Genotoxic, Carcinogenic and Reproductive Studies on Aniline: A Mini Review

Ingle Vaibhavi¹ , Dhurvey Varsha² , Urkude Rashmi³

Section:Review Paper, Product Type: Journal-Paper
Vol.10 , Issue.4 , pp.42-47, Aug-2023

Online published on Aug 31, 2023

Copyright © Ingle Vaibhavi, Dhurvey Varsha, Urkude Rashmi . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
The presence of certain chemical pollutants in environment plays an important role in altering various biological functions. Anilines are widely used in the preparation of pesticides, herbicides, plants, pharmaceuticals and dyes. The present review aims at highlighting the toxic and detrimental effects of aniline on animal model. We believe that this review will provide valuable information on toxicological profile of aniline which will further help in devising safe guidelines for the usage of aniline in a suitable manner. Aniline has shown increases the methemoglobin level in blood. A derivative of aniline, 3,4 dichloroaniline, has shown to affect the male reproductive system by increasing the frequency of structural and numerical abnormalities in sperms, decreasing sperm count and motility. In female fishes, it, decreased fecundity, caused hormonal disruption and histological changes in the ovaries. In rats, aniline hydrochloride did not show any teratogenic effect but the pregnant rats showed increased spleen weight, decreased RBC count and methemoglobinemia.

Key-Words / Index Term :
Aniline, testes, ovaries, hormones, sperm count, reproductive output

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