Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Bases of 1-Amino-7-hydroxy-2-methylquinoline-4(1H)-one

S.K. Vishwakarma¹ , A. Pradhan²

1. Department of Chemistry, S .N. Govt. G.P.G. College, Bhopal (Madhya Pradesh), India.
2. Department of Chemistry, S .N. Govt. G.P.G. College, Bhopal (Madhya Pradesh), India.

Section:Research Paper, Product Type: Journal-Paper
Vol.7 , Issue.2 , pp.18-22, Apr-2020

Online published on Apr 30, 2020

Copyright © S.K. Vishwakarma, A. Pradhan . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
We have synthesized eight Schiff bases of 1-amino-7-hydroxy-2-methylquinolin-4(1H)-one named as Q4AA-Q4AH by refluxing (Q4A) with substituted aromatic aldehydes in ethanol for 5-7 hrs. The final test compounds has purified and characterized by IR, 1HNMR and Mass Spectral studies. M.P. of these compounds was confirmed by open capillary method instrument chemline Cl 725. They have evaluated for antibacterial activity. Compounds were active against Klebsiella pneumonia and Enterococcus faecalis. Test compounds, such as Q4AD, Q4AE and Q4AF showed moderate activity against gram positive micro-organism while Q4AG and Q4AF showed activity against gram negatives organism lower than standard ciprofloxacin. Their antimicrobial activity was evaluated by wells diffusion method.

Key-Words / Index Term :
Resacetophenone, 4-quinolone, acylchloride, pyridine, Schiff’s bases, well diffusion

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