of Triterpenoid Glycoside from Bark of Terminalia arjuna using Chromatographic Technique and Investigation of Pharmacological Behavior upon Muscle Tissues”, Journal of Chemistry, Vol. 4, issue. 4, pp. 474-479, 2007. https://doi.org/10.1155/2007/538932.
[48] D Pertuit, A Mitaine-Offer, T Miyamoto, C Tanaka, S Delemasure, P Dutartre, M Lacaille-Dubois, “A New Aromatic Compound from the Stem Bark of Terminalia catappa”, Nat Prod Commun. Vol. 10, issue. 6, pp. 1005-1007, 2015. doi.org/10.1177/1934578X1501000652.
[49] AB Joshi, M Aswathi, M Bhobe. “Terminalia tomentosa Roxb (ex DC) Wight & Arn: Phytochemical Investigatio”. Am J Adv Drug Deliv. Vol. 3, issue. 1, pp. 224–231, 2013.
[50] B Chafamo, L Adane, F Mamo. “Phytochemical investigation of the roots extracts of Terminalia brownie and isolation of dimethyl terephthalate”. J Pharmacogn Phytochem. Vol. 7, issue. 2, pp. 664–670, 2018.
[51] M Khan, L Bala, M Maliki. “Phytochemical Analyses of Terminalia schimperiana (Combretaceae) Root Bark Extract to Isolate Stigmasterol”. Adv J Chem A. Vol. 2, issue. 4, pp. 327–334, 2019. DOI: 10.33945/SAMI/AJCA.2019.4.6.
[52] JS Bulama, SM Dangoggo, SN Mathias, “Isolation and Characterization of Beta-Sitosterol from ethyl acetate extract of root bark of Terminalia glaucescens”, International Journal of Scientific and Research Publications, Vol. 5, issue. 3, pp. 1-3, 2015.
[53] C Chinaka, K Ezealisiji, R Akpofure. “Phyto-chemical Characterization of the Leaf extracts of Terminalia catappa L. (Combretaceae) Using Ultra violet-Visible, Fourier transform infrared and Gas chromatography-Mass Spectroscopic techniques”. J Pharmacogn Phytochem. Vol. 7, issue. 1, pp. 2017–2023, 2018.
[54] H Biruk, B Sentayehu, Y Alebachew, W Tamiru, A Ejigu, S Assefa. “In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice”. Biochem Res Int. pp. 1–7, 2020. doi: doi.org/10.1155/2020/9749410.
[55] B Samuel, YA Adekunle. “Isolation and structure elucidation of anti-malarial principles from Terminalia mantaly H. Perrier stem bark”. Int J Biol Chem Sci. Vol. 15, issue. 1, pp. 282–292, 2021. doi: https://dx.doi.org/10.4314/ijbcs.v15i1.25.
[56] M Haidara, M Haddad, A Denou, G Marti, S Bourgeade-delmas, R Sanogo, et al. “In vivo validation of anti-malarial activity of crude extracts of Terminalia macroptera, a Malian medicinal plant”. Malar J. Vol. 17, issue. 68, pp. 1–10, 2018. doi: doi.org/10.1186/s12936-018-2223-7.
[57] CD Mbouna, RMT Kouipou, R Keumoe, LRY Tchokouaha, PVT Fokou, BMT Tali, et al. “Potent antiplasmodial extracts and fractions from Terminalia mantaly and Terminalia superba”. Malar J. Vol. 17, issue. 142, pp. 1–10, 2018. doi: doi.org/10.1186/s12936-018-2298-1.
[58] F Machumia, J Midiwob, M Jacoba, S Khana, B Tekwania, J Zhang, LA Walker. “Phytochemical, Antimicrobial and Antiplasmodial Investigations of Terminalia brownii”. Nat Prod Commun. Vol. 8, issue. 6, pp. 761–764, 2013. doi: doi.org/10.1177/1934578X1300800619.
[59] R Valsaraj , P Pushpangadan, UW Smitt, A Adsersen, SB Christensen, A Sittie, U Nyman, C Nielsen, C Olsen. “New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica”, J Nat Prod, Vol. 60, issue. 7, pp. 739-742, 1997. doi: 10.1021/np970010m.
[60] AO Matthew, E Olusola, O Ademola, A Aderotimi, J Adebola. “Anti-malarial Activity of Total Saponins from Terminalia avicennioides and Its Effect on Liver and Haematological of Infected Mice”, Drug Des, Vol. 7, issue. 2, 2018. DOI: 10.4172/2169-0138.1000161.
[61] A Camara, M Haddad, K Reybier, MS Traoré, MA Baldé, J Royo, et al. “Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti inflammatory properties”. Malar J. Vol. 18, issue. 431, pp. 1–15, 2019. doi: doi.org/10.1186/s1293 6-019-3071-9.
[62] A Bagavan, AA Rahuman, C Kamaraj, N Kaushik, D Mohanakrishnan, D Sahal. “Antiplasmodial activity of botanical extracts against Plasmodium falciparum”. Parasitol Res. Vol. 108, pp. 1099–1109, 2011. doi:10.1007/s00436-010-2151-0.
[63] E Hnawia, L Hassani, E Deharo, S Maurel, J Waikedre, P Cabalion, et al. “Antiplasmodial activity of New Caledonia and Vanuatu traditional medicines”. Pharm Biol. Vol. 49, issue. 4, pp. 369–76, 2011. doi: 10.3109/13880209.2010.517541.
[64] M Tali, C Mbouna, L Tchokouaha, P Fokou, et al., “In Vivo Antiplasmodial Activity of Terminalia mantaly Stem Bark Aqueous Extract in Mice Infected by Plasmodium berghei”. J Parasitol Res. pp. 1–9, 2020. doi: doi.org/10.1155/2020/4580526.
[65] R Muganga, L Angenot, M Tits, M Frédérich. “In Vitro and In Vivo Antiplasmodial Activity of Three Rwandan Medicinal Plants and Identification of Their Active Compounds”. Planta Med. Vol. 80, pp. 482–489, 2014. doi: dx.doi.org/ 10.1055/s-0034-1368322.
[66] S Sanon, A Gansane, LP Ouattara, A Traore, IN Ouedraogo, et al. “In vitro antiplasmodial and cytotoxic properties of some medicinal plants from western Burkina Faso”. Afr J Lab Med. Vol. 2, issue. 1, pp. 1–7, 2013. doi:10.4102/ajlm.v2i1.81.
[67] L Ouattara, S Sanon, V Mahiou-Leddet, A Gansané, B Baghdikian, A Traoré, I Nébié, A Traoré, N Azas, E Ollivier, S Sirima. “In vitro antiplasmodial activity of some medicinal plants of Burkina Faso, Parasitology Research, Vol. 113, pp. 405–416, 2014.
[68] EB Berinyuy, M Abdullahi, AY Kabiru, EO Ogbadoyi. “Comparative Anti-malarial and Toxicological Properties of the Stem Bark Extracts of Nauclea latifolia and Terminalia glaucescens Against Plasmodium berghei-infected mice”. Iranian Journal of Toxicology. Vol. 14, issue. 1, pp. 9-18, 2020. doi: dx.doi.org/10.32598/ijt.14.1.9
[69] G Bharath, K Divya, G Sravanthi, G Rajeshwar, V Umadevi, K Niranjan. “Antiulcer Activity of Ethanolic Extract of Terminalia catappa Leaves against Gastric Ulcers by Pyrolic Ligation Induced Model in Rats”. Int J Pharm Sci Drug Res. Vol. 6, issue. 1, pp. 38–40, 2014.
[70] MS Ali Khan, S Nazan, AM Mat Jais. “Flavonoids and anti-oxidant activity mediated gastroprotective action of Leathery Murdah, Terminalia coriacea (Roxb.) Wight & Arn. Leaf methanolic extract in rats”. Arq Gastroenterol. Vol. 54, pp. 183–191, 2017. doi: dx.doi.org/10.1590/S0004-2803.201700000-21.
[71] H Jawanjal, M Rajput, P Agrawal, V Dange. “Pharmacological Evaluation of Fruits of Terminalia belerica Roxb. for Antiulcer Activity”, Journal of Complementary and Integrative Medicine, Vol. 18, issue. 9, 2012. doi: doi.org/10.1515/1553-3840.1556.
[72] MM Suleiman, IO Romanus, S Yusuf. “Gastroprotective effect of the crude methanol extract of Terminalia avicennioides in rats”. Vet Arh. 2007; Vol. 77, issue. 4, pp. 345–354.
[73] RS Devi, M Kist, G Vani, C Devi. “Effect of methanolic extract of Terminalia arjuna against Helicobacter pylori 26695 lipopolysaccharide-induced gastric ulcer in rats”. J Pharm Pharmacol. Vol. 60, pp. 505–514, 2008. doi 10.1211/jpp.60.4.0014.
[74] M Menshawy, M El Raey, A Hamdy, A Farrag. “Anti-Ulcer Activity of Terminalia Laxiflora Engl. and Diels Leaves Extracts Against Aspirin Induced Gastric Ulcer in Rats”. Int J Adv Res. Vol. 5, issue. 7, pp. 2092–2100, 2017. doi: 10.21474/IJAR01/4946.
[75] Y Shena, C Juand, C Linf, C Chenf, C Chang. “Neuroprotective Effect of Terminalia Chebula Extracts and Ellagic Acid in PC12 Cells”. Afr J Tradit Complement Altern Med. Vol. 14, issue. 4, pp. 22–30, 2017. doi: doi.org/10.21010/ajtcam.v14i4.3.
[76] L Ior, S Otimenyin, J Gushit. “Neuroprotective effects of methanol extract of Terminalia macroptera leaf in mice”. African J Pharm Pharmacol. Vol. 14, issue. 8, pp. 300–307, 2020. doi: 10.5897/AJPP2020.5160.
[77] B Ben-Azu, A Aderibigbe, A Ajayi, E Iwalewa. “Neuroprotective effects of the ethanol stem bark extracts of Terminalia ivorensis in ketamine-induced schizophrenia-like behaviors and oxidative damage in mice”, Pharmaceutical Biology, Vol. 54, issue. 12, pp. 2871-2879, 2016. doi: doi.org/10.1080/13880209.2016.1190382.
[78] RV Suvarchala, RM Ganga, GM Rahul, T Shabnamkumari. “Neuroprotective Activity of Methanolic extract of Terminala bellerica Fruit against Aluminium Chloride and Haloperidol Induced Amnesia in Mice”. J Young Pharm. Vol. 12, issue. 2, pp. 87–90, 2020.
[79] R Vijaya, R Abinaya. “An Effect of Cardioprotective Activity in Various Medicinal Plants–A Review”. Int J Curr Pharm Res. Vol. 11, issue. 2, pp. 1–6, 2019.
[80] F Khaliq, M Fahim. “Role of Terminalia Arjuna in Improving Cardiovascular Functions: A Review”. Indian J Physiol Pharmacol. Vol. 62, issue. 1, pp. 8–19, 2018.
[81] S Bagalkote, S Hugar, A Javalgikar. “Evaluation of Cardioprotective Activity of Terminalia Catappa Leaves Against Doxorubicin Induced Myocardial Infarction in Albino Rats”. Int J Curr Med Pharm Res. Vol. 4, issue. 2, pp. 3045–3047, 2018.
[82] R Manikandan, B Balasubramanian, P Punniyakotti, A Anand, A Meyyazhagan, S Velayuthaprabhu. “Cardio-protective effects of terminalia catappa leaves and terminalia chebula fruit extract in doxorubicin-induced cardiomyopathy in rats”, Biomarkers, Vol. 27, pp. 1-21, 2022. doi: doi.org/10.1080/1354750X.2022.2064550.
[83] V Sivakumar, S Rajeshkumar. “Screening of cardioprotective effect of Terminalia arjuna Linn. bark in isoproterenol-Induced myocardial infarction in experimental animals”. Int J Pharma Sci Res. Vol. 5, issue. 6, pp. 262–268, 2014.
[84] A Shaik, N Rasool, A Reddy, A Kareem. “Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats”, Journal of Ethnopharmacology, Vol. 141, issue. 1, pp. 33-40, 2012. doi:10.1016/j.jep.2012.01.011.
[85] KR Aneja, C Sharma, R Joshi. “Antimicrobial activity of Terminalia arjuna Wight & Arn.: An ethnomedicinal plant against pathogens causing ear infection”. Braz J Otorhinolaryngol. Vol. 78, issue. 1, pp. 68–74, 2012.
[86] MPJ Dharmaratne, A Manoraj, V Thevanesam, A Ekanayake, NS Kumar, V Liyanapathirana, et al. “Terminalia bellirica fruit extracts: in-vitro antibacterial activity against selected multidrug-resistant bacteria, radical scavenging activity and cytotoxicity study on BHK-21 cells”. BMC Complement Altern Med. Vol. 18, issue. 325, pp. 1–12, 2018. doi: doi.org/10.1186/s12906-018-2382-7.
[87] H Babayi, I Kolo, J Okogun, U Ijah. “The antimicrobial activities of methanolic extracts of Eucalyptus camaldulensis and Terminalia catappa against some pathogenic microorganisms”. Biokemistri. Vol. 16, issue. 2, pp. 106–111, 2004.
[88] AA Rani, S Jeeva, SMJ Punitha, AA Rani. “Assessment of antimicrobial properties of Terminalia chebula (fruit) against cariogenic organisms”. Der Pharm Lett. Vol. 8, issue. 5, pp. 432–441, 2016.
[89] C Sharma, K Aneja, R Kasera, A Aneja. “Antimicrobial potential of Terminalia chebula Retz. fruit extracts against ear pathogens”. World J Otorhinolaryngol. Vol. 2, issue. 2, pp. 8–13, 2012. doi:10.5319/wjo.v2.i2.8.
[90] TV Dougnon, JR Klotoe, A Eugénie, YS Nadjo, B Fanou, et al. “Antibacterial and Wound Healing Properties of Terminalia superba Engl. and Diels (Combretaceae) in Albino Wistar Rats”. J Bacteriol Parasitol. Vol. 5, issue. 5, pp. 1-6, 2014. doi:10.4172/2155-9597.1000206.
[91] MC Glory, ME Kevin. “The Antimicrobial Properties of Terminalia Glaucescens and Zanthoxylum Zanthoxyloides Extracts and the Spectrum of their Activity”. South Am J Public Heal. Vol. 3, issue. 4, pp. 1–11, 2015.
[92] ST Asma, U Acaroz, K Imre, A Morar, S Shah, SZ Hussain, et al. “Natural Products/ Bioactive Compounds as a Source of Anticancer Drugs”. Cancers. Vol. 14, issue. 6203, pp. 1–23, 2022. doi: doi.org/10.3390/cancers14246203.
[93] H Aliyu-amoo, HI Isa, EM Njoya, LJ Mcgaw. “Antiproliferative effect of extracts and fractions of the root of Terminalia avicennioides (Combretaceae) Guill and Perr. on HepG2 and Vero cell lines”. Clin Phytoscience. Vol. 7, issue. 71, pp. 1–7, 2021. doi: doi.org/10.1186/s40816-021-00307-y.
[94] H Zarredar, A Khamaneh, F Amoodizaj, D Shanehbandi, E Seyedrezazadeh, HS Jadid, M Asadi, V Zafari, Y Khalili, Z Soleimani, A Ansarin, M Khalili. “Terminalia catappa Extract (TCE) Reduces Proliferation of Lung and Breast Cancer Cell by Modulating miR-21 and miR-34a Expressions”, Asian Pac J Cancer Prev, Vol. 22, issue. 4, pp. 1157-1163, 2021. doi:10.31557/APJCP.2021.22.4.1157.
[95] BE Shankara, YL Ramachandra, SS Rajan, PS Sujan Ganapathy, NS Yarla, SA Richard, et al. “Evaluating the anticancer potential of ethanolic gall extract of Terminalia chebula (Gaertn.) Retz. (combretaceae)”. Phcog Res. Vol. 8, issue. 3, pp. 209-212, 2016. doi: 10.4103/0974?8490.182919.
[96] A Heer, V Sharma, N Kour, S Sharma. “Terminalia chebula possesses in vitro anticancer potential”. Indian J Pharm Pharmacol. Vol. 9, issue. 4, pp. 242–246, 2022. doi: doi.org/10.18231/j.ijpp.2022.044.
[97] M Wang, L Yang, M Ji, P Zhao, P Sun, R Bai, et al. “Aqueous Extract of Terminalia chebula Induces Apoptosis in Lung Cancer Cells Via a Mechanism Involving Mitochondria-mediated Pathways”. Braz Arch Biol Technol. Vol. 58, pp. 208–215, 2015. doi: dx.doi.org/10.1590/S1516-8913201400202.
[98] B Sintayehu, B Kakoti, M Kataki, M Gebrelibanos. “Hepatoprotective, antixidant and anticancer activities of Terminalia brownii Fresen leaf extract”. Ethiop. Pharm. J. Vol. 33, pp. 29-38, 2017. doi: dx.doi.org/10.4314/epj.v33i1.3.
[99] K Rashed, N Esa, S Ismail. “Anti-cancer activity of three terminalia species and preliminary phytochemical screening”, Jordan Journal of Pharmaceutical Sciences, Vol. 9, issue. 3, pp. 175-180, 2016.
[100] B Gu, J Shalom, IE Cock, B Gu, J Shalom, IE Cock. “Anti-Proliferative Properties of Terminalia sericea Burch. Ex Dc Leaf Extracts Against Caco2 and HeLa Cancer Cell Lines”. Pharmacogn J. Vol. 10, issue. 3, pp. 408–415, 2018. doi: 10.5530/pj.2018.3.67.
[101] B Moulisha, GA Kumar, HP Kanti. “Anti-leishmanial and Anti-cancer Activities of a Pentacyclic Triterpenoid Isolated from the Leaves of Terminalia arjuna Combretaceae”. Trop J Pharm Res. Vol. 9, issue. 2, pp. 135–140, 2010.
[102] MF Akhtar, A Saleem, A Sharif, B Akhtar, MB Nasim, S Peerzada, et al. “Genotoxic and Cytotoxic Action Potential of Terminalia Citrina, A Medicinal Plant of Ethnopharmacological Significance”. Excli J. Vol. 15, pp. 589–598, 2016. doi: dx.doi.org/10.17179/excli2016-551.
[103] R Jain, K Nandakumar, V Srivastava, SK Vaidya, S Patet, P Kumar. “Hepatoprotective activity of ethanolic and aqueous extract of Terminalia belerica in rats”. Pharmacologyonline. Vol. 2, pp. 411–427, 2008.
[104] S Palani, S Raja, D Venkadesan, S Karthi, K Sakthivel, B Kumar. “Antioxidant activity and hepatoprotective potential of Terminalia pallida”. Arch Appl Sci Res. Vol. 1, issue. 1, pp. 18–28, 2009.
[105] BR Eesha, V Mohanbabu, K Meena, B Sarath, M Vijay, M Lalit, R Rajput. “Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats”. Asian Pac J Trop Med. pp. 466–469, 2011. doi: dx.doi.org/10.1016/S1995-7645(11)60127-2.
[106] M Choi, H Kim, J Han, J Lee, JS Lee, SH Chung, C Son. “Hepatoprotective Effect of Terminalia chebula against t -BHP-Induced Acute Liver Injury in C57/BL6 Mice”. Evidence-Based Complement Altern Med. pp. 1–11, 2015. doi: dx.doi.org/10.1155/2015/517350.
[107] A Abdul Vahab, J Harindran. “Hepatoprotective Activity of Bark Extracts of Terminalia Catappa Linn in Albino Rats”. World J Pharm Pharm Sci. Vol. 5, issue. 6, pp. 1002–1016, 2016.
[108] J Gao, X Tang, H Dou, Y Fan, X Zhao, Q Xu. “Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids”, J Pharm Pharmacol, Vol. 56, issue. 11, pp. 1449-1455, 2004. doi: 10.1211/0022357044733.
[109] AR Abdulkadir. “In Vitro Antioxidant Activity of Ethanolic Extract from Terminalia Catappa (L.) Leaves and Fruits: Effect of Fruit Ripening”. Int J Sci Res. Vol. 4, issue. 8, pp. 1244–1249, 2015.
[110] F Abo-Elghiet, A Abd-elsttar, A Metwaly, A Mohammad. “In-vitro comparative evaluation of antioxidant, anti-inflammatory, and antimicrobial potentialities of Terminalia arjuna leaves, fruits, and bark. Azhar Int J Pharm Med Sci. Vol. 2, issue. 2, pp. 148-158, 2022. doi: 10.21608/AIJPMS.2022.127469.1117.
[111] M Krishnaveni. “In vitro antioxidant activity of Terminalia catappa nuts”. Asian J Pharm Clin Res, Vol. 7, issue. 4, pp. 33–35, 2014.
[112] Y Zou, G Ho, K Malterud, N Le, K Inngjerdingen, H Barsett, et al. “Enzyme inhibition, antioxidant and immunomodulatory activities, and brine shrimp toxicity of extracts from the root bark, stem bark and leaves of Terminalia macroptera”, Journal of Ethnopharmacology, Vol. 155, issue. 2, pp. 1219-1226, 2014.
[113] J Vaghela, S Sisodia. “In Vitro Antioxidant Activity of Terminalia chebula Fruit Extracts”. Res J. Pharm. and Tech. Vol. 4, issue. 12, pp. 1835-1843, 2011.
[114] K Rakholiya, M Kaneria, K Nagani, A Patel, S Chanda. “Comparative Analysis and Simultaneous Quantification of Antioxidant Capacity of Four Terminalia Species Using Various Photometric Assays”. World J Pharm Res. Vol. 4, issue. 4, pp. 1280–296, 2015.
[115] J Yoda, S Sourabié, A Zoungrana. “Antioxidant Activity of Five Medicinal Plants Extrats Used for Management of Bacterial Diseases in Burkina Faso”. Adv Anal Chem. Vol. 10, issue. 2, pp. 20–25, 2020 doi: 10.5923/j.aac.20201002.02.
[116] S Akhter. I Hossain, A Haque, M Shahriar, M Bhuiyan. “Phytochemical Screening, Antibacterial, Antioxidant and Cytotoxic Activity of the Bark Extract of Terminalia Arjuna”. Eur J Sci Res. Vol. 86, issue. 4, pp. 543–552, 2012.
[117] OS Awotunde, SP Dhanabal, R Raman, M Chasitainya. “Antioxidant activities of Hydro-ethanol and Saponin extracts of Terminalia schimeperiana root”. Der Pharm Lett. Vol. 9, issue. 11, pp. 47–53, 2017.
[118] G Kumar, P Arulselvan, DS Kumar, SP Subramanian. “Anti-Diabetic Activity of Fruits of Terminalia chebula on Streptozotocin Induced Diabetic Rats”. J Heal Sci. Vol. 52, issue. 3, pp. 283–291, 2006.
[119] S Yahaya, M Suleiman, A Mohammed, N Ibrahim. “Anti-diabetic potentials of stem-bark extracts of Terminalia avicennioides on alloxan-induced diabetic rats”. Sokoto J Vet Sci. Vol. 17, issue. 2, pp. 33–44, 2019.
[120] B Ragavan, S Krishnakumari. “Antidiabetic Effect of T. Arjuna Bark Extract in Alloxan Induced Diabetic Rats”. Indian J Clin Biochem. Vol. 21, issue. 2, pp. 123–128, 2006.
[121] AN Nagappa, PA Thakurdesai, NV Raob, J Singh. “Antidiabetic activity of Terminalia catappa Linn fruits”, Journal of Ethnopharmacology, Vol. 88, pp. 45–50, 2003.
[122] FN Iheagwam, OT Iheagwam, MK Onuoha, OO Ogunlana, SN Chinedu. “Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/ streptozotocin induced diabetic rats”. Sci Rep. Vol. 12, issue. 10711, pp. 1–15, 2022. doi: doi.org/10.1038/s41598-022-15114-9.
[123] NM Alema, G Periasamy, G Sibhat, G Tekulu, M Hiben. “Antidiabetic Activity of Extracts of Terminalia brownii Fresen. Stem Bark in Mice”. J Exp Pharmacol. Vol. 12, pp. 61–71, 2020.
[124] V Kasabri, PR Flatt, YH Abdel-wahab. “Terminalia bellirica stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro”. Br J Nutr. Vol. 103, pp. 127-212, 2010. doi: 10.1017/S0007114509991577.