The Role of Medicinal Plants in Protecting Mesenchymal Stromal Cells From Oxidative Stress

Ruba Joujeh¹ , Dima Joujeh²

Section:Research Paper, Product Type: Journal-Paper
Vol.10 , Issue.5 , pp.23-28, Oct-2023

Online published on Oct 31, 2023

Copyright © Ruba Joujeh, Dima Joujeh . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

View this paper at   Google Scholar | DPI Digital Library

XML View     PDF Download

How to Cite this Paper

Abstract :
Recently, research has focused on mesenchymal stromal cells (MSCs) as one of the most important therapeutic products, which have been effectively used in the treatment of many diseases. However, the functionality and longevity of in vitro expanded MSCs are greatly affected by oxidative stress. Moreover, most of the transplanted MSCs are lost in few days following transplantation, due to the hypoxia and the presence of oxygen-free radicals in the transplant recipient, that increase aging factors. Therefore, strategies that protect MSCs from apoptosis and increase their resistance to oxidative stress are required for optimizing MSC?based therapy. It has been shown recently that some plant compounds can protect MSC from oxidative stress. Therefore, the present review highlights the role of medicinal plants in modulating oxidative stress in MSC. We hope that this review will provide additional information that will facilitate and improve MSC-based therapies.

Key-Words / Index Term :
mesenchymal stem/stromal cells, oxidative stress, plant extracts, plant derived compounds, MSC apoptosis

References :
[1]. D Joujeh, A Ghrewaty, C Soukkarieh, A Almarrawi, J Darwicha. “An optimized protocol for mouse bone marrow mesenchymal stromal cells isolation and culture”. Cell Th er Transplant, Vol.10, Issue.3-4, pp.61-70, 2021. doi: 10.18620/ctt-1866-8836-2021-10-3-4-61-70.
[2]. B. Saud, R. Malla, and K. Shrestha, “A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation”, Stem Cells Int., Vol.2019, ID. 7513404, pp.1–13, 2019. Doi: doi.org/10.1155/2019/7513404.
[3]. J Lee, H Jung, Y Han, Y Yoon, C Yun, H Sun, H Cho and S Lee. “Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells,” Mol. Med. Rep., Vol.14, pp.3777–3784, 2016.
[4]. Q Jiang, X Li, Y Tian, Q Lin, H Xie, W Lu, Y Chi and D Chen. “Lyophilized aqueous extracts of Mori Fructus and Mori Ramulus protect Mesenchymal stem cells from • OH – treated damage: bioassay and antioxidant mechanism”, BMC Complement. Altern. Med., Vol.17, Issue.242, pp.1–11, 2017. Doi: 10.1186/s12906-017-1730-3.
[5]. 5. X Li, Y Gao, F Li, A Liang, Z Xu, Y Bai, W Mai, et al., “Maclurin protects against hydroxyl radical-induced damages to mesenchymal stem cells: Antioxidant evaluation and mechanistic insight”. Chemico-Biological Interactions, Vol.219, pp.221-228, 2014. Doi: doi.org/10.1016/j.cbi.2014.06.014.
[6]. S Dehghani, L Rouhi, N Ziya Jahromi, R Dehghani, Kh Khashei Varnamkhasti. “The Antioxidant Effects of Ginger Extract on Bioavailability and Oxidative Stress-induced Apoptosis in Mesenchymal Stem Cells of Human Adipose Tissue and Rat Bone Marrow”. Journal of Arak University of Medical Sciences. Vol.24, Issue.2, pp.216-229, 2021. Doi: doi.org/10.32598/ JAMS.24.2.6146.4.
[7]. D Huang, L Yin, X Liu, B Lv, Z Xie, X Wang, B Yu, and Y Zhang. “Geraniin protects bone marrow derived mesenchymal stem cells against hydrogen peroxide induced cellular oxidative stress in vitro,” Int. J. Mol. Med., Vol.41, pp.739–748, 2018. DOI: 10.3892/ijmm.2017.3276.
[8]. H Khawaja, N Fazal, F Yaqub, MR Ahmad, M Hanif, MA Yousaf, N Latief. “Protective and proliferative effect of Aesculus indica extract on stressed human adipose stem cells via downregulation of NF-?B pathway”. PLoS ONE, vol. 16, issue. 10, pp. 1-17, 2021. Doi: doi.org/10.1371/journal. pone.0258762.
[9]. E Monageng, U Offor, N Takalani, K Mohlala and C Opuwari, “A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells,” antioxidants, Vol.12, Issue.1559, pp.1-29, 2023. Doi: doi.org/10.3390/antiox12081559.
[10]. H Kumar, R Dhalaria, S Guleria, R Cimler, R Sharma, S Siddiqui, “Anti-oxidant potential of plants and probiotic spp. in alleviating oxidative stress induced by H2O2” Oxid. Med. Cell. Longev., ID 4586068, pp. 1–9, 2017. Doi: doi.org/10.1155/2017/4586068.
[11]. M Vallejo, L Salazar, and M Grijalva, “Oxidative Stress Modulation and ROS-Mediated Toxicity in Cancer: A Review on In Vitro Models for Plant-Derived Compounds,” Oxid. Med. Cell. Longev., ID 4586068, pp.1–9, 2017. Doi: doi.org/10.1155/2017/4586068.
[12]. N shakerinasab, M Bejeshk, H Pourghadamyari, H Najafipour, M Eftekhari, J Mottaghipisheh, N Omidifar, M Azizi, M Rajizadeh and A Doustimotlagh, “The Hydroalcoholic Extract of Nasturtium officinale Reduces Lung Inflammation and Oxidative Stress in an Ovalbumin- Induced Rat Model of Asthma,” Evidence-Based Complement. Altern. Med., ID. 5319237, pp.1–10, 2022. Doi: doi.org/10.1155/2022/5319237.
[13]. S Nazem, M Masoumi, N Amirizadeh, F Zolghadr, M Sadeghizadeh. “Protective Effect of Encapsulated Nanocurcumin- PEGOA against Oxidative Damage on Human Mesenchymal Stem Cells Exposed to Hydroquinone as a Risk Factor for Leukemia,” Multidiscip. Cancer Investig., Vol.1, Issue.1, pp.1–10, 2017. DOI: 10.21859/mci-01011.
[14]. A El-hady and N Aljalaud, “Therapeutic Effects of Olive Leaf Extract or Bone Marrow Mesenchymal Stem Cells against Lung Damage Induced In Male Albino Rats Exposed To Gamma Radiation,” Egypt. J. Hosp. Med., vol. 61, pp. 685–699, 2015. DOI: 10.12816/0018770.
[15]. N Fazal, H Khawajaa, N Naseera, A Khanb, and N Latief, “Daphne mucronata enhances cell proliferation and protects human adipose stem cells against monosodium iodoacetate induced oxidative stress in vitro,” Adipocyte, vol. 9, issue. 1, pp. 495–508, 2020. Doi: doi.org/10.1080/21623945.2020.1812242.
[16]. E Shaker1 and S Mnaa, “Protective Effect of Some Local Plants against Oxidative Stress Caused by Hydrogen Peroxide,” J. Environ. Toxicol. Stud., vol. 1.1, pp. 1–4, 2017. doi: dx.doi.org/10.16966/2576-6430.104.
[17]. P Kaur, G Kaur, M P Bansal, “Tertiary-butyl hydroperoxide induced oxidative stress and male reproductive activity in mice: Role of transcription factor NF-?B and testicular antioxidant enzymes”, Reproductive Toxicology, Vol. 22, Issue 3, pp. 479-484, 2006. Doi: doi.org/10.1016/j.reprotox.2006.03.017.
[18]. R Endlicher, T Roušar, H Lotková, T Garnol, Z Drahota, and Z ?ervinková “The Effect of tert-Butyl Hydroperoxide-Induced Oxidative Stress on Lean and Steatotic Rat Hepatocytes In Vitro” Oxidative Medicine and Cellular Longevity, Vol. 2014, ID 752506, 2014. Doi: doi.org/10.1155/2014/752506.
[19]. N Bhattarai, E Korhonen, M Toppila, A Koskela, K Kaarniranta, et al., Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells, Int. J. Mol. Sci. Vol. 21, issue. 6, 2020. Doi: doi.org/10.3390/ijms21062066.
[20]. D Joujeh, R Lahdo, A Ghrewaty, “Evaluation of Hemolytic and Anti-Hemolytic Activity of the Aerial Parts of Sonchus Oleraceus Extracts” International Journal of Pharmaceutical Sciences and Nanotechnology, vol. 10, no 3, 2017. Doi: doi.org/10.37285/ijpsn.2017.10.3.7.
[21]. Y Lai, H Li, S Yang, C Tu, H Cheng, and S Lan, “Food Supplement 20170307-EGR May Increase the Number of Mesenchymal Stem Cells and the Effect of Mitochondrial Protection,” J. Food Nutr. Res., vol. 5, issue. 8, pp. 569–574, 2017. DOI: 10.12691/jfnr-5-8-6.
[22]. D Grauzdyt?, A Pukalskas, W Viranaicken, C El Kalamouni, PR Venskutonis, Protective effects of Phyllanthus phillyreifolius extracts against hydrogen peroxide induced oxidative stress in HEK293 cells. PLoS ONE, vol. 13, issue. 11, pp. 1-15, 2018. Doi: doi.org/10.1371/journal.pone.0207672
[23]. K. Utispan, S. Koontongkaew, and N. Niyomtham, “Ethanolic extract of Ocimum sanctum leaf modulates oxidative stress, cell cycle and apoptosis in head and neck cancer cell lines,” Heliyon, Vol.9, Issue.4, pp.1-14, 2023. Doi: doi.org/10.1016/j.heliyon.2023.e15518.
[24]. S Paudel, T Nguyen, Y Kil, H Choi, J Jeong, J Nam. “Tricyclic diterpenes from the resin of Daemonorops draco and their activities on oxidative stress-induced mesenchymal stromal cells”, Phytochemistry Letters, Vol.50, pp.106-111, 2022. Doi: doi.org/10.1016/j.phytol.2022.05.012.
[25]. J Liu, X Li, J Lin, Y Li, T Wang, Q Jiang and D Chen. “Sarcandra glabra (Caoshanhu) protects mesenchymal stem cells from oxidative stress: a bioevaluation and mechanistic chemistry,” BMC Complement. Altern. Med., Vol.16, Issue.423, pp.1–10, 2016. Doi: 10.1186/s12906-016-1383-7.
[26]. X Li, X Xie, C Huang, Y Zhong, Y Li, J Zhou, D Chen “Repairing of oxidative damage to mesenchymal stem cell in rats and anti-lipidperoxidation by Plastrum Testudinis ethanolic extract”, Chinese Traditional and Herbal Drugs, Vol.38, Issue.7, pp.1043-1046, 2007.
[27]. L Bourebaba, I Michalak, M Röcken, K Marycz. “Cladophora glomerata methanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs),” Biomedicine & Pharmacotherapy, Vol.111, pp.6-18, 2019. Doi: doi.org/10.1016/j.biopha.2018.12.020.
[28]. M Ren, S Yang, J Li, Y Hu, Z Ren and S Ren, “Ginkgo biloba L. extract enhances the effectiveness of syngeneic bone marrow mesenchymal stem cells in lowering blood glucose levels and reversing oxidative stress,” Endocrine, Vol.43, pp.360–369, 2013.
[29]. A Wang, Q Yang, Q Li, X Wang, S Hao, J Wang, and M Ren. “Ginkgo Biloba L. Extract Reduces H2O2-Induced Bone Marrow Mesenchymal Stem Cells Cytotoxicity by Regulating Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways and Oxidative Stress”, Vol.24, pp.3159–3167, 2018. Doi: 10.12659/MSM.910718.
[30]. N Wang, F Wang, Y Gao, P Yin, C Pan, W Liu, et al., “Curcumin protects human adipose-derived mesenchymal stem cells against oxidative stress-induced inhibition of osteogenesis,” Journal of Pharmacological Sciences, Vol.132, Issue.3, pp.192-200, 2016. Doi: doi.org/10.1016/j.jphs.2016.10.005.
[31]. D Kim, D Kim, B Heck, M Shaffer, J Hur, and K Yoo, “A natural supplement formula reduces anti oxidative stress and enhances osteo chondrogenic differentiation potential in mesenchymal stem cells,” J. Clin. Biochem. Nutr., Vol.66, Issue.3, pp.206–212, 2020. Doi: 10.3164/jcbn.19-97.
[32]. F Perut, L Roncuzzi, S Avnet, A Massa, N Zini, S Sabbadini, F Giampieri, B Mezzetti and N Baldini. Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells. Biomolecules, Vol.11, Issue.87, 2021. Doi: doi.org/10.3390/biom11010087.
[33]. J Kim, J Lee, Y Han, J Lee, I Bae, Y Yoon, S Kwon, and S Lee. “Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells,” Biomol Ther, Vol.23, Issue.6, pp.517–524, 2015. Doi: dx.doi.org/10.4062/biomolther.2015.085.
[34]. Xiao-qing Song, Li-ning Su, Hui-ping Wei, Ying-hui Liu, Hai-feng Yin. “Protective Effects of Hydroxysafflor Yellow A against Oxidative Damage of ?-Mercaptoethanol During Neural Differentiation of Mesenchymal Stem Cells”. Chinese Herbal Medicines, Vol.9, Issue.3, pp.282-288, 2017. Doi: doi.org/10.1016/S1674-6384(17)60105-9.
[35]. B Zhao, Q Peng, D Wang, R Zhou, R Wang, Y Zhu, and S Qi. “Leonurine Protects Bone Mesenchymal Stem Cells from Oxidative Stress by Activating Mitophagy through PI3K/Akt/mTOR Pathway,” cells, Vol.11, Issue.1724, pp.1–20, 2022. Doi: doi.org/10.3390/cells11111724.
[36]. L Wang, Y Zhang, X Wang, L Ma, Y Zhang. “Naringin protects human adipose-derived mesenchymal stem cells against hydrogen peroxide-induced inhibition of osteogenic differentiation”. Chemico-Biological Interactions, Vol.242, pp.255-261, 2015. Doi: doi.org/10.1016/j.cbi.2015.10.010.
[37]. W Li, Y Liu, B Wang, Y Luo, N Hu, D Chen, X Zhang, and Y Xiong. “Protective effect of berberine against oxidative stress-induced apoptosis in rat bone marrow-derived mesenchymal stem cells,” Exp. Ther. Med., Vol.12, pp.4041–4048, 2016. Doi: 10.3892/etm.2016.3866.
[38]. A Patel, A Soni, and P Sharma “Effect of Tribulus terrestris saponins on proliferation of adipose-derived mesenchymal stem cells”. Journal of Cellular Biochemistry, Vol.120, Issue.6, pp.10082-10086, 2019. Doi: doi.org/10.1002/jcb.28291.
[39]. J Fang, X Zhao, S Li, X Xing, H Wang, P Lazarovici and W Zheng. “Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway,” Stem Cell Res. Ther., Vol.10, Issue.312, pp.1–18, 2019. Doi: doi.org/10.1186/s13287-019-1419-2.
[40]. H. Chen, Y. Huang, D. Huang, Z Wu, Y Li, C Zhou and G Wei. “Protective effect of gigantol against hydrogen peroxide induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K / Akt pathway,” Mol. Med. Rep., vol. 17, pp. 3267–3273, 2018. DOI: 10.3892/mmr.2017.8242.
[41]. J M M Andrade, N Maurmann, D V Lopes, D P Pereira, P Pranke, A T Henriques. “Rosmarinic and chlorogenic acid, isolated from ferns, suppress stem cell damage induced by hydrogen peroxide”. Journal of Pharmacy and Pharmacology, Vol.74, Issue.11, pp.1609–1617, 2022. Doi: doi.org/10.1093/jpp/rgac061.
[42]. J Shin, H Jeon, J Park, and M Chang, “Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2,” Int. J. Mol. Med., Vol.38, pp.1075–1082, 2016. Doi: 10.3892/ijmm.2016.2694.
[43]. W Zhao, X Liu, M Hu, Y Zhang, P Shi, J Wang, X Lu, X Cheng, Y Tao, X Feng, Y Wang, L Zhang. “Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis,” World J. Stem Cells, Vol.15, Issue.8, pp.842–866, 2023. Doi: 10.4252/wjsc.v15.i8.842.
[44]. S Li, H Bian, Z Liu, Y Wang, J Dai, W He, et al., “Chlorogenic acid protects MSCs against oxidative stress by altering FOXO family genes and activating intrinsic pathway”, European Journal of Pharmacology, Vol.674, Issues.2–3, pp.65-72, 2012. Doi: doi.org/10.1016/j.ejphar.2011.06.033.
[45]. P Thapa, Y Lee, T Nguyen, D Piao, H Lee, S Han, Y Lee, A Han, H Choi, J Jeong, J Nam,and E Seo. “Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells”. Molecules, Vol.26, Issue.1762, pp.1-10, 2021. Doi: doi.org/ 10.3390/molecules26061762.