Synthesis, Antimicrobial and Antioxidant Activity of Heterocyclic Schiff Bases and Their Metal Complexes

J.N. Borase¹ , R.G. Mahale² , S.S. Rajput³

Section:Research Paper, Product Type: Journal-Paper
Vol.7 , Issue.4 , pp.5-12, Aug-2020

Online published on Aug 31, 2020

Copyright © J.N. Borase, R.G. Mahale, S.S. Rajput . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

View this paper at   Google Scholar | DPI Digital Library

XML View     PDF Download

How to Cite this Paper

Abstract :
Schiff bases Transition metal complexes have remained an important and popular area of research due to their versatility, simple synthesis. The current article focus on the synthesis, characterization and biological evaluation of synthesized transition metal complexes from heterocyclic Schiff base ligand. All newly synthesized Transition metals complexes of Fe (III), Co (III), Cu (II), and Ni (II) were screening for their elemental analysis, FT-IR, ESR, and Magnetic Susceptibility. Thermal behavior of the complexes were examined for their kinetic parameters are Energy of activation (Ea), Free energy change (∆G), Entropy change (∆S), Order of reaction (n) these are analyzed by Freeman Carroll method. The X- Band of ESR spectra indicates square planer geometry of Cu(II) and Ni(II) complexes and Fe(III) and Co(III) represents octahedral geometry. The screening results of antibacterial and antioxidant activity complex exhibits good antimicrobial and excellent antioxidant activity

Key-Words / Index Term :
Schiff base, Metal complexes, FT-IR, Thermal analysis, ESR, Antimicrobial, Antioxidant, Magnetic susceptibility

References :
[1]. K.Arora, K.P.Sharma, ?Studies on high-coordination complex of dioxouranium (VI) with a Schiff base? Synthesis and reactivity in Inorganic and metal-Organic chemistry, Vol-32, Issue 5, PP 913-922, 2002.
[2]. C.Celik, M.Tumer, S.Serin, ?Complex of tetradentate Schiff base ligand with divalent transition metal? Synthesis and reactivity in Inorganic and Metal- Organic chemistry,Vol- 32,Issue10, PP 1839-1854,2002.
[3]. R.Ramesh, M.Sivagamsundri, ?Syntheis, Spectral and antifungal activity of Ru (II) Mixed ligand complexes? Synthesis and reactivity in Inorganic and Metal- Organic chemistry,Vol-33, Issue 5, PP 899-910,2003.
[4]. R.C.Maurya, R.Verma, T.Singh, ?Synthesis, magnetic mono and binuclear dioxomolybdenum (VI) complexes with chelating hydrazones and furfural or Thiopene-2-aldehyde? Synthesis and reactivity in Inorganic and Metal- Organic chemistry,Vol-33, Issue 2, PP 309-325, 2003.
[5]. P.J.Dardlier, R.E.Homlin, ?Synthesis, DNA-binding and cleavage studies of macrocyclic copper (II) complex? J.K.Barton Science. Vol-274, 1465, 1997.
[6]. A.S.Sitalani, E.C.Long, A.M.Pyle, ?DNA photocleavage by phenanthrenequinone diimine complexes of rhodium (III)? Journal of American chemical Society. Vol-114, Issue 7, PP 2303-2312, 1992.
[7]. J.Tisato, F.Refosco, F.Bandoli, ?Synthesis and characterization of square planer nickel (II) complexes with O, N, O, donor tridentate pendant Schiff base? journal of American chemical society. Rev.135, Vol-325, 1994.
[8]. D.Worku, M.Negussie, V.J.T.Raju,?Synthesis and study of Schiff base ligand? Bulletin of the chemical society of Ethiopia. Vol-17, Issue 30, 2002.
[9]. M.Fujita, Doguro, M.Miyazawa, H.Oka, K.Yamaguchi and K.Ogura, Nature, Vol-378, 469, 1995.
[10]. P, Paul. ?Ruhtenium, Osmium and Rhodium complexes of polypyridyl ligand? Journal of chemical science. Vol-114, Issue 4, PP 443-449, 2002.
[11]. L.A.Paquette, W.a.Benjamin, ?Study of Schiff base compound and its derivatives? Principles of Modern Heterocyclic Chemistry. Vol-318, (1968).
[12]. N.H. Lee, j.C.Byun, J.S.Baik, ? Development of Mn (II) Schiff base complexes for the catalyst of olefin oxygenation to alcohol in the presence of NaBH4? Bulletin of Korian chemical science. Vol-23, Issue 10, PP 1365-1366, 2002.
[13]. S.A.Patel, S.Sinha, A.N.Mishra, R.N.Ram, ?olifine epoxidation catalyzed by Mn (II) Schiff base complex in Heterogeneous-Homogeneous system. Journal of molecular catalysis A: Vol-192, Issue 1-2, PP 53-61, 2003.
[14]. O.Pouralimardan, A.C.Chamayou, C.Janiak, Hosseini Hasasan, ?Hydrazones Schiff base-mangnese (II) complexes? Inorganica chimica Acta, Vol-360, Issue 5, PP 1599-1608, 2007.
[15]. A.R.Moosavi-Zare, H.Goudarziafshar, Khadijeha Saki,?Synthesis of pyranopyrazoles using nano-Fe-[Phenylsalicylaldiminemethylpyranopyrazole] Cl2 as a new Schiff base complex and catalyst? Applied Organomettlaic chemistry.Vol-32, Issue 1, PP 3698-;1-8, 2017.
[16]. Beyazit, D.Cakmak, C.Demetgul, ?Synthesis of salen-type of Schiff base metal complexes? Journal of Tetrahydron, Vol-73, PP 2774-2779, 2017.
[17]. A.S.Abu-Surrah, k.A.Abu-safieh, M bearing pyrazole based Schiff base ligand? Europian Journal of medicinal chemistry. Vol-5, Issue 2, PP 471-475, 2010.
[18]. J.Joseph, M.S.Muneera,? Synthesis, spectroscopic and thermal studies of Fe (III) and Vo (IV) complexes? Der Pharma chimica.Vol-12, Issue 45-60, 2016.
[19]. K.R.Surati, P.A.Sathe,?Schiff base pyrazolone complex of iron (III)? Medicinal chemical Research. Vol-25, Issue 12, PP 2742-2751, 2016.
[20]. J.N.Borase, R.G.Mahale, S.S.Rajput,?Synthesis characterization of novel class of heterocyclic Schiff base? European Journal of Biomedicine Pharmaceutical Science. Vol-4, Issue 10, PP 842-845, 2017.
[21]. C.J.Ballhausen, ?Introduction to ligand field theory? McGraw-Hill, New York, 1962.
[22]. S. Srinivasan, P. Athapan, G. Rajgopal, ?Synthesis, spectral and redox properties of metal complexes of macrocyclic tetraaza chiral Schiff base? Transition metal chemistry, Vol-26, PP 588-593, 2001.
[23]. R.S.Bendre, S.K.Tadvi, M. Patil,?Synthesis,crystal structure and biological activities of transition metal complexes of a salen-type ligand? Transition metal chemistry. Vol-43, Issue 1, PP 4863-4879, 2017.
[24]. R. M. Kadam, M.D. Sastry, M.K Bhinde, S.A.Chavan, J.V.Yakhmi, and O. Khan ?EPR studied on (NBu4)2CO2[Cu(opbu)] 3-S? Chemical physics letters. Vol-357, Issue (5-6), PP 457-463, 1997.
[25]. M.Base, K. Ohta, Y. Babu and M.D. Sastry?Synthesis, spectral characterization of Schiff base transition metal complexes? Chemistry of physics letters, PP 324-330, 2000.
[26]. R. K Ray and G.B. Kauffman.?EPR spectra and covalency of bis (amidinourea) copper (II)? Inorganica chimica Acta. Vol-173, Issue 2, PP 207-214, 1990.
[27]. K.Jeyasubramanian, S. A. Samath, S. Thambidurai, R.Murugesan and S.K. Ramalingam?Electronic spectra of some transition metal complexes: Derivatives of Dq and B? Transition metal chemistry. Vol-20, Issue 76, 1996.
[28]. B.B. Raj, M.P. Kurup, E. Suresh,?Synthesis, spectral characterization and crystal structure of N-2-Hydroxy-4-Methoxy benzaldehyde-N-4-nitro benzoyl hydrazone and its square planer Cu (II) complex? Spectrochemica Acta part A: Molecular Bimolecular spectroscopy, Vol-71, Issue 4, PP 1253-1260, 2008.
[29]. N.Raman, Y.P.Raja, A. Kulandaisamy, ?Synthesis and characterization of Cu (II), Ni(II), Mn(II),Zn(II) and VO(II) Schiff base complexes derived from orthophenylenediamine and acetoactanilide? Journal of Chemical science. Vol-113, PP 183-189, 2001.
[30]. B. Hathaway, D.E.Billing, ?The electronic properties and stereochemistry of mono-nuclear complex of the copper (II)? Coordination chemistry Reviews, Vol-5, PP 143-207, 1970.
[31]. A. M. F. Benial, V.Ramakrishna and Murugesan,?Synthesis, Spectral characterization of Schiff base transition metal complex?Spectrochimica.Acta: part: A. Vol-56, 2775, 2000.
[32]. N.Raman, S Ravichandran, ?Synthesis and characterization of a new Schiff base? Inorganic Metal-organic and Nano metal chemistry. Vol-35, Issue 6, PP 439-444, 2005.
[33]. F. Al-Salman , A. Ali Redha , Zahraa Al-Zaimoor, ?Inorganic Analysis and Antioxidant Activity of Shilajit? International Journal of Scientific Research in Chemical Sciences Vol.7, 3, PP.05-10, 2020.