Volume-11 , Issue-5 , Oct 2024, ISSN 2455-3174 (Online)

• Open Access   Article

  Screening of Antioxidant Activity and Phytochemical Analysis of Bauhinia Racemosa Lam. Leaves Aqueous Extract

  Bhimraj Gawade, Dattatraya Jirekar, Babasaheb Zine

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.1-5, Oct-2024

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  Abstract
  The main objectives of this study were to screen the antioxidant activity, qualitative phytochemical analysis and LC-MS/MS analyses of aqueous extract material of Bauhinia racemosa Lam. plant leaves. The extract material afforded the rich content of various phytochemicals reported in qualitative phytochemical analysis, LC-MS/MS spectral analysis of the leaves extract material and antioxidant activity as a pharmacological activity. The extracted material was subjected to screen their antioxidant activity using DPPH in vitro system. Using DPPH (2, 2-Diphenyl-1-picrylhydrazyl) free radical scavenging assay, the aqueous extract material was found to have significant antioxidant activity with an IC50 value 44.18 ± 0.02 ?g/mL. A qualitative phytochemical analysis shows that the plant leaves material contains carbohydrate, protein, amino acids, tannins, saponin, flavonoids and phenolic compounds. It is concluded that the aqueous extract material of Bauhinia racemosa Lam. leaves have been significant antioxidant potential. Further study of extract material is needs to isolate and characterizes the bioactive antioxidants, which may serve as a potential source of natural bioactive antioxidants.

  Key-Words / Index Term
  Bauhinia racemosa Lam., phytochemical, LC-MS/MS, DPPH, antioxidant, pharmacological

  References
  [1] Pandey M. Rastogi S. Rawat A. Indian Herbal Drug for General Healthcare: An Overview. The Internet Journal of Alternative Medicine. Vol.6, Issue.1, pp.1-12, 2007.
  [2] Arulappan MT, Britto SJ, Thomas S, George M, Kindo I. Screening of the endangered medicinal plant extracts for antioxidant activity. The Pharma Innov. Journal. Vol.3, Issue.7, pp.38-43, 2014.
  [3] Kandasamy P, Manogaran S, Dhakshinamoorthy M, Kannan KP. Evaluation of antioxidant and antibacterial activities of endophytic fungi isolated from Bauhinia racemosa Lam and Phyllanthus amarus Schum and Thonn. J. Chem. Pharma. Res. Vol.7, Issue.9, pp.366-379, 2015.
  [4] Kumar G, Karthik L, Bhaskara Rao KV. Phytochemical composition and in vitro antimicrobial activity of Bauhinia Racemosa Lamk (Caesalpiniaceae). Int. J. Pharma. Sci. Res. Vol.1, Issue.11, pp.51-58, 2010.
  [5] Soni V, Jha AK, Dwivedi J, Soni P. Traditional uses, phytochemistry and pharmacology of Bauhinia racemosa Lam-a review. TANG / www.e-tang.org. Vol.5, Issue.4, pp.1-7, 2015.
  [6] Panda P, Das D, Dash P, Ghosh G. Therapeutic Potential of Bauhinia Racemosa - A Mini Review. Int. J. Pharm. Sci. Rev. Res. Vol.32, Issue.2, pp.169-179, 2015.
  [7] Krishnamoorthi R, Ratha Bai V. Phytochemical screening and antioxidant activity of Justicia tranquebariensis and Bauhinia Racemosa. Open Sci. J. Pharm. Pharm. Vol.3, Issue.2, pp.10-15, 2015.
  [8] Jeong S. Kim S. Kim D. Jo S. Nam K. Ahn D. Lee S. Effect of heat treatment on the antioxidant activity of extracts from citrus peels. J. Agric. Food Chem. Vol.52, pp.3389-3393, 2004.
  [9] Wong SP. Leong LP. Koh JHW. Antioxidant activities of aqueous extracts of selected plants. Food Chem. Vol. 99, pp. 775-783, 2006.
  [10] Blois MS. Antioxidant determination by the use of stable free radical. Nature. Vol.181, pp.1199-1200, 1958.
  [11] Shendge P. Patil L. Kadam V. In vitro evaluation antioxidant activities of Dillenia Indica Linn. leaf extract. Int. J. of Pharm. Sci. and Res. Vol.2, Issue.7, pp.1814-1818, 2011.
  [12] Gawade B, Fatema S, Gaikwad DD. Phytochemicals and Antioxidant Activity Investigation of Butea monosperma Lam. Leaves Ethanol Extract. To Chemistry Journal. Vol.6, pp.79-84, 2020.
  [13] Tiwari P. Kumar B. Kaur M. Phytochemical screening and extraction: A review. Int. Pharm. Sciencia. Vol. 1, Issue 1, pp. 98-106, 2011.
  [14] Gawade B, Farooqui M. Screening of phytochemicals and in vitro antidiabetic activity of Bauhinia racemosa Lam leaves. Asian Journal Pharmaceutical and Clinical Research. Vol. 11, Issue 6, pp. 190-193, 2018.
  [15] Kumar RS. Sivakumar T. Sunderam RS. Gupta M. Mazumdar UK. Gomathi P. Rajeshwar Y. Saravanan S. Kumar MS. Murugesh K. Kumar KA. Antioxidant and antimicrobial activities of Bauhinia racemosa L. stem bark. Braz. J. Med. Biol. Res. Vol. 38, Issue 7, pp. 1015-1024, 2005.
  [16] Sharanabasappa GK. Santosh MK. Shaila D. Seetharam YN. Sanjeevarao I. Phytochemical Studies on Bauhinia racemosa Lam., Bauhinia purpurea Linn. and Hardwickia binata Roxb. E-Journal of Chemistry. Vol. 4, Issue 1, pp. 21-31, 2007.
  [17] Pawar DS. Nasreen S. Phytochemical screening and antifungal activity of Bauhinia racemosa and Dolichandrone falcate. Int. J. App. Res. Vol. 2, Issue 8, pp. 243-245, 2016.
  [18] Akelesh T. Sam Johnson Udaya Chander J. Gopal V. Jose C. Manavalan R. Venkatanarayanan R. An updated review on Bauhinia racemosa Lam. and its medicinal properties. Eur. J. Biomed. Pharma. Sci. Vol. 4, Issue 5, pp. 482-488, 2017.
  [19] Akelesh T. Gopal V. Jeyabalan G. Sam Johnson Udaya Chander J. Manavalan R. Venkatanarayan R. Preliminary phytochemical screening of the extracts of Bauhinia racemosa Linn. World J. Pharm. Pharma. Sci. Vol. 6, Issue 9, pp. 1565-1572, 2017.
  [20] Rice-Evans CA. Miller NJ. Bolwell PG. Bramley PM. Pridham JB. The relative antioxidant activity of plant derived polyphenolic flavonoids. Free Radic. Res. Vol. 22, pp. 375-383, 1995.
  [21] Vijay C. Ramanathan M. Subburaj T. Sures B. Correlation of Phenolic Content and in Vitro Antioxidant Activity of certain herbal extracts. Indian Drugs. Vol.3, pp.453-455, 2002.
  [22] Rashed K. Butnariu M. Antimicrobial and antioxidant activities of Bauhinia racemosa Lam. and chemical content. Iranian J. Pharma. Res. Vol.13, Issue.3, pp.1073-1080, 2014.
  [23] Gawade B. Farooqui M. Antioxidant Activity from Ethanol Extract of Bauhinia racemosa Lam. Leaves. International Journal of Chemical and Physical Sciences. Vol.7, pp.67-72, 2018.
  [24] Badgujar NV. Mistry KN. Chudasama PN. Patel JS. In vitro Antioxidant and Cytotoxic Effects of Methanol Extracts of Vitex negundo, Lantana camara, Bauhinia variegata and Bauhinia racemosa on Human Cancer Cell lines. Indian J. Pharma. Sci. Vol.79, Issue.3, pp.431-437, 2017.
  [25] Bhimraj Gawade, Antioxidant activity and phytochemical analysis of aqua-ethanol extract of Bauhinia racemosa Lam. leaves. World Journal of Advanced Research and Reviews, Vol.21, Issue.3, pp.878-884, 2024.

  Citation
  Bhimraj Gawade, Dattatraya Jirekar, Babasaheb Zine, "Screening of Antioxidant Activity and Phytochemical Analysis of Bauhinia Racemosa Lam. Leaves Aqueous Extract," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.1-5, 2024

• Open Access   Article

  Synthesis, Characterization And Spectroscopic Study of New 3-{[(4,6-Dihydroxy Pyrimidin-2-yl)imino]methyl}Napthalen-2-ol Schiff-Base Ligand And It’s Transition Metal Complexes

  D.T. Sakhare

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.6-12, Oct-2024

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  Abstract
  In this work, new heterocyclic Schiff bases ligands derived from 2-amino-4,6-dihydroxypyrimidine with 2-hydroxy-1-naphthaldehyde (L?) was synthesized. These ligand used to synthesis complexes of Co(II) & Mn (II). The synthesized compounds have been characterized by FT-IR, 1H-NMR and UV-Vis techniques for the ligands and FT-IR, UV-Vis, all reactions monitored by TLC, molar conductivity and magnetic susceptibility measurements for the corresponding complexes. General formula of complexes are [M(L1)2(H2O)2] Where M= Co(II) & Mn(II). The complexe is paramagnetic. The results of the molar conductivity measurements indicated that all complexes are non-electrolytes in (DMSO). An octahedral geometry for all the complexes of. The ligands are bidentate, (L?) through phenolic (OH) and azomethine nitrogen. The ligand and its complexes were screened for their antifungal and antibacterial activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergllus flavus .and Escherichia coli, Salmonella typhi, Staphylococcus aureus, B. subtilis. The result indicated that the complexes exhibited good antifungal and antibacterial activities.

  Key-Words / Index Term
  Schiff bases, 2-hydroxy-1-naphthaldehyde, 2-amino-4,6-dihydroxypyrimidine, Antimicrobial Activity

  References
  [1] D.T.Sakhare, Synthesis, characterization of some transition metal complexes of bidentate Schiff base and their antifungal and antimicrobial studies,Advances in Applied Science Research, 6(6):pp.10-16, 2015.
  [2] C. Chandramouli, M.R. Shivanand, T.B. Nayanbhai, B. Bheemachari, R.H. Udupi, Synthesis and biological screening of certain new triazole schiff bases and their derivatives bearing substituted benzothiazole moiety, J Chem Pharm Res, 4, pp.1151-1159, 2012.
  [3] D. T. Sakhare, Synthesis, Characterization and Antimicrobial Activity of Schiff Base Derived from 2-Hydroxybenzaldehyde with 2-Amino-4,6-Dimethylpyrimidine And Their Transition Metal Complexes, GIS Science Journal, 9(4), pp.82-94, 2022.
  [4] R.Sliverstien, G.Bassler, T.Morrill, Spectrometric Identification of Organic Compounds. 7th addition, John Wiley, New York, 2005.
  [5] D.T.Sakhare, Copper Metal Complexes of a Pyrimidine Based Schiff Base Ligand Synthesis, Characterization and Biological Activity, Journal of Xidian University, 16(3), pp.191-201, 2022.
  [6] D.T.Sakhare, Synthesis, Characterization And Biological Studies of Aminopyrimidine Schiff Bases And Their Transition Metal Complexes, Dickensian Journal,22(4), pp.65-77, 2022.
  [7] D.T. Sakhare, Synthesis, characterization and biological activities of new bidentate Schiff base ligand and their Co (II) metal complexes, 2024, Materials Today: Proceedings,online.
  [8] Harshalata D., Dhongade H.J., Kavita C., Pharmacological potentials of pyrimidine derivatives: A review, Asian J. Pharm. Clin. Res., 8, pp.171-177, 2015.
  [9] D.T.Sakhare, Synthesis, Characterization and Antimicrobial Activity of Cu(II) Complexes Derived from Heterocyclic Schiff Bases Ligands, Asian Journal of Organic & Medicinal Chemistry, 7(2), pp.41-47, 2022.
  [10] Rana K., Kaur B., Kumar B., Synthesis and antihypertensive activity of some dihydropyrimidines, Indian J. Chem. B, 43, pp.1553–1557, 2004.
  [11] Atkins M., Jones C.A., Kirkpatrick P. Sunitinib maleate. Nat. Rev. Drug Discovry., 5, pp.279-280, 2006.
  [12] D.T. Sakhare, Synthesis, Characterization And In-Vitro Biological Activities of Novel Bidentate Schiff Base Ligand And Their Cobalt (II) Complexes. Juni Khyat , 13(07), No.03, pp.134-143, 2023.
  [13] Ramaling S., Belani C.P., Role of bevacizumab for the treatment of non-small-cell lung cancer. Future oncology, 3, pp.131-139,2007.
  [14] Harris P.A., Boloor A., Cheung M., Kumar R., Crosby R.M., Davis-Ward R.G., et al., Discovery of 5-[[4-[(2,3-dimethyl-2Hindazol-6-yl)methylamino]-2-pyrimidinyl] amino]-2-methylbenzenesulfonamide (Pazopanib), a Novel and potent vascular endothelial growth factor receptor inhibito, J. Med. Chem., 51, pp.4632-4640, 2008.
  [15] D.T. Sakhare, Synthesis,Characterization and Biological Activity of New Schiff Bases Derived from Aminopyrimidine and Their Metal Complexes, International Journal of Scientific Research in Science and Technology, 9(17), pp.160-173, 2022.
  [16] Lascombe M.B., Ponchet M., Venard P., Milat M.L., Blein J.P., Prange T., The 1.45 A resolution structure of the cryptogeincholesterol complex: a close-up view of a sterol carrier protein (SCP) active site, Acta Crystallogr. Sect. D, 58, pp.1442-1447, 2002.
  [17] Kappe C.O., 100 years of the biginelli dihydropyrimidine synthesis, Tetrahedron, 49, pp.6937-6963, 1993.
  [18] Espinet P., Esteruelas M.A., Oro L.A., Serrano J.L., Sola E., Transition metal liquid crystals: advanced materials within the reach of the coordination chemist, Coord. Chem. Reviews, 117, pp.215-274, 1992.
  [19] D.T. Sakhare, Synthesis, Characterization of some Cu (II) complexes of bidentate Schiff base and their antimicrobial studies, Journal of Medicinal Chemistry and Drug Discovery, 2(1), pp.583-597, 2016.
  [20] Osowole A.A., Festus C., Synthesis, Characterization,antibacterial and antioxidant activities of some heteroleptic metal(II) complexes of 3-{[-(pyrimidin-2-yl) Imino]methyl} napthalen-2-ol, J. Chem. Bio. Phy. Sci., 6, 080-089,2015.
  [21] Sönmez M., Sogukomerogullari H. G., Öztemel F.,Berber ?., Synthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes, Med. Chem. Res., 23, pp.3451–3457, 2014.
  [22] Gulcan M., Özdemir S., Dündar A., Ispir E., Kurtog ?lu M., Mononuclear complexes based on pyrimidine ring azo Schiff-Base ligand: synthesis, characterization, antioxidant, antibacterial, and thermal investigations, Z. Anorg. Allg. Chem, 640, pp.1754-1762, 2014.
  [23] Mildvan A.S., Cohn M., Kinetic and magnetic resonance studies of the pyruvate kinase reaction II complexes of enzyme, metal and substrates, J. Bio. Chem.,241, pp.1178-1193, 1966.
  [24] D.T. Sakhare, Synthesis, characterization and antimicrobial activities of some transition metal complexes of biologically active bidentate ligands, Inorganic Chemistry An Indian Journal,10(4), pp.142-147, 2015.
  [25] Tetteh S., Dodoo D.K., Appiah-Opong, R., Tuffour, I., Spectroscopic cha racterization, in vitro cytotoxicity, and antioxidant activity of mixed ligand palladium(II) chloride complexes bearing nucleobases, J. Inorg. Chem., pp.1-7 , 2014
  [26] D.T. Sakhare, Synthesis, characterization and in-vitro biological activities of Co (II) complexes of 2-(4-Methaylbenzylideneamino) Pyrimidine-4, 6-Diol. Current Pharma Research. ,9(4), pp.3335-3344, 2019.
  [27] D.T. Sakhare, Synthesis, Spectral, Thermal And Antimicrobial Activities of Mn (II) And Fe (III) Schiff Base Metal Complexes. International Journal of Current Research In Chemistry And Pharmaceutical Sciences, 2(7), pp.1-8, 2015.
  [28] A A Osowole1, R Kempe , R Schobert and S A Balogun , Candian journal of pure and applied sciences 4(2) pp.1169-1178, 2014.
  [29] A A Osowole . and R O Yoade , Scientific Journal Of Applied Research .; 4: pp.101-106, 2013.
  [30] D. T. Sakhare, Synthesis, characterization and antimicrobial activities of some Mn(II) and Fe(III) complexes of biologically active bidentate ligands, Journal of Chemical and Pharmaceutical Research, 7(6), pp.198-204, 2015.
  [31] M Usharani. E Akila, And R Rajavel. International Journal of Recent Scientific Research , 4( 9): pp.1385-1390, 2013.
  [32] J.A. Dean, Lange’s Hand Book of Chemistry, 14th ed., Megraw-Hill, New York, p.35, 1992.
  [33] Housecroft, C.E., Sharpe, A.G.: Inorganic Chemistry, 2nd edn.Pearson, England , 2005.
  [34] D.T. Sakhare, Synthesis, Characterization And Antimicrobial Studies of Some Transition Metal Complexes of Schiff Bases, International Journal of Current Research In Chemistry And Pharmaceutical Sciences, 2(6), pp.28–34.2015.
  [35] Avaji P G, Reddy B N and Patil S A, Trans. Met. Chem., 31, 842, 2006.
  [36] D.T.Sakhare, .Synthesis,Characterization And Antimicrobial Studies On Schiff Base Derived From 2-Amino 4,6- Dihydroxypyrimidine And Benzaldehyde And Its Cobalt Complexes, International Journal of Food And Nutrition Science, 11(S1), pp.970-982, 2022.
  [37] D. T. Sakhare, Syntheses, characterization of some transition metal complexes of bidentate schiff base and their antimicrobial activities, Der Chemica Sinica, 6(6): pp.1-6, 2015.
  [38] D.T. Sakhare, Synthesis, characterization and antimicrobial activities of some Mn(II) and Fe(III) complexes of biologically active bidentate ligands, Journal of Chemical and Pharmaceutical Research, 7(6), pp.198-204, 2015.

  Citation
  D.T. Sakhare, "Synthesis, Characterization And Spectroscopic Study of New 3-{[(4,6-Dihydroxy Pyrimidin-2-yl)imino]methyl}Napthalen-2-ol Schiff-Base Ligand And It’s Transition Metal Complexes," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.6-12, 2024

• Open Access   Article

  Synthesis, Characterization and Evaluation of Biological Activity of 1, 3, 4- Thiadiazole Derivatives Containing Schiff Bases

  Rajpal Jadhav, Hansaraj Joshi, Ramesh Ware, Sanjay Ubale

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.13-18, Oct-2024

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  Abstract
  Synthesis of Schiff bases via conventional methods is described, involving the condensation reaction between aldehyde and 1, 3, 4-thiadiazole 2-amine. After purification and characterization, seven Schiff bases (5a-5g) were successfully synthesized. Physical characteristics were recorded, and purity was confirmed through various techniques including TLC, melting point determination, elemental analysis, FT-IR, 1H-NMR, and mass spectral studies. FT-IR spectra showed characteristic peaks confirming the formation of Schiff bases, while 1H-NMR spectra provided insights into molecular structure. Biological screening against bacterial species revealed varying degrees of antibacterial activity, with compounds 5e, 5f, and 5g exhibiting notable effectiveness against E. coli. Structure-activity relationship analysis suggested that electron-withdrawing groups enhance antibacterial potency. Additionally, some compounds demonstrated strong antifungal effects against various fungi, indicating the potential of these compounds as antimicrobial agents. Further research is warranted to elucidate their mechanisms of action and explore additional properties before considering them for medicinal use.

  Key-Words / Index Term
  Schiff bases, 1, 3, 4-thiadiazole 2-amine, biological activity etc

  References
  [1] S. Shamaila, N. Zafar, S. Riaz, R. Sharif, et. al., ““Gold Nanoparticles: An Efficient Antimicrobial Agent against Enteric Bacterial Human Pathogen”, Nanomaterials, Vol.6, pp.71, 2016.
  [2] T. Hava Lofton, “Mechanisms and Biological Costs of Bacterial Resistance to Antimicrobial Peptides” Ph.D. dissertation, Abbrev. Faculty of Medicine, Uppsala Univ., City of Univ., Abbrev. State, 2016.
  [3] S. Talath, AK. Gadad, “Synthesis, antibacterial and antitubercular activities of some 7- [4-(5-amino- [1,3,4] thiadiazole-2-sulfonyl)- piperazin1-yl] fluoroquinolonic derivatives“, Eur. J. Med Chem., Vol.41, pp.918-24, 2006
  [4] O. Pintilie, L. Profire, V. Sunel, et al., “Synthesis & Antimicrobial Activity of Some New 1,3,4-Thiadiazole & 1,2,4- Triazole Compounds Having a D, L-Methionine Moiety“, Molecules, Vol.12, pp.103-13, 2007.
  [5] A. Foroumadi, A. Rineh, S. Emami, F. Siavoshi, S. Massarrat, F. Safari et al., “Synthesis & anti-Helicobacter pylori activity of 5- (nitroaryl)-1,3,4- thiadiazoles with certain sulfur containing alkyl side chain Paper title“, Bio-org Med. Chem. Lett, Vol.18, pp. 3315-15, 2008.
  [6] A. Foroumadi, S. Emami, A. Hassanzadeh, M. Rajaee, K. Sokhanvar, MH. Moshafi et. al., “Synthesis & antibacterial activity of N- (5-benzylthio-1, 3, 4- thiadiazol-2-yl) and N-(5- benzylsulfonyl-1, 3, 4-thiadiazol-2- yl) piperazinyl quinolone derivatives,” Bio-org Med. Chem. Lett, Vol.15, No 5, pp.4488-92, 2005.
  [7] P. Mishra, H. Rajak, “Performance Analysis of Reactive and Proactive Routing Protocols for Mobile Ad-hoc N/W,” World Academics Journal of Engineering Sciences, Vol.1, No 5, pp.1-4, 2013.
  [8] U. S. Goksen, N. G. Kelekci, O. Goktas, Y. Koysal, E. Kilic, S. Isik, G. Aktay, M. Ozalp, “1-Acylthiosemicarbazide, 1,2,4- triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl -2-benzoxazolines : Synthesis, analgesic anti-inflammatory and antimicrobial activities,” Bioorganic & Medicinal Chemistry, Vol.15, No 5, pp.5738-5751, 2007.
  [9] E. Palaska, G. Sahin, P. Kelicen, N.T. Durlu, G. Altinok “Synthesis and anti-inflammatory activity of 1-acylthiosemicarbazides, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazole-3-thiones,” Farmaco, Vol.57, No.2, pp.101-107, 2002.
  [10] A. E. Gazzar, M I Hegab “Bioorganic and Medicinal Chemistry Letters,” World Academics Journal of Engineering Sciences, Vol.18, No 5, pp.4538-4543, 2008.
  [11] A. Aziem, “J. Heterocycl. Chem.,” International Journal of Scientific Research in Biological Sciences, Vol. 52, Issue 1, pp.251, 2015. Anti-malarial [Li, Y., Yang, Z., Zhang, H., Cao, B., Wang, F., Zhang, Y., Shi, Y., Yang, J., and Wu, B., Bioorg. Med. Chem., Vol.11, No.20, p. 4363, 2003.
  [12] L. Shi, HM Ge, SH Tan, HQ Li, YC Song, HL Zhu, RX Tan, “Synthesis & antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde,” European Journal of Medicinal Chemistry, Vol.42, No 4,pp.558-564, 2007.
  [13] S. Hussain, J. Sharma, M. Amir, “Synthesis and antimicrobial activities of 1, 2, 4-triazole and 1, 3, 4-thiadiazole derivatives of 5-amino-2-hydroxybenzoic acid,” E-Journal of Chemistry, Vol.5, No 4, pp.963-968, 2008.
  [14] P. Pattanayak, R. Sharma, P. K.Sahoo, “Synthesis and evaluation of 2-amino-5-sulfanyl-1, 3, 4-thiadiazole as antidepressant, anxiolytic, and anticonvulsant agents,” World Academics Journal of Engineering Sciences, Vol.18, No.1, pp.551-561, 2009.
  [15] D.M. Bailey, et.al. “Redox regulation of neurovascular function by acetazolamide: complementary insight into mechanisms underlying high-altitude acclimatiation,” The Journal of Physiology, Vol.15, No.5, pp.3637, 2012.
  [16] P.A. Datar, T.A. Deokule, “Design and Synthesis of Thiadiazole Derivatives as Antidiabetic Agents,” Med. Chem, Vol.4, No.4, pp.390-399, 2014.
  [17] S. Ren, R. Wang, K. Komatsu, P. Bonaz-Krause, Y. Zyrianov, C.E. McKenna, C. Csipke, Z.A. Tokes, & E.J. Lien, “Synthesis, biological evaluation, and quantitative structure? activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents,” Journal of medicinal chemistry, Vol.45, No 2, pp.410-419, 2002.
  [18] M. J. Hearn, M.H. Cynamon, “Design and synthesis of antituberculars: preparation and evaluation against Mycobacterium tuberculosis of an isoniazid Schiff base,” Journal of Antimicrobial Chemotherapy, Vol.53, No 5, pp.185-191, 2004.
  [19] M.S. Karthikeyan, D.J. Prasad, B. Poojary, B.K. Subrahmanya, B.S. Holla, & N.S. Kumari, “Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety,” Bioorganic & Medicinal Chemistry, Vol.14, No.22, pp.7482-7489, 2006.
  [20] R. K. Saksena, S. Puri, Indian Journal of Heterocyclic Chemistry, Vol.13, No.5, pp.127-130, 2003.
  [21] M. Bulbul, N. Sarcoglu, et.al, “Bile acid derivatives of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibition effects,” Bioorganic & Med. Chemistry, Vol.10, No.8, pp.2561-2567, 2002.
  [22] L.D. S. Yadav, S. Saigal, “A facile ring transformation of 5-oxazolone derivatives to new 1, 3, 4-oxa (thia)diazolo[3,2-a]pyrimidin-5-ones,” Indian Journal of. Chemistry, Vol.34B, No.5, pp.500-503, 1995.
  [23] S. Rajesh, P. Ganesh, S. Jitendra, & C. Subhash, “Synthesis and biological evaluation of 2-amino-5-sulfanyl-1, 3, 4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents,” Medicinal Chemistry Research, Vol.20, No, pp.245-253, 2011.
  [24] Z. Cimerman, S. Miljanic & N. Galic, “Schiff Bases Derived from Aminopyridines as Spectrofluorimetric Analytical Reagents,” Croatica Chemica Acta, Vol.73, No.1, pp.81-95, 2000.
  [25] S. Malik, B. Nema, “Antimicrobial activities of Schiff Bases: A review,” International Journal of Theoretical & Applied Sciences, Special Issue-NCRTAST Vol.8, No.1, pp.28-30, 2016.
  [26] J. Sunny, J. Anil, G. Avneet & Hemraj, “Synthesis, Biological Activities and Chemistry of Thiadiazole Derivatives and Schiff Bases,” Asian Journal of Pharmaceutical and Clinical Research, Vol.5, No.3, pp.199-208, 2012.
  [27] J. Mohan, G. Anjaneyulu, R, Kiran, “Synthesis of 2-alkyl-6- aryl-imidazo (2, 1- b)-1, 3, 4-thiadiazoles & their 5-bromo derivatives for antimicrobial activity,” Journal of the Indian Chemical Society, Vol.66, No.1-6, pp.118--122, 1989.
  [28] A. A. Fawzia, N S. Habib, S. Nargues, Mel Taibbi, S. Dine, A. S. E. Dine, “Synthesis of imidazo(2, 1-b)-1, 3, 4-thiadiazole derivatives as antibacterial agents against Escheria coli & Candida albicans,” Chem. Abst, 1991.
  [29] B. S. Holla, K.N. Poorjary, B.S. Rao, M.K. Shivananda, “New bis-aminomercaptotriazoles & bis-triazolothiadiazoles as possible anticancer agents,” European Journal of Medicinal Chemistry, Vol.37, No.6, pp.511-517, 2002.
  [30] E. Yousif, A. Majeed, K. Al-Sammarraeb, N. Salih, J. Salimon, B. Abdullah, “Metal complexes of Schiff base: Preparation, characterization & antibacterial activity,” Arabian Journal of Chemistry, Vol.10, pp.1-6, 2017.
  [31] M. N. Mousa, “Synthesis, Characterization & evaluation of antibacterial activity of 1,3,4- Thiadiazole derivatives containing Schiff bases,” International Journal of Pharmaceutical, Chemical and Biological Sciences, Vol.7, No.1, pp.71-76, 2017.
  [32] R.J. Cruickshank; R. R. Duguid, “Swain Medical,” First Edition, Med. Microbiology, Churchill Livingstone, 1998.
  [33] M. N. Mousa, “Synthesis, Characterization, & Biological Evaluation of Antibacterial Activity of 4H 1,2,4-triazole-5-(4- Bromophenoxymethyl)- 3-(4-substituted Benzyl) sulfide,” Biological Forum– An International Journal, Vol.1, No.5, pp.1-4, 2013.
  [34] R.L. Jadhav, H.U. Joshi, S.B. Ubale, “Synthesis, characterization and biological activities of some novel Schiff bases derived from 3-acetyl-4-hydroxy-2H-chromen-2-one and 5-(4-substituted phenyl)-1,3,4-thiadiazol-2-amine,” Journal of Interdisciplinary Cycle Research, Vol. XIII, No X, pp.414-424, 2021.
  [35] R.L Jadhav., H.U. Joshi, S.B. Ubale, “Synthesis, characterization and biological activities of some novel Schiff bases derived from 3-acetyl-4-hydroxy-2H-chromen-2-one and 2- amino 5-(4-halo substituted phenyl)-1, 3, 4-thiadiazole,” The International journal of analytical and experimental modal analysis, Vol. XIII, No XI, pp.452-464, 2021.
  [36] V. Mutalik, M. A. Phanibandb, “Synthesis, characterization, fluorescent and antimicrobial properties of new Lanthanide(III) complexes derived from coumarin Schiff base,” Journal of Chemical and Pharmaceutical Research, Vol.3, No.2, pp.313-330, 2013.

  Citation
  Rajpal Jadhav, Hansaraj Joshi, Ramesh Ware, Sanjay Ubale, "Synthesis, Characterization and Evaluation of Biological Activity of 1, 3, 4- Thiadiazole Derivatives Containing Schiff Bases," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.13-18, 2024

• Open Access   Article

  Formation of Copper Metal Complexes with Medicinal Drugs in Ethanol Water Media

  Ramesh Ware, Kishore Koinkar, Ashish Katariya, Hansaraj Joshi, Shailendrasingh Thakur

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.19-22, Oct-2024

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  Abstract
  The stability constant of seven medicinal drugs with copper metal ion were investigate using pH metric titration technique in 20% (v/v) ethanol-water mixture at 300 K temperature and at an ionic strength of 0.1M NaClO4. {Metal to ligand ratio = 1:5 and 1:1} The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton- ligand pKa and metal-ligand stability constant logK values. It is observed that copper metal ion forms 1:1 and 1:2 complexes.

  Key-Words / Index Term
  Stability Constant, copper metal, medicinal drugs, pH metry

  References
  [1] Shailendrasingh Thakur, S.A. Peerzade, A.J.Khan, R.L.Ware, “Mixed ligand complexes of zinc metal ion with antibacterial drug Isoniazid and some amino acids in aqueous solution.” International Multilingual Research Journal Printing Area, (Special Issue), pp.47-51, 2017.
  [2] Ramesh L. Ware, Kishore N. Koinkar, Shailendrasingh V. Thakur, “Mixed ligand complex formation of Copper metal ion with some amino acids and drug Efavirenz in ethanol-water medium.” International Journal of Universal Science and Technology, Vol. 3, Issue 6, pp-284-288, 2018
  [3] Ramesh Ware, Shoeb Peerzade and Shailendrasingh Thakur, “Potentiometric investigation of complexation of Benazepril hydrochloride drug with transition metal ions.” International Journal of Universal Science and Technology, Vol. 3, Issue 5, pp-238-241, 2018.
  [4] Ramesh Ware and Shailendrasingh Thakur, “Mixed ligand complexes of Copper metal ion with drug Diphenhydramine hydrochloride drug and amino acids in aqueous media.” International Journal of Universal print, Vol. 4, Issue 4, pp-254-260, 2018.
  [5] Ramesh Ware, Shoeb Peerzade and Shailendrasingh Thakur, “pH metric investigation of complexation of Ibuprofen drug with transition metals in mixed solvent media.” International Journal of Universal print, Vol. 4, Issue 5, pp-274-278, 2018.
  [6] Shailendrasingh Thakur, Mazahar Farooqui, Ramesh Ware, “Mixed ligand complexes of Zinc metal ion with drug Cefotaxime and amino acids in aqueous media.” International Journal of Advance and Innovative Research, Vol. 6, Issue 1(XVI), pp-228-232, 2019.
  [7] Shailendrasingh Thakur and Ramesh Ware, “Mixed Ligand Complexes of Copper Metal Ion with Ibuprofen Drug and Amino Acids in Aqueous Medium.” Journal of Global Resources, Vol. 5, Special Issue 2, pp-224-229, 2019.
  [8] Ramesh Ware and Shailendrasingh Thakur, “pH Metric Study of Mixed Ligand Complexes of Cadmium Metal ion With Benazepril Drug and Amino Acids in 20% (v/v) Ethanol-water Medium.” Journal of Global Resources, Vol. 5, Special Issue 2, pp-265-269, 2019.
  [9] Ramesh Ware, P.P.Ghumare, D.B.Jirekar, Shailendrasingh Thakur, “Mixed Ligand Complexes of Cadmium Metal Ion With Ibuprofen Drug and Amino Acids in Aqueous Medium.” RESEARCH JOURNEY International Multidisciplinary E-Research Journal, Special Issue 199, pp- 64-70, 2019.
  [10] Shailendrasingh Thakur, H.U.Joshi, M.A. Sakhare, Ramesh Ware, “Mixed Ligand Complexes of Cadmium Metal Ion With Diphenhydramine and Amino Acids in Aqueous Medium.” RESEARCH JOURNEY International Multidisciplinary E-Research Journal, Special Issue 199, pp-71-77, 2019.
  [11] Rajpal Jadhav, Ramesh Ware, Shailendrasingh Thakur, “Potentiometric investigation of complexation of Benazepril drug with alkaline earth metal ions in aqueous media.” Journal of Research and Development, Vol. 10, Special Issue 02, pp-40-42, 2020.
  [12] Ramesh Ware, MA Sakhare, Shukat Patel, Shailendrasingh Thakur, “Complexation of lisinopril drug with alkaline earth and transition metal ions in mixed solvent media.” Innovare Journal of sciences, Vol. 8, Special Issue 1, pp-132-133, 2020.
  [13] Ramesh Ware, D. B. Jirekar, P. P. Ghumare, Shailendrasingh Thakur, “Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media.” To Chemistry Journal, Vol. 6, pp-69-72, 2020.
  [14] Shailendrasingh Thakur, M. A. Sakhare, D. B. Jirekar, P. P. Ghumare, Ramesh Ware, “Studies of Complexation of Transition Metal Ions With Benazepril Drug in Aqueous Media: Thermodynamic Aspect.” To Chemistry Journal, Vol. 6, pp-73-78, 2020.
  [15] Ramesh Ware, Hansaraj Joshi, Rafeeque Shaikh, Shailendrasingh Thakur, “Thermodynamic Study of the formation of transition metal ion Complexes Carrying medicinal drug in mixed solvent media” Journal of Science and Technology, Vol. 7, Special Issue 3, pp-103-108, 2022.
  [16] Ramesh Ware, Kishore Koinkar, Ashish Katariya, Shailendrasingh Thakur, “Formation of alkaline earth and transition metal complexes with labetalol drug in ethanol water medium,” Int Journal of Scientific Research in Chemistry, Vol. 9, Issue 7, pp-243-246, 2024

  Citation
  Ramesh Ware, Kishore Koinkar, Ashish Katariya, Hansaraj Joshi, Shailendrasingh Thakur, "Formation of Copper Metal Complexes with Medicinal Drugs in Ethanol Water Media," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.19-22, 2024

• Open Access   Article

  Synthesis of Isoquinolines Using Copper Nanoparticles Supported on Carbon Microsphere Cu-NP/C/PEG-400 as Heterogeneous Reusable Catalyst

  Shrinivas L. Nakkalwar, Hanmant M. Kasralikar, Nitish S. Kaminwar

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.23-28, Oct-2024

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  Abstract
  A new, eco-friendly method for synthesizing 1-Phenyl Isoquinoline derivatives has been developed using Cu-NP/C/PEG-400 as a heterogeneous, reusable catalyst. This method involves the activation of C-H and N-N bonds in 1-(diphenylmethylene) hydrazine and substituted aryl acetylenes. The process utilizes Cu-NP/C as an oxidant and AgSbF6 as an additive, all within a biodegradable PEG-400 solvent. This approach offers several advantages, including a straightforward extraction procedure, high atom economy, a wide substrate scope, and high product yields, making it an efficient and sustainable protocol for producing isoquinoline derivatives.

  Key-Words / Index Term
  Green synthesis, Heterogeneous catalyst, Cu-NP/C, Biodegradable solvent

  References
  [1] G. Zeni, R.C. Larock, “Synthesis of Heterocycles via Palladium ?-Olefin and ?-Alkyne Chemistry”, Chemical Reviews, Vol.104, Issue.5, pp.2285–2310, 2004,
  [2] I.Nakamura,Y. Yamamoto, “Transition-Metal Catalyzed Reactions in Heterocyclic Synthesis”, Chemical Reviews, Vol.104, Issue.5, pp.2127–2198, 2004,
  [3] K. R. Roesch, R.C. Larock, “Synthesis of Isoquinolines and Pyridines via Palladium-Catalyzed Iminoannulation of Internal Acetylenes”, The Journal of Organic Chemistry, Vol.63, Issue.16, pp.5306–5307, 1998,
  [4] Q.Huang, J.A. Hunter, R.C. Larock, “Synthesis of isoquinolines and naphthyridines by electrophilic ring closure of iminoalkynes”, Organic Letters, Vol.3, Issue.19, pp.2973–2976, 2001,
  [5] K. R. Roesch, H. Zhang, R.C.Larock, “Synthesis of Isoquinolines and Pyridines by the Palladium-Catalyzed Iminoannulation of Internal Alkynes”, The Journal of Organic Chemistry, Vol.66, Issue.24, pp.8042–8051, 2001.
  [6] R.P. Korivi, C.H. Cheng, “Highly Efficient Synthesis of Isoquinolines via Nickel-Catalyzed Annulation of 2-Iodobenzaldimines with Alkynes:? Evidence for Dual Pathways of Alkyne Insertion”, Organic Letters, Vol.7, Issue.23, pp.5179–5182, 2005.
  [7] R.P. Korivi,Y.C.Wu, C.H.Cheng,, “Isoquinolinium Salts from o-Halobenzaldehydes, Amines, and Alkynes Catalyzed by Nickel Complexes: Synthesis and Applications”, Chemistry Europe, Vol.15, Issue.41, pp.10727–10731, 2009.
  [8] D. A. Colby; R. G.Bergman, J. A. Ellman, “Rhodium-Catalyzed C?C Bond Formation via Heteroatom-Directed C?H Bond Activation”, Chemical Reviewes, Vol.110, Issue.2, pp.624–655, 2010.
  [9] S.H.Cho, J.Y. Kim, J. Kwak, S. Chang, “Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation”, Chemical Society Reviewes, Vol.40, pp.5068–5083, 2011.
  [10] L. Ackermann, “Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope”, Chemical Reviewes, Vol.111, 3, pp.1315–1345, 2011.
  [11] J. Wencel-Delord, T. Dro?ge, T. F. Liu, F. Glorius, “Towards mild metal-catalyzed C–H bond activation”, Chemical Society Reviews, Vol.40, Issue.9, pp.4740-4761, 2011.
  [12] P.B. Arockiam, C. Bruneau, P. H. Dixneuf, “Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization”, Chemical Reviewes, Vol.112, Issue.11, pp.5879–5918, 2012.
  [13] R. He, Z.T. Huang, Q.Y. Zheng, C. Wang, “Isoquinoline skeleton synthesis via chelation-assisted C-H activation”, Tetrahedron Letters, Vol.55, Issue.42, pp.5705–5713, 2014.
  [14] A. Kulkarni, Daugulis, “Direct Conversion of Carbon-Hydrogen into Carbon-Carbon Bonds by First-Row Transition-Metal Catalysis”, Synthesis, Vol.24, pp.4087–4109, 2009.
  [15] Y. Nakao, “Hydroarylation of alkynes catalyzed by nickel”, The Chemical Record, Vol. 11, Issue.5, pp.242–251, 2011.
  [16] J. Miao, H. Ge, “Recent Advances in First-Row-Transition-Metal-Catalyzed Dehydrogenative Cou¬pling of C(sp3)–H Bonds”, European Journal of Organic Chemistry, Vol.2015, Issue.36, pp.7859–7868, 2015.
  [17] B.Sun, T. Yoshino, M. Kanai, S. Matsunaga, “Cp*CoIII Catalyzed Site-Selective C-H Activation of Unsymmetrical O-Acyl Oximes: Synthesis of Multisubstituted Isoquinolines from Terminal and Internal Alkynes”, Angewandte Chemie International Edition, Vol. 54, Issue.44, pp.12968–12972, 2015.
  [18] H. Wang, J. Koeller, W. Liu, L. Ackermann, “Cobalt(III)-Catalyzed C-H/N-O Functionalizations: Isohypsic Access to Isoquinolines”, Chemistry A European journal, Vol.21, Issue.44, pp.15525–15528, 2015.
  [19] M. Sen, D. Kalsi, B. Sundararaju, “Cobalt(III)-Catalyzed Dehydrative [4+2] Annulation of Oxime with Alkyne by C-H and N-OH Activation”, Chemistry A European journal, Vol.21, Issue.44, pp.15529–15533, 2015.
  [20] S.S.Zhang, X.G. Liu, S.Y.Chen, D.H. Tan, C.Y. Jiang, J.Q. Wu, Q. Li, H. Wang, “(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N-H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines”, Advanced Synthesis and Catalysis, Vol.358, Issue.10, pp.1705–1710, 2016.
  [21] J.Li, M. Tang, L. Zang, X. Zhang, Z. Zhang, L. Ackermann, Amidines for Versatile Cobalt(III)-Catalyzed Synthesis of Isoquinolines through C-H Functionalization with Diazo Compounds”, Organic Letters, Vol.18, pp.2742–2745, 2016.
  [22] F. Wang, Q.Wang, M.Bao, X. Li, “Cobalt-catalyzed redox-neutral synthesis of isoquinolines: C-H activation assisted by an oxidizing N-S bond”, Chinese Journal of Catalysis, Vol.37, Issue.8, pp.1423–1430, 2016.
  [23] A. B. Pawar, A. Darpan, D. M. Lade, “Cp*Co(III)-Catalyzed C–H/N–N Functionalization of Arylhydrazones for the Synthesis of Isoquinolines”, The Journal of Organic Chemistry, Vol.81, Issue.22, pp.11409–11415, 2016.
  [24] T. Satoh, M. Miura, “Oxidative Coupling of Aromatic Substrates with Alkynes and Alkenes under Rhodium Catalysis”, Chemistry A European Journal, Vol.16, Issue.37, pp.11212–11222, 2010.
  [25] K. Parthasarathy, M. Jeganmohan, C.H. Cheng, “Rhodium-catalyzed one-pot synthesis of substituted pyridine derivatives from ?, ?-unsaturated ketoximes and alkynes”, Organic Letters, Vol.10, Issue.2, pp.325-328, 2008.
  [26] P. C. Too, Y.F. Wang, S. Chiba, “Rhodium(III)-Catalyzed Synthesis of Isoquinolines from Aryl Ketone O- Acyloxime Derivatives and Internal Alkynes”, Organic Letters, Vol.12, Issue.24, pp.5688-5691, 2010.
  [27] L. Ackermann, A.V. Lygin, N. Hofmann, “Ruthenium- Catalyzed Oxidative Annulation by Cleavage of C-H/N- H Bonds”, Angewandte Chemie International Edition, Vol.50, Issue.28, pp.6379-6382, 2011.
  [28] L. Ackermann, J. Pospech, K. Graczyk, K. Rauch, “Versatile synthesis of isocoumarins and ?-pyrones by ruthenium-catalyzed oxidative C–H/O–H bond cleavages”, Organic Letters, Vol.14, Issue-3, pp.930-933, 2012.
  [29] C. Ravi Kiran, P. Sandeep, J. Masilamani, “Alkynes by C-H bond activation: A practical route to synthesize substituted Isoquinolines” , Organic Letters, Vol.14, Issue.12, pp.3032-3035, 2012.
  [30] M. Rajendran ,T. Masilamani, J. Masilamani, , “Ruthenium(II)- Catalyzed Redox-Neutral Oxidative Cyclization of Benzimidates with Alkenes with Hydrogen Evolution”, Organic Letters, Vol.19, Issue.14, pp.6678?6681, 2017.
  [31] D.S. Deshmukh, B. M. Bhanage, “Cp*Co(III)-catalyzed annulation of azines by C–H/N–N bond activation for the synthesis of isoquinolines”, Organic and Biomolecular Chemistry, Vol.17, pp.3489-3496, 2017.
  [32] S. Zhang, D. Huang, G. Xu, S. Cao, R. Wang, S. Peng, J. Sun, “An Efficient Synthesis of Isoquinolines via Rhodium-Catalyzed Direct C-H Functionalization of Arylhydrazines”, Organic and Biomolecular Chemistry, Vol.13, Issue.29, pp.7920-7923, 2015.

  Citation
  Shrinivas L. Nakkalwar, Hanmant M. Kasralikar, Nitish S. Kaminwar , "Synthesis of Isoquinolines Using Copper Nanoparticles Supported on Carbon Microsphere Cu-NP/C/PEG-400 as Heterogeneous Reusable Catalyst," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.23-28, 2024

• Open Access   Article

  One-Pot Three Component Synthesis of some 8-Benzeloxy-5-{2-[N-(2-Chloro-Quinolin-3yl -Methelene)-Hydrazino]-Thiazole-4-yl}c-1H-Quinoline 2-Ones

  Fahad T. Saleh, Abdul Ahad, Anis Ahmed, Syed Ummul Khair Asema

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.29-32, Oct-2024

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  Abstract
  Synthesis of a new series of 8-Benzeloxy-5-{2-[N-(2-chloro-quinolin-3ylmethelene)-hydrazino] is investigated in this work. One-pot multicomponent synthesis of -thiazole-4-yl-1H-quinoline-2-one was achieved by condensation of substituted 2. Chloroquinoline thiosemicarbazide, -3-carbaldehydes, and 8-benzyloxy-5-(2-bromo-acetyl)-1H-quinolin-2-one.

  Key-Words / Index Term
  Multicomponent synthesis, quinoline, thiazole,maxium yields, room temperature conditions

  References
  [1] S. Raut, A Tidke, B. Dhotre, P.M. Arif, “Different strategies to the synthesis of indazole and its derivatives: A review”, Mini-Reviews in Organic Chemistry, Vol.17, Issue.4, pp.363-404, 2020.
  [2] T.S. Choudhare, D.S. Wagare, V. Jagrut, P. Netankar, “Three Component One-Pot Synthesis of Novel 8-Benzyloxy-5-{2-[N?-(1, 3-Diphenyl-1 H-Pyrazol-4-Ylmethylene)-Hydrazino]-Thiazol-4-yl}-3, 4-Dihydro-1 H-Quinolin-2-Ones”, Polycyclic Aromatic Compounds, Vol.43, Issue.2, pp.1-8, 2022.
  [3] N.D. Parmar, “Design, Synthesis, Characterization and Biological evaluation of (4-(7-chloroquinolin-4-yl) piperazin-1-yl)(substitutedphenyl) methanones as antimicrobial agents”. World Scientific News, Vol.122, pp.193-205, 2019.
  [4] J.H. Lange, P.C Verveer, S.J. Osnabrug, G.M. Visser, “Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions”, Tetrahedron Letters,.Vol.42, Issue., pp.1367-1369, 2001.
  [5] D.O. Bates, T.G. Cui, J.M. Doughty, “VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma”,. Cancer research, Vol.62, Issue.14, pp.4123-4131, 2002.
  [6] Hennequin, L.F., et al., “Design and structure? activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors”, Journal of medicinal chemistry, Vol.42, Issue.26, pp.5369-5389, 1999.
  [7] V. Caprio, “A novel inhibitor of human telomerase derived from 10H-indolo [3, 2-b] quinoline. Bioorganic & medicinal chemistry letters, Vol.10, Issue.18, pp.2063-2066, 2000.
  [8] L.J. Guo, C.X. Wei, J.H. Jia, L.M. Zhao, Z.S. Quan “Design and synthesis of 5-alkoxy-[1, 2, 4] triazolo [4, 3-a] quinoline derivatives with anticonvulsant activity”, European journal of medicinal chemistry, Vol.44, Issue.3, pp.954-958, 2009.
  [9] Y. Shivaraj, “Design, synthesis and antibacterial activity studies of novel quinolinecarboxamide derivatives”, Journal of the Korean Chemical Society, Vol.57, Issue.2, pp.241-245, 2013.
  [10] M.V. De Souza, K.C. Pais, C.R. Kaiser, M.A. Peralta, M.L.Ferreira, and M.C Lourenco, “Synthesis and in vitro antitubercular activity of a series of quinoline derivatives”, Bioorganic & medicinal chemistry, Vol.17, Issue.4, pp. 1474-1480, 2009.
  [11] S.S. Dave, A.M. Rahatgaonkar, “Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives”, Arabian Journal of Chemistry, Vol.9: pp.S451-S456, 2016.
  [12] F. Clemence, “4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities”, Journal of medicinal chemistry, Vol.31, Issue.7, pp.1453-1462, 1988.
  [13] S.R. Pattan, C.S.Suresh, V.V.K. Reddy, “Synthesis and antidiabetic activity of 2-amino [5`(4-sulphonylbenzylidine)-2, 4-thiazolidinedione]-7-chloro-6-fluorobenzothiazole”, Indian Journal of Chemistry -Section B, Vol.44, Issue.11,pp.2404-2408, 2005.
  [14] A. Prajapati, V.P. Modi, “Synthesis and biological evaluation of some substituted amino thiazole derivatives”, Journal of the Chilean Chemical Society, Vol.55, Issue.2, pp.240-243, 2010.
  [15] T.K., Spencer, G.I. Georg, J. Aube, “A convenient preparation of 2?[15N]?amino?4, 6?dimethoxypyrimidine”, Journal of Labelled Compounds and Radiopharmaceuticals, Vol.28, Issue.4, pp.433-436, 1990.
  [16] G. Wells, T.D. Bradshaw, M.F.G. Stevens, “Antitumourbenzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives”, Bioorganic & medicinal chemistry letters,. Vol.10, Issue.5, pp.513-515, 2000.
  [17] S. Rollas, S. GunizKuçukguzel, “Biological activities of hydrazone derivatives”, Molecules, Vol.12, Issue.8, 12(8), pp. 1910-1939, 2007.
  [18] A.A. Chavan, N.R. Pai, Synthesis and antimicrobial screening of 5-arylidene-2-imino-4-thiazolidinones. Arkivoc, Vol.16, pp.148-155, 2007.
  [19] Eicher and S. Hauptmann, The Chemistry of Heterocycles. Wiley VCH. 2003.
  [20] B.S. Dawane, S.G. Konda, V. Kamble, S. Chohan, “Multicomponent one-pot synthesis of substituted Hantzschthiazole derivatives under solvent free conditions”, E-Journal of Chemistry, Vol.6(S1): pp.S358-S362, 2009.
  [21] J. Vijaya, “Synthesis, characterization and anthelmintic activity (perituma-posthuma) of fluoro substituted benzothiazole for biological and pharmacological screening”, International Journal of Pharma and Bio Sciences, Vol.1, Issue.3, 2010.
  [22] K.S. Kim, S.K. David, K.R. Webster, “Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities”, Journal of medicinal chemistry,.45(18), pp.3905-3927, 2002.
  [23] G Luo, “Development of integrase inhibitors of quinolone acid derivatives for treatment of AIDS: an overview”,Mini Reviews in Medicinal Chemistry, Vol.10, Issue.11, pp.1046-1057, 2010.
  [24] Z. Xu, X.F. Song,Y.Q. Hu, “Azide-alkyne cycloaddition towards 1H-1, 2, 3-triazole-tethered gatifloxacin and isatin conjugates: design, synthesis and in vitro anti-mycobacterial evaluation”. European Journal of Medicinal Chemistry, Vol.138, pp.66-71, 2017.
  [25] Y.L. Fan, “Antiplasmodial and antimalarial activities of quinolone derivatives: an overview”. European Journal of Medicinal Chemistry, Vol.146, pp.1-14,2018.
  [26] C Sharma, “Insight view on possible role of fluoroquinolones in cancer therapy. Current topics in medicinal chemistry”, Vol.13, Issue.16, pp.2076-2096, 2013.
  [27] V. Sharma, R. Das D.K. Mehta “Recent insight into the biological activities and SAR of quinolone derivatives as multifunctional scaffold”,. Bioorganic & Medicinal Chemistry, Vol.59, pp.116674, 2022.

  Citation
  Fahad T. Saleh, Abdul Ahad, Anis Ahmed, Syed Ummul Khair Asema, "One-Pot Three Component Synthesis of some 8-Benzeloxy-5-{2-[N-(2-Chloro-Quinolin-3yl -Methelene)-Hydrazino]-Thiazole-4-yl}c-1H-Quinoline 2-Ones," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.29-32, 2024

• Open Access   Article

  One Pot Multicomponent Synthesis, Characterization of Pyranopyrazole Compounds with Novel Catalysed Using Pyruvic Acid

  Vishal Naiknaware, Abdul Ahad, Mazahar Farooqui, Syed Abed

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.33-35, Oct-2024

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  Abstract
  Owing to the importance of pyranopyrazole supports, several methods for their synthesis were developed. The previous intelligences on the synthesis of pyranopyrazole derivatives smarted many disadvantages which included struggle in the workup, longer reaction time, and high cost of catalyst and use of organic solvents. The present article reports the use of easily available pyruvic acid as a catalyst for multicomponent one pot synthesis using ethyl acetoacetate, malonic nitrite, sub. Aromatic aldehyde and hydrazine hydrate to synthesised pyranopyrazole derivatives. These compounds characterized by physical constant, IR spectra, 1H NMR spectra, were also studied. The presentation in the synthesis of pyranopyrazole derivatives was recognized. The present technique of synthesis of pyranopyrazole derivatives followed a simple technique and easy workup practice. The catalyst used in this reaction was easily available and gave good yield with less time.

  Key-Words / Index Term
  Pyranopyrazole compounds, One Pot Multicomponent, Malonic nitrile, Pyruvic acid

  References
  [1] A.E. Rashid, A.H. Shamroukh, M.I. Hegab, H.M. Awad, Acta Chim. Slov. 52, pp. 429–434, 2005.
  [2] A.E. Rashid, M.I. Hegab, R.E. Abdel-Megeid, J.A. Micky, M. E Farouk, A. Megeid, Bioorg. Med. Chem. 16 pp. 7102–7106, 2008.
  [3] M.A. Zolfigol, M. Tavasoli, A.R. Moosavi-Zare, P. Moosavi, H.G. Kruger, M. Shiri, V. Khakyzadeh, RSC Adv. 3, pp. 25681–25685, 2013.
  [4] S.U. Tekale, S.S. Kauthale, K.M. Jadhav, R.P. Pawar, J. Chem. pp.1–9, 2013.
  [5] A.M. El-Agrody, A.M. Fouda, A.A. Al-Dies, Med. Chem. Res. 23 pp. 3187–3199, 2014.
  [6] H.S. Chung, Y. Kim, S.J. Oh, H. Kim, S.I. Choi, Y. Zhang, J.H. Jeong, H. Bae, Bioorg. Med. Chem. 21 pp. 6359–6365, 2013.
  [7] F.Z. Macaw, N.S. Suman, S.I. Pogrebnoy, L.P. Login, A.N. Barba, Chem. Nat. Compd. 50 pp. 103–108, 2014.
  [8] Y.H. Zhang, P.Y. Gu, J.B. Zhou, Y.J. Xu, W. Liu, Q.F. Gu, D.Y. Chen, N.J. Li, Q.F. Xu, J.M. Lu, J. Mater. Chem. C 2 pp. 2082–2088, 2014.
  [9] G. Avudaiappan, T.J. Unnimaya, P. Asha, V. Unnikrishnan, K. Sreekumar, J. Heterocycl. Chem. 57 pp.197–209, 2020.
  [10] X. Li, A. Zhao, L. Moa, Z. Zhang, RSC Adv. 4 , pp.51580–51588, 2014.
  [11] M.M. Heravi, F. Mousavizadeh, N. Ghobadi, M. Tajbakhsh, Tetrahedron Lett. 55 pp. 1226–1228, 2014.
  [12] M. Behrooz, S.S. Ashrafi, RSC Adv. 81 pp. 42873–42891, 2014.
  [13] N.J. Parmar, H.A. Barad, B.R. Pansuriya, N.P. Talpada, RSC Adv. 3, pp. 8064–8070, 2013.
  [14] M.M. Mousavizadeh, F. Ghobadi, N. Tajbakhsh, Tetrahedron Lett. 55, pp. 1226–1228, 2014.
  [15] M.M. Heravi, M. Daraie, Molecules 21, pp. 441–453, 2016.
  [16] S. Alavinia, R. Ghorbani-Vaghei, New J. Chem. 44, pp. 13062–13073, 2020.
  [17] S. Alavinia, R. Ghorbani-Vaghei, RSC Adv. 11 pp. 29728–29740, 2021.
  [18] S. Alavinia, R. Ghorbani-Vaghei, J. Rakhtshah, J, S. Yousefi, A. Iman, Arabian, Appl. Organomet. Chem. 34, e5449, 2020.
  [19] A. Rahimi, S. Alavinia, R. Ghorbani-Vaghei, J. Porous Mater.11,pp.29728–29740,2021, https://doi.org/10.1007/s10934-021-01104-1.
  [20] J. Babamoradi, R. Ghorbani-Vaghei, S. Alavinia, RSC Adv. 11 pp. 19147–19157, 2021.
  [21] F.H. Dastjerdi, R. Ghorbani-Vaghei, S. Alavinia, Catal. Lett. 150 pp. 3514–3522, 2020.
  [22] G. Imperato, E. Eibler, J. Niedermaier, B. Konig, Chem.Commun. pp. 1170–1172, 2005.
  [23] G. Imperato, S. Hoger, D. Lenoir, B. Koenig, Green Chem. 8, pp. 1051–1055, 2006.
  [24] M. Petkovic, K.R. Seddon, L.P.N. Rebelo, C. Silva Pereira, Chem. Soc. Rev. 40 pp.1383–1403,2011.
  [25] A.P. Abbott, G. Capper, D.L. Davies, R.K. Rasheed, V. Tambyrajah, Chem. Commun. 7, pp. 70–71, 2003.

  Citation
  Vishal Naiknaware, Abdul Ahad, Mazahar Farooqui, Syed Abed, "One Pot Multicomponent Synthesis, Characterization of Pyranopyrazole Compounds with Novel Catalysed Using Pyruvic Acid," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.33-35, 2024

• Open Access   Article

  Preparation of Beta-Diketone Complex under Potentiometric Study with Fe (II) and Co (II) Transition Metal Ions

  Ashok N. Nagargoje

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.36-40, Oct-2024

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  Abstract
  Potentiometric study of ?–diketone complexes of iron, cobalt was carried out in aqueous media by titrating with standard NaOH solution. The complexes formation between Fe(II) and Co(II) metal ions and 1-(5-methoxythiophen-2-yl)-3-(2,4- dihydroxyphenyl)propane-1,3-dione (L) have been studied at 0.1 M ionic Strength at room temperature. It is observed that iron, cobalt, nickel and copper metal ions formed 1:1 and 1:2 complexes with ligands (L). The obtained data were used to compare the values of pH and metal-ligand stability constants.

  Key-Words / Index Term
  Potentiometric Study, ?–Diketone, Metal ions, pH and Stability Constant

  References
  [1] Cullen W. R., Wickenheiser E. B., Rhodium(I) complexes of ?-diketonates and related ligands as hydrosilylation catalysts, J. Organomet. Chem., 370, 141, 1989.
  [2] Lewis F. D., Miller A. M., Salvi D. G., Spectroscopy and photochemistry of Nickel(II), Palladium(II), and Platinum(II) ?-diketonates, Inorg. Chem., 34, 3173, 1995.
  [3] Haltiwanger C., Wenzel T. J., Williams E. J., Seivers R. E., Studies of metalchelates with the novel ligand 2,2,7-trimethyl-3,5-octanedione,Polyhedron , 4(3), 369, 1985.
  [4] Aho P., Backstrom R., Honkanen E., Linden I., Nissien E., Pohto P., nr 163044B1, PL Patent, 1994.
  [5] Miyamato M, Murata T., Yokotani H., nr 3708504, US Patent, 1973.
  [6] Aho P., Backstrom R., Koponen A., Linden T., Lonnberg K., Lotta T.,Pippuri A., Pohto P., nr 745338, AU Patent, 2002.
  [7] Odunola O., Woods J., Synthesis, Electronic and Magnetic properties of some 3-substituted-2,4-pentanedioneato oxovanadium(IV) complexes and their methylpyridine adducts, Synth. React. Inorg.Met. Org. Chem., 31(7),1297, 2001.
  [8] Anderson R. A., Kiefer R. L., Kim M., Thiebeault S. A., Modified polymeric materials for durability in the atomic oxygen space environment[J]. Nucl.Instr.And Meth. Phys. Res.,B208,300, 2003.
  [9] Schubert U., Silica-based and transition metal-based inorganic-organic hybrid materials-a comparison. J. Sol-Gel Sci. Techn.,26,47, 2003.
  [10] Meshkowa S. B., The dependence of the luminescence intensity of lanthanide complexes with ?-diketone on the ligand form. Journal of Fluorescence, 10(4),333, 2000.
  [11] Pietraszuk C., Staniszewski B., Witt K., Urbaniak W., Polskiezg?oszeniepatentowe P-393338, 2010.
  [12] Urbaniak W., nr 188732, Patent RP, 2004..
  [13] Staniszewski B., Urbaniak W., A simple and efficient synthesis of 3-substituted derivatives of pentane-2, 4-dione, Chem. Papers,63(2),212, 2009.
  [14] Irving H. M. and Rossotti H.S., J. Chem. Soc. 2, 904, 1954.

  Citation
  Ashok N. Nagargoje, "Preparation of Beta-Diketone Complex under Potentiometric Study with Fe (II) and Co (II) Transition Metal Ions," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.36-40, 2024

• Open Access   Article

  pH Metric Study of Schiff Base Metal Complexes of Nd(III)in Mixed Solvent Media

  Hansaraj Joshi, Rajpal Jadhav, RameshWare, Shailendrasingh Thakur

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.41-45, Oct-2024

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  Abstract
  Series of seven Schiff bases 4-hydroxy-3-(1-((5-substitutedphenyl)-1,3,4-thiadiazol-2-yl)imino)ethyl)-2H-chromen-2-one were synthesized by reported method. The proton-ligand and metal-ligand stability constants of these novel Schiff bases with lanthanide metal ion Nd (III) ions using a pH metric titration technique in 80% (v/v) ethanol-water mixture at three different temperatures 298K, 308Kand318K at an ionic strength of 0.1M NaClO4 were determined. The Calvin-Bjerrum method as modified by Irving-Rossotti has been employed to determine metal-ligand stability constant logK values. The thermodynamic parameters such as, Gibb’s free energy change, entropy change and enthalpy change associated with the complexation reactions were calculated.

  Key-Words / Index Term
  Stability constant, transition metal ion, Schiff bases, pH metric titration, thermodynamic parameter etc

  References
  [1] Hansaraj Joshi, Rajpal Jadhav, Gopal Dhond, Ramesh Ware, Shailendrasingh Thakur, “Complexation of Gadolinium with novel Schiff bases: Thermodynamic Study” Int. J. Scientific Research in Chemistry, Vol.9, Issue.7, pp.70-75, 2024.
  [2] Hansaraj Joshi, Rajpal Jadhav, Mazahar Farooqui, Shailendrasingh Thakur, “Thermodynamics study of formation of zinc complexes carrying novel Schiff bases in mixed solvent media.” J.Adv.Applied Sci, Tech., Vol.8, Issue.1, pp.91-96, 2022.
  [3] Jadhav R. L., Joshi H. U., Dr. S. B. Ubale, “Synthesis, characterization and biological activities of some novel Schiff bases derived from 3-acetyl-4-hydroxy-2H-chromen-2-one and 2-amino 5-(4-halosubstituted phynyl)-1-3-4-thiadiazole” Int. J. Ana. Exp. Modal Analysis, Vol. XIII, Issue XI, pp.452-464, 2021.
  [4] Jadhav R. L., Joshi H. U., Ubale S. B., “Synthesis, characterization and biological activities of some novel Schiff bases derived from 3-acetyl-4-hydroxy-2H-chromen-2-one and 5-(4-substituted phenyl)-1,3,4-thiadiazol-2-amine,” J. Interdisc. Cycle Res., Vol. XIII, Issue X, pp.414-424, 2021.
  [5] Hansaraj U. Joshi, Rajpal L. Jadhav, Mazahar N. Farooqui, Shailendrasingh V. Thakur, “Complexation of La(III) metal ion with novel schiff bases: Thermodynamic Study.”J. Advanced Scientific Research, Vol. 12, Issue 2, pp.133-136, 2021.
  [6] Hansaraj Joshi, RajpalJadhav, MazaharFarooqui, Shailendrasingh Thakur, “Thermodynamics of the formation of divalent Copper complexes carrying novel Schiff bases in mixed solvent media.” J. Interdisc. Cycle Res., Vol. 13, Issue 04, pp.53-61, 2021.
  [7] Hansaraj Joshi, Rajpal Jadhav, Mazahar Farooqui, Shailendrasingh Thakur, “Studies of complexation of trivalentrare earth metal ion Cerium with novel Schiff bases: Thermodynamic Aspect.”Int. J. Ana. Exp. Modal Analysis, Vol.13, Issue.4, pp.74-80, 2021.
  [8] Hansaraj Joshi, M.A. Sakhare, S.D.Naikwade and Shailendrasingh Thakur, “Study of complexation of divalent transition and trivalent Lanthanide metal ions with Schiff base 2-hydroxy-5-bromo acetophenone-n-(2-chloro-5-nitrophenyl) imine: Thermodynamic aspect.” J. Global Res, Vol.5, Issue.2, pp.87-89, 2019.
  [9] Shailendrasingh Thakur, Sahebrao Naikwade, Mazahar Farooqui “Thermodynamics of the formation trivalent Lanthanide complexes carrying Adenosine drug in mixed solvent media.” Int. J. Chem. Stud., Vol.1, Issue.3, pp.88-92, 2013.
  [10] Shailendrasingh Virendrasingh Thakur, Mazahar Farooqui, M.A. Sakhare, S.D. Naikwade,“Thermodynamic studies of Oxytetracycline with some transition and rare earth metal ions in mixed solvent media.” American Int. J. Res. Formal, Appl.& Nat. Sci., Vol.3, Issue.1, pp.123-127, 2013.
  [11] Shailendrasingh Thakur, Mazahar Farooqui, Sahebrao Naikwade “Thermodynamics of the complexation of Imipramine Hydrochloride drug with Lanthanide.” Int. J. Emer. Tech. Comp. and Appl. Sci., Vol.4, Issue.4, pp.342-346, 2013.
  [12] S. V.Thakur, Mazahar Farooqui, S.D. Naikwade “Thermodynamic studies of rare earth metal complexes with Metformin Hydrochloride drug in mixed solvent system.” J. Adv. Sci. Res., Vol.4, Issue.1, pp.31-33, 2013.
  [13] Thangjam PD, Lonibala R. “Potentiometric Studies on the Complexation reactions of N-(2,2-[1- (3- Aminophenyl)ethylidene] hydrazine-2- oxoethyl)benzamide with Ni2+, Cu2+ andCd2+ ions in aqueous dioxane and micellar media”. J. Chem. Eng.Data, Vol.55, Issue.3, pp.1166- 1172, 2010.
  [14] Sharmeli Y, Lonibala R. “Thermodynamics of the complexation of N-(Pyridin-2-ylmethylene) Isonicotinohydrazide with lighter lanthanides”. J. Chem. Eng. Data, Vol.5, Issue.4(1), pp.28-34, 2009.
  [15] El-Sherbiny MF. “Potentiometric and Thermodynamic Studies of 2-Thioxothiazolidi-4-one and its Metal Complexes”. Chem Paper Vol.59, Issue.5, pp.332-335, 2005.

  Citation
  Hansaraj Joshi, Rajpal Jadhav, RameshWare, Shailendrasingh Thakur, "pH Metric Study of Schiff Base Metal Complexes of Nd(III)in Mixed Solvent Media," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.41-45, 2024

• Open Access   Article

  Reconnoitring Sequel of KDP (Inorganic Ligand Potassium Dihydrogen Phosphate) on Characteristics of Cadmium Thiourea Acetate Crystal

  Rupali Balwant Kulkarni

  Research Paper | Journal-Paper (IJSRCS)

  Vol.11 , Issue.5 , pp.46-49, Oct-2024

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  Abstract
  Crystals with valuable nonlinear optical properties are exclusively demanded for nonlinear optical device applications. So present communication concentrates on scrutinizing the impact of additive KDP ( inorganic ligand potassium dihydrogen phosphate) on non-linear optical properties of CTA (Cadmium Thiourea Acetate) crystal. Both parent & doped crystals were grown from aqueous solution by slow evaporation solution growth technique at 35°C. In Present communication, Kurtz–Perry powder Second Harmonic Generation (SHG) test pointed the towering nonlinearity of KDP-CTA crystal than Parent CTA crystal. TONLO nature of KDP doped CTA crystal was studied via Z-scan technique. The TONLO refractive index (n2), absorption coefficient (?) and cubic susceptibility (?3) of KDP doped CTA crystal has been evaluated using the Z-scan transmittance data. The order of third order nonlinear optical parameters (TONLO) n2, ? and ?3 is recorded as 10-10 cm2/W, 10-5 cm/W, 10-4 esu respectively. Determined TONLO parameters vitalize its application for laser stabilization systems.

  Key-Words / Index Term
  Crystal growth, SHG efficiency, TONLO parameters, Transmittance, Close aperture

  References
  [1] Mohd Shakir, S.K. Kushwaha, K.K. Maurya, Manju Arora, G. Bhagavannarayana, J.Cryst. Growth 311, pp.3871–3875, 2009. DOI:10.1016/j.jcrysgro.2010.01.031
  [2] V. Ganesh, Mohd. Shkir, Rizwan Husain, Rajveer Singh, T. Bhaskar Rao, K. Kishan Rao, Optik 124, pp.6690-6695, 2013. DOI:10.1016/j.ijleo.2013.05.087
  [3] Mohd Shakir, B. Riscob, K.K. Maurya, V. Ganesh, M.A. Wahab,G. Bhagavannarayana, J. Cryst. Growth 312, pp.3171–3177, 2010. DOI:10.1016/j.jcrysgro.2010.07.061
  [4] Mohd Anis, Gajanan.G. Muley, Optics & Laser Technology 90, pp.190-196, 2017. DOI:10.1016/j.optlastec.2016.11.020
  [5] N. N. Shejwal, Mohd Anis, S.S. Hussaini, M.D. Shirsat, Int. J. Mod. Phys. B 30, pp.1650159–1650170, 2016. DOI:10.1142/S0217979216501599
  [6] N. N. Shejwal, Mohd Anis, S.S. Hussaini, M.D. Shirsat, Phys. Scr. 89, pp.125804–125810, 2014. DOI:10.1402-4896/89/12/125804
  [7] N. P. Rajesh, V. Kannan,, M. Ashok, K. Sivaji,P. Santhana Raghavan, P. Ramasamy, Journal of Crystal Growth 262, pp.561–566, 2004. DOI:10.1016/j.jcrysgro.2003.10.064
  [8] R. Geetha Kumaria, V. Ramakrishnana, M. Lydia Carolin b, J. Kumarb,Andrei Saruac, Martin Kuball Spectrochimica Acta Part A 73, pp.263–267, 2009. DOI:10.1016/j.saa.2009.02.009
  [9] V. Ganesh, T. Bhaskar Rao, K. Kishan Rao, G. Bhagavannarayana, Mohd. Shkir, Materials Chemistry and Physics 137, pp.276-281, 2012. DOI:10.1016/j.physb. 2010.10.061
  [10] S. Shahil Kirupavathya, S. Stella Marya, P. Mythili, R. Gopalakrishnan, Journal of Crystal Growth 310, pp.2555-2562, 2008. DOI:10.1016/j.jcrysgro.2008.01.020
  [11] S.S. Kirupavathy, S.S. Mary, P. Srinivasan, N. Vijayan, G. Bhagavannarayana, R. Gopalakrishnan, J. Cryst. Growth 306, pp.102-110, 2007. DOI:10.1016/j.jcrysgro.2007.03.036
  [12] J. Uma ,V.Rajendran, Inter. J. of Computer Applications 30, pp.08-10, 2011.
  [13] Mohd Anis, S. S. Hussaini, M. D. Shirsat and G. G. Muley, Materials Research Innovations 200, pp.312-316, 2016. DOI:10.1080/14328917.2015.1137693
  [14] S. M. Azhar, Mohd Anis, S.S. Hussaini, S. Kalainathan, M.D. Shirsat G. Rabbani, Optics & Laser Technology 87, pp.11-16, 2017. DOI: 10.1016/j.optlastec.2016.07.007
  [15] R. Sankar, Cryst. Res. Technol. 41, pp.919-924, 2006. DOI:10.1002/crat.200510696
  [16] Johanan Christian Prasana, Asian Journal of Chemistry 25, pp.969-971, 2013. DOI:10.14233/ajcchem.2013.13274
  [17] Mohd Anis, M.D.Shirsat, GajananMuley, S.S.Hussaini, Physica B 449, pp.61-66, 2014. DOI:10.1016/j.physb. 2014.05.007
  [18] Mohd Anis, G.G. Muley, A. Hakeem, M.D. Shirsat, S.S. Hussaini, Optical Materials 46, pp.517-521, 2015. DOI:10.1016/j.optmat.2015.04.064
  [19] Mohd. Shakir, V. Ganesh, B. Riscob, K.K. Maurya, K. Kishan Rao, M.A. Wahab, G. Bhagavannarayana, Int. J. of Pure and Appl.Physics7, pp.13-24, 2011. http://www.ripublication.com/ijpap.htm
  [20] Y.B. Rasal, R. N. Shaikh, M. D. Shirsat, S. Kalainathan, S. S. Hussaini ,Materials Research Express, 2017. DOI:10.1088/2053-1591/aa5a66
  [21] S. K. Kurtz, T.T. Perry J. Appl. Phys. 39, pp.3698-3813, 1968. DOI: 10.1063/1.1656857
  [22] Rupali B. Kulkarni, Mohd. Anis, S. S. Hussaini, M.D. Shirsat, Materials Research Express, 2018. DOI:10.1088/2053-1591/aab2f8
  [23] M. I. Baig, Mohd Anis, G.G. Muley, Optical Materials 72, 2017. DOI:10.1016/j.optmat.2017.05.042
  [24] Mohd Anis, S.P.Ramteke, M.D.Shirsat, G.G.Muley, M.I.Baig, Opt.Mater. 72, pp.590-595, 2017. DOI:10.1016/optmat.2017.07.007
  [25] Ting Bin Li, Ya Li Hu, Chun Lin Ma, Guo Fang He, Ren Gao Zhao,Guo Bing Zhen,Appl. Organometal. Chem. 25, pp.867-870, 2011. DOI:10.1002/aoc.1852
  [26] Yali Hu, Tingbin Li, Materials Chemistry and Physics, 2014. DOI:10.1016/j.matchemphys.2014.04.008
  [27] M. S. Bahae, A.A. Said, T.H. Wei, D.J. Hagan, E.W.V. Stryland IEEE J. Quant. Electron. 26, pp.760-769, 1990. DOI:10.1109/3.53394
  [28] S. P. Ramteke, Mohd Anis,M.S. Pandian, S. Kalainathan, M.I. Baig, P. Ramasamy, G.G. Muley,Optics and Laser Technology 99, pp.197-202, 2018. DOI:10.1016/j.optlastec. 2017.09.003
  [29] X. Q. Wang, Q. Ren2, J. Sun, H. L. Yang, T. B. Li, H. L. Fan, G. H. Zhang, D. Xu,J. H. Zhao,Cryst. Res.Technol. 4, pp.657-668, 2009. DOI 10.1002/crat.200900082
  [30] Vijender Singh,Praveen Aghamkar,Rajesh Kumar Malik, Appl. Phys. B, 2013. DOI 10.1007/s00340-013-5614-z
  [31] Major, J. s. Aitchison,p.w.e. smith,f. Druon,P. Georges,B. Viana, G.P. Aka, Appl. Phys. B 80, pp.199–201, 2005. DOI: 10.1007/s00340-004-1703-3
  [32] L. T. Jin , X.Q.Wang, Q.Ren, N.N.Cai , J.W.Chen , T.B.Li , X.T.Liu , L.N.Wang, G.H.Zhang,L.Y.Zhu,D.Xu, Journal of Crystal Growth 356, pp.10-16, 2012. DOI:10.1016/j.jcrysgro. 2012.07.005
  [33] Y. B. Rasal, Mohd Anis, M. D. Shirsat,S. S. Hussaini, Materials Research innovations, 2017. DOI: 10.1080/14328917.2017.1327199
  [34] N. Vijayan,G. Bhagavannarayana,S.K. Halder,S. Verma,J. Philip,R. Philip,Brijesh Rathi, Appl. Phys. A 110, pp.55–58, 2013. DOI 10.1007/s00339-012-7448-7
  [35] Mohd Anis, M.I. Baig, S.S. Hussaini, M.D. Shirsat, Mohd Shkir, H.A. Ghramh, Chin. Phys. B 27, pp.27800-27806, 2018.
  [36] S. P. Ramteke, M.I. Baig, Mohd Shkir, S. Kalainathan, M.D. Shirsat, G.G. Muley, Mohd Anis, Opt. Laser Technol. 104, pp.83-89, 2018. DOI:10.1016/j.optlastec.2018.02.018

  Citation
  Rupali Balwant Kulkarni, "Reconnoitring Sequel of KDP (Inorganic Ligand Potassium Dihydrogen Phosphate) on Characteristics of Cadmium Thiourea Acetate Crystal," International Journal of Scientific Research in Chemical Sciences, Vol.11, Issue.5, pp.46-49, 2024