Prognostic Role of Preoperative Circulatory Immune Cells and ratio of Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Lymphocyte-to-Monocyte in Women with Breast Cancer of Saurastra, Gujarat Re

Priya Mehta¹ , Girish K Goswami² , Nimesh Rupala³

Section:Research Paper, Product Type: Isroset-Journal
Vol.5 , Issue.4 , pp.1-7, Aug-2018

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v5i4.17

Online published on Aug 31, 2018

Copyright © Priya Mehta, Girish K Goswami, Nimesh Rupala . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Cancer is one of the frequently talked and most feared diseases that have evolved, rather rapidly in the past two decades. Breast cancer, a multifactorial disease is the second most common malignancy related mortality among women worldwide. Routine diagnosis for breast cancer is usually done by mammography and histopathology, but current research data suggest that other non-disease specific biomarkers such as protein profiling, tumor specific hormones, hematocrit, serum proteins etc are also hypothesized to be associated with overall health outcome of the patients and can serve as a supplementary parameter to predict overall prognosis of the patients. The present study concerns about relative analysis of Hematocrit and WBC parameters among patients at the time of diagnosis along with the examination of ratio of Neutrophil-to-Lymphocyte (NLR), Platelet-to-Lymphocyte (PLR) and Lymphocyte-to-Monocyte (LMR) by fully automated clinical biochemistry analyzer and its correlation with other socio-demographic factors prevalent among the patients. For this purpose, preoperative blood samples of breast cancer patients were collected from Rajkot Cancer Hospital and results were compared with age and sex matched healthy volunteers. The present study conclude that high NLR ratio in 27%, high PLR ratio in 7.81 % and low LMR ratio in 14.75% of patients was obtained among the studied population.

Key-Words / Index Term :
Breast Cancer, Socio-demographic, WBC, NLR, PLR, LMR, prognosis

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