Evaluation of Renoprotective Potential of Plantain (Musa parasidiaca) Stem Juice on Rat Model Diabetes

S.O. Oguche¹

Section:Research Paper, Product Type: Journal-Paper
Vol.8 , Issue.5 , pp.10-14, Oct-2021

Online published on Oct 31, 2021

Copyright © S.O. Oguche . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
The prevalence of diabetes mellitus in the world is increasing. Hyperglycemia in diabetes mellitus can increase the risk of complications in various organs, one of which is chronic renal failure because symptoms of type 2 diabetes, unlike type 1 diabetes, do not occur, the screening methods for identifying kidney involvement is very important. In chronic renal failure, a decline in kidney function is chronic, resulting in increase of the levels of blood urea nitrogen (BUN) and creatinine in the blood. A level of BUN and creatinine serum is use as a parameter of kidney function tests. Plant-derived medicinal products have attracted the attention of scientists around the world for many years due to their minimum side effects and positive effects on human health hence the choice of plant used in the present study. 35 healthy Albino (Wister strain) were obtained and grouped into seven. The results obtained from sub-diabetic and diabetic rats both treated with 250mg/kg/bw and 500mg/kg/bw respectively when compared with diabetic control, plantain stem juice shows a lowering effect on the blood creatinine and BUN concentration. The effect of the stem juice of Musa paradisiaca suggests that it can be useful in controlling creatinine and BUN concentration in diabetics and will serve as a better alternative to synthetic drugs.

Key-Words / Index Term :
Diabetes; BUN; Creatinine; Alloxan; Musa parasidiaca; Rats

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