In Vivo and In Vitro Antitrypanosomal Activities of Nigerian Medicinal Plants

A. Abubakar¹ , M. A. Yaro² , G. Abdu³ , F. A. Rufa’i⁴

Section:Review Paper, Product Type: Journal-Paper
Vol.6 , Issue.4 , pp.4-9, Oct-2019

Online published on Oct 31, 2019

Copyright © A. Abubakar, M. A. Yaro, G. Abdu, F. A. Rufa’i . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
African trypanosomiasis is one of the neglected tropical diseases caused by different species of trypanosomes that affect both human and livestock with devastating consequences in the continent. Clinically available chemotherapeutic drugs have been reported to be ineffective and also have severe side-effects. Plants have been used for many centuries with the purpose of feeding populations worldwide and to establish or bring back health, well-being, and the cure for several illnesses. A vast majority of people from less developed countries, including Nigeria depend on medicinal plants for the treatment of various diseases, due to the high cost of synthetic drugs. The present review reported the in vivo and in vitro antitrypanosomal activity of Nigerian medicinal plants. Almost seventy medicinal plants were reported for antitrypanosomal activity in this paper. The paper recommended that further research on other medicinal plants should be investigated for antitrypanosomal activities.

Key-Words / Index Term :
In vivo, in vitro, Extract, plants, trypanosomes

References :
[1] N. V. Pacheco, “Can the Cure for Chagas’ Disease be Found in Nature?, Natural Remedies in the Fight Against Parasites” Hanem Khater, M. Govindarajan and Giovanni Benelli, IntechOpen, 2017.
[2] F. S. E. Paul, M. F. Mahomoodally, “New Insights in Staging and Chemotherapy of African Trypanosomiasis and Possible Contribution of Medicinal Plants” The Scientific World Journal, Vol. 2012, pp. 16, 2012.
[3] V. A. Maikai, U. Abubakar, A. A. Salman, T. N. Inuwa, “Preliminary Survey of Medicinal Plants Used in Treatment of Animal Trypanosomiasis in Kaduna State, Nigeria” Ethnobotanical Leaflets, Vol. 14, pp. 319-326, 2010.
[4] M. I. Auwal, A. Mohammed, M. I. Bindawa, A. A. Babando, “Anti-trypanosomal activity of African medicinal plants: A review update” Journal of Ethnopharmacology, Vol. 154, Issue 1, pp. 26-54, 2014.
[5] S. E. Atawodi, “Comparative in vitro trypanocidal activities of petroleum ether, chloroform, methanol and aqueous extracts of some Nigerian savannah plants” African Journal of Biotechnology, Vol. 4, Issue 2, pp. 177-182, 2005.
[6] R. Brun, J. Blum, F. Chappuis, C. Burri, “Human African Trypanosomiasis” Lancet, Vol. 375, pp. 148–159, 2010.
[7] E. O. Ogbadoyi, A. O. Abdulganiy, T. Z. Adama, J. I. Okogun, “In vivo trypanocidal activity of Annona senegalensis Pers leaf extract against Trypanosoma brucei brucei” Journal of Ethnopharmacology, Vol. 112, pp. 85–89, 2007.
[8] W. N. Setzer, I. V. Ogungbe, “In-silico Investigation of Antitrypanosomal Phytochemicals from Nigerian Medicinal Plants” PLoS Negl Trop., Dis., Vol. 6, Issue 7, 2012.
[9] E. Torreele B. B. Trunz, D. Tweats, M. Kaiser, R. Brun, “Fexinidazole – A new Oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness”. PLoS Negl Trop Dis Vol. 4, 2010.
[10] T. Feyera, G. Terefe, W. Shibeshi, “Evaluation of in vivo antitrypanosomal activity of crude extracts of Artemisia abyssinica against a Trypanosoma congolense isolate” BMC Complementary and Alternative Medicine, Vol. 14, 2014.
[11] J. B. Balogun, Z. Abubakar, T. B. Ibrahim, S. U. Balogun, I. S. Sadiq, M. M. Dogara, S. I. Idoko, H. O. Owolodun, M. A. Orendu, “In Vivo Anti-Trypanosomal Potential of Methanol Root Extract of Terminalia macroptera (Guill. And Perr.) In Trypanosoma brucei brucei Infected Wistar Rat” IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS), Vol. 12, Issue I, pp. 1-6, 2017.
[12] S. E. Atawodi, D. A. Ameh, S. Ibrahim, J. N. Andrew, H. C. Nzeilibe, E. Oniyike, “Indigenous knowledge system for treatment of trypanosomiasis in Kaduna state of Nigeria” Journal of Ethnparmarmacol., Vol. 79, pp. 279-282, 2002.
[13] R. M. Esther, S. S. Jacqueline, R. Gildardo, A. M. Laurence, “Mexican Medicinal Plants as an Alternative for the Development of New Compounds against Protozoan Parasites, Natural Remedies in the Fight against Parasites” Hanem Khater, M. Govindarajan and Giovanni Benelli, IntechOpen, 2017.
[14] R. M. Kutama, S. Abdulkadir, S. A. Kwalli, G. Chiroma, “Phytochemical Compositions in Some Nigerian Medicinal Plants and Their Pharmacological Properties: A Review” Journal of Anesthesiology, Vol. 6, Issue 1, pp. 15-25, 2018.
[15] A. Mann, E. O. Ogbadoyi, “Evaluation of Medicinal Plants from Nupeland for their In vivo Antitrypanosomal Activity” American Journal of biochemistry, Vol. 2, Issue 1, pp. 1-6, 2012.
[16] A. U. Wurochekke, A. J. Nok, “In vitro anti trypanosomal activity of some medicinal plants used in the treatment of trypanosomosis in Northern Nigeria” African Journal of Biotechnology, Vol. 3, Issue 9, pp. 481-483, 2004.
[17] M. N. Shuaibu, P. T. A. Wuyep, T. Yanagi, K. Hirayama, A. Ichinose, T. Tanaka, I. Kouno, “Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides” Parasitol Res, Vol. 102, pp. 697–703, 2008.
[18] R. E. Antia, J. O. Olayemi, O. O. Aina, E. O. Ajaiyeoba, “In vitro and in vivo animal model antitrypanosomal evaluation of ten medicinal plant extracts from south west Nigeria” African Journal of Biotechnology, Vol. 8, Issue 7, pp. 1437-1440, 2009.
[19] A. H. Abu, C. N. Uchendu, R. A. Ofukwu, “In vitro anti trypanosomal activity of crude extracts of some Nigerian medicinal plants” Journal of Applied Biosciences, Vol. 21, pp. 1277 – 1282, 2009.
[20] J. O. Olukunle, M. O. Abatan, O. T. Soniran, M. I. Takeet, O. A. Idowu, F. A. Akande, K. T. Biobaku, E. B. Jacobs, “In vivo antitrypanosomal evaluation of some medicinal plant extracts from Ogun state, Nigeria” Science World Journal, Vol. 5,Issue 1, pp. 17-19, 2010.
[21] S. E. Atawodi, H. Shehu, “Antitrypanosomal Property of Some Extracts of Different Parts of Moringa oleifera, Lam” Electronic Journal of Biology, Vol. 6, Issue 1, pp. 19-23, 2010.
[22] S. E. Atawodi, T. Bulus, M. Mamman, “Bioassay Guided Fractionation and Anti-Trypanosomal Effect of Fractions and Crude Aqueous and Methanolic Extracts of Terminalia Avicennioides (Guill. & Perr.) Parts” International Journal of Biology, Vol. 3, Issue 3, 2011.
[23] A. Mann, O. R. Ifarajimi, A. T. Adewoye, C. Ukam, E. E. Udeme, I. I. Okorie, M. S. Sakpe, D. R. Ibrahim, Y. A. Yahaya, A. Y. Kabir, E. O. Ogbadoyi, “In vivo antitrypanosomal effects of some ethanomedicinal plants from Nupeland of north central Nigeria” Journal of Traditional Complement and Alternative Medicine, Vol. 8, Issue 1, pp. 15-21, 2011.
[24] E. O. Ogbadoyi, M. H. Garba, A. Y. Kabiru, A. Mann, J. I. Okogun, “Therapeutic evaluation of Acacia nilotica (Linn) stem bark extract in experimental African Trypanosomiasis” International Journal of Applied Research in Natural Products, Vol. 4, Issue 2, pp. 11–18, 2011.
[25] A. Abubakar, B. Iliyasu, F. N. Ojiegbu, A. C. Igweh, B. U. Shamaki, E. C. Dung, L. L. Domtur, J. I. Okogun, T. A. Gbodi, E. O. Ogbadoyi, “Evaluation of the antitrypanosomal activity of Cucumis metuliferus pulp extract in rabbits” Journal of Medicinal Plants Research, Vol. 5, Issue 11, pp. 2136-2142, 2011.
[26] O. O. Abiodun, O. G. Gbotosho, E. O. Ajaiyeoba, R. Brun, A. M. Oduola, “Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine” Parasitol Res, Vol. 110, pp. 521–526, 2012.
[27] M. I. Auwal, A. A. Babando, K. Meduteni, I. Yunusa, “Saponins-rich fraction of Calotropis procera leaves elicit no antitrypanosomal activity in a rat model” Asian Pacific Journal of Tropical Biomedicine, Vol. 3. Issue 7, pp. 569-572, 2013.
[28] V. O. Adelodun, C. A. Elusiyan, F. O. Olorunmola, F. B. Adewoyin, N. O. Omisore, A. O. Adepiti, J. M. Agbedahunsi, C. O. Adewunmi, “Evaluation of antitrypanosomal and anti-inflammatory activities of selected Nigerian medicinal plants in mice” Afr J Tradit Complement Altern Med. Vol. 10, Issue 6, pp. 469-476, 2013.
[29] U. A. Ismaila, N. U. Samuel, M. Aminu, A. V. Chidi, Z. U. Umar, U. A. Umar, B. M. Adewale, “In vitro antitrypanosomal activity, antioxidant property and phytochemical constituents of aqueous extracts of nine Nigerian medicinal plants” Asian Pacific Journal of Tropical Disease, Vol. 4, Issue 5, pp. 348-355, 2014.
[30] C. S. Onotu, U. B. Musa, O. G. C. Ezebuiro, T. Tese, M. U. Ogar, S. S. Shaida, K. Y. Baraya, J. E. Benjamin, “In Vivo Anti-Trypanosomal Activity of Ethanolic Leaf Extract of Carissa Spinarum (Wild Karanda) in Mice Infected with Trypanosoma Brucei Brucei Spp.” Advances in Life Science and Technology, Vol. 25, pp. 8-13, 2014.
[31] U. E. Igbo, J. O. Igoli, S. O. Onyiriuka, A. E. Ejele, C. E. Ogukwe, A. A. Ayuk, G. N. Elemo, A. I. Gray, “Antitrypanosomal and Antioxidant Activities of Moringa Oleifera Lam Leaf Extracts” Journal of Pharmaceutical, Chemical and Biological Sciences, Vol. 3, Issue 1, pp. 17-23, 2015.
[32] D. A. Omoboyowa, O. T. Soniran, A. O. Aja, F. O. Chukwu-Oko, “In-vivo and In-vitro Anti-Trypanosomal Activity of Tithonia diversifolia Ethanol Leaf Extract on Typanosoma brucei brucei Infected Rats” Acta Parasitologica Globalis Vol. 7, Issue 2, pp. 87-93, 2016.
[33] P. Shaba, S. Dey, N.P. Kurade, R.K. Singh, “Trypanocidal Activity of Methanolic Extracts (50 and 100%) of Emblica officinalis (Phyllanthus emblica Linn) Dried Fruits against Trypanosoma evansi” Advances in Pharmacognosy and Phytomedicine, Vol. 2, Issue 1, pp. 1-8, 2016.
[34] P. Shaba, N. N. Pandey, O. P. Sharma, J. R. Rao, R. K. Singh, “Trypanocidal potential of Camellia sinensis (Green Tea)” Greener Journal of Agricultural Sciences, Vol. 1, Issue 1, pp. 055-061, 2011.
[35] S. Assefa, “Potential anti-trypanosomal plants against African animal trypanosmiasis” Journal of Pharmacognosy and Phytochemistry, Vol. 6, Issue 5, 77-85, 2017.
[36] M. Zubairu, M. S. Abdullahi, “In Vitro Anti Trypanosomal Activity of Crude and Fractionated Ethanolic Extracts of Chrysophyllum albidum (African Star Apple) Leaves” International Journal of Science and Research, Vol. 6, Issue 4, pp. 2053-2055, 2017.
[37] S. O. Oguntoye, O. M. Bello, P. S. Fasinu, I. A. Khan, Z. Ali, S. I. Khan, L. A. Usman, “Evaluation of Selected Nigerian Medicinal Plants for in vitro Antiprotozoal Activity” The Natural Products Journal, Vol. 8, Issue 3, 2018.
[38] L. Bashir, O. K. Shittu, S. Sani, M. B. Busari, K. A. Adeniyi, “African Natural Products with Potential Anti-trypanosomal Properties: A Review” International Journal of Biochemistry Research and Review, Vol. 7, Issue 2, pp. 45-79, 2015.