Evaluation of Immunomodulatory Effects of Silkworm (Bombyxmori L.) Cocoon Extracts 0n Methylprednisolone Induced Rats

Soumya M¹ , Harinatha Reddy² , NageswariG ³ , Venkatappa ⁴

Section:Research Paper, Product Type: Isroset-Journal
Vol.5 , Issue.6 , pp.80-88, Dec-2018

CrossRef-DOI:   https://doi.org/10.26438/ijsrbs/v5i6.8088

Online published on Jan 01, 2018

Copyright © Soumya M, Harinatha Reddy, NageswariG, Venkatappa . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
The present study aimed to evaluate the immunomodulatory effects of cocoon extracts of Silkworm on methylprednisolone drug induced immunosuppression in rats. Silkworm cocoons were collected and extracts were prepared. A total of 24 Wistar Albino rats divided into four groups were used in the study. Group-I rats were treated with distilled water. Group-II rats received Methyl prednisolone (20mg/kg), Group-III rats given cocoon extract of Silkworm (300mg/kg) + Methyl prednisolone(20mg/kg) and Group-IV received cocoon extract of Silkworm (500 mg/kg) + Methyl prednisolone (20mg/kg). Physical and immunological parameters were measured on 6th and 12th day. At the end of study rats were sacrificed under anesthesia. Spleen was collected , weighed and examined for histopathology. The results and findings of the study suggest the immune enhancement activity of cocoon extacts of Silkworm on methylprednisolone induced immunosuppression.

Key-Words / Index Term :
Cocoon extracts, immunomodulatory, methylprednisolone, immunosuppression, , immunological, histopathology

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