Evaluation of immunomodulatory effect of Tinospora cordifolia leaf and stem on zidovudine induced immunotoxicity

G. Nageswari¹ , A. Harinatha Reddy² , B. Venkatappa³

1. Department of Microbiology, Sri Krishnadevaraya University, Anantapur, India.
2. Department of Microbiology, Sri Krishnadevaraya University, Anantapur, India.
3. Department of Microbiology, Sri Krishnadevaraya University, Anantapur, India.

Section:Research Paper, Product Type: Isroset-Journal
Vol.5 , Issue.3 , pp.1-5, Jun-2018

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v5i3.15

Online published on Jun 30, 2018

Copyright © G. Nageswari, A. Harinatha Reddy, B. Venkatappa . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
The present study was conducted to evaluate immunomodulatory effect of Tinospora cordifolia (T.C) leaf and stem extracts on zidovudine induced immunotoxicity. T.C leaves and stem was collected and three different extracts of stem and leaf (Aqueous, methanol, n-hexane) was prepared by Soxhlet extraction. Total 24 rats were used in the study. Rats were divided into 4 groups each of 6 rats. Group-I was treated with distilled water. Group-II rats received Zidovudine (500 mg/kg), Group-III given alcoholic extract of T.C stem (500 mg/kg) + Zidovudine (500 mg/kg) and Group-IV received alcoholic extract of T.C leaf (500 mg/kg) + Zidovudine (500 mg/kg). Physical and hematological and immunological parameters were measured at every alternative week. At the end of study rats were sacrificed under anesthesia. Thymus and spleen was collected and weighed. These findings suggest ameliorate effect of T.C leaf and stem extract on zidovudine induced immunotoxicity.

Key-Words / Index Term :
Zidovudine, alcoholic extract, immunomodulatory, immunotoxicity, haematological and histopathological

References :
[1]. P.S. Byadgi, “Vyadhiksamatwa. Parameswarappa’s Ayurvediya Vikriti Vigyan & Roga Vigyan, 1st edition, Volume 1. Varanasi, Chaukhambha Sanskrit Sansthan”, 292-305, (2007).
[2]. S. Preetam, K.D.H. Lohith, D. Chanda, S.P. Shubham, C. Ruplal, “ Traditional and ayurvedic foods of Indian origin”, Journal of Ethnic Foods, 2(3), 97-109, 2015.
[3]. E. Frederick, M.D. Harlass, “The pharmacology of zidovudine”, Primary care update, 3(2), 58-62, 1996.
[4]. S. Mahuya, D.S. Gauri, C. Biswajit, 2011, “Effects of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice”, BMC Complementary and Alternative Medicine, 11, 102-106, 2011.
[5]. R.S. Gupta, A. Sharma, “Anti-fertility effect of Tinospora cordifolia stems extract in male rats”, Indian Journal of Experimental Biology, 41(8), 885-889, 2003.
[6]. A.O. Naiho, K.M. Nwaokolo, M.O. Odigie, “ Zidovudine therapy: Effects on histology of kidney of Wistar rats” Israel Journal of Health Policy Research, 3(4), 60-67, 2014.
[7]. L. Lamperth, M.C. Dalakas, F. Dagani, J. Anderson, R. Ferrari, “Abnormal skeletal and cardic muscle mitochondria induced by zidovudine (AZT) in human muscle In vitro in an animal model”, Laboratory Investigation, 65(6), 742-751, 1991.
[8]. M.A. Kenneth, E. Walter E .Tucker, H. Gerald, D.M. Paulo, “ Nonclinical toxicology studies with zidovudine: Acute, sub acute and chronic toxicity in rodents, dogs and monkeys”, Fundamental And Applied Toxicology, 32, 129-139, 1996.
[9]. H.H.Chow, G. Brookshier, “Tissue deposition of zidovudine and its phosphorylated metabolites in zidovudine treated healthy and retrovirus infected mice”, Pharmaceutical Research, 15, 139-144, 1988.
[10]. P. Lakshmi Deepika, Jagadeesh, P. Supriya, Sowmya, “Analgesic, anti-inflammatory activity of Tinospora cordifolia and Valeriana Wallichi in Albino rats”, IOSR Journal of Pharmacy and Biological Sciences, 11(2), 18-22, 2016.