Hepatitis B Virus among Blood Donors: A Four Year Retrospective Study of a Primary Health Care, Jigawa State

S.O. Oguche¹

Section:Research Paper, Product Type: Journal-Paper
Vol.8 , Issue.6 , pp.1-5, Dec-2021

Online published on Dec 31, 2021

Copyright © S.O. Oguche . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Blood transfusion is a life-saving intervention that has an essential role in patient management within health care systems. Unfortunately, many cases of hepatitis B virus (HBV) infections in adult populations were found to be associated with blood transfusions, since HBV is infective through blood and body-fluid, including vertical transmission. Today, hepatitis B virus is among the greatest threats to blood safety for the recipient. This study aimed to determine the seroprevalence of HBV infections among blood donors over a period of 4 years at Amaryawa Model Primary Health Care (AMPHC), Jigawa State, Nigeria. The recorded blood donors? history and laboratory tests were reviewed by data collectors analyzed with Statistical Package for the Social Sciences version 20 software. A p-value of less than 0.005 was considered statistically significant. A total of 10,416 consecutive blood donors were screened between January 2018 and December 2021. The seroprevalence of HBV was 15% and 11% for uneducated family and commercial donors respectively. The prevalence of HBV was significantly associated with male rural dwellers {ECD: 43(6%), UeCD: 272(11%), EFD: 47(7.5%), UeFD: 987(15%)}, blood donors within 20-60 years of age. The current study shows the prevalence of hepatitis B virus was high among study participants. A substantial percentage of the blood donors harbor HBV infections. Therefore, it is recommended to increase awareness of people (particularly on unmarried, male and rural dwellers) on modes of transmission and prevention of infection, which could help in reducing the burden of hepatitis B virus.

Key-Words / Index Term :
Hepatitis B; Blood Donor; Prevalence; Transfusion; Jigawa; Nigeria

References :
[1] E. Dahlström, E. F. Viberg, "Knowledge about Hepatitis B and Attitudes Towards Hepatitis B among Vietnamese University Students in Ho Chi Minh City", Thesis in Caring Sciences, Vietnam, pp.1-39, 2013.
[2] C.M. Weinbaum, E.E. Mast, J.W. Ward, "Recommendations for Identification and Public Health Management of Persons with Chronic Hepatitis B Virus Infection", Hepatology, Vol.49, Issue.5, pp.35-44, 2009.
[3] J. Chao, E.T. Chang, S.K.S. So, "Hepatitis B and Liver Cancer Knowledge and Practices among Healthcare and Public Health Professionals in China: A Cross-sectional Sudy", Bio Med Central Public Health, Vol.10, Issue.98, pp.1-11, 2010.
[4] C. Niederhauser, T. B. Mansouri, M. Graziani, M. Stolz, C. Tinguely, P. Schneider, "Blood Donor Screening: How to Decrease the Risk of Transfusion?transmitted Hepatitis B Virus", Swiss Med Wkly, Vol.138, pp.134?41, 2008.
[5] G.M. Calderón, F. González-Velázquez , C.R. González-Bonilla, B. Novelo-Garza, J.J. Terrazas , M.L. Martínez-Rodríguez, "Prevalence and Risk Factors of Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus in Multiply Transfused Recipients in Mexico", Transfusion, Vol.49, pp.2200?2207, 2009.
[6] S.A. Kafi-abad, H. Rezvan, H. Abolghasemi, A. Talebian, "Prevalence and Trends of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus among Blood Donors in Iran, 2004 through 2007", Transfusion, Vol.49, Issue.2214-2220, 2009.
[7] Y.H. Shi, "Correlation Between Hepatitis B virus Genotypes and Clinical Outcomes", Journal of Infectious Disease, Vol.65, pp.476?482. 2012.
[8] S.O. Odemuyiwa, M.N. Mulders, O.L. Oyedele, S.O. Ola, G.N. Odaibo, D.O. Olaleye, "Phylogenetic Analysis of New Hepatitis B Virus Isolates from Nigeria Supports Endemicity of Genotype E in West Africa", Journal of Medical Virology, Vol.65, pp.463-469, 2001.
[9] D. Lavanchy, ?Hepatitis B Virus Epidemiology, Disease Burden, Treatment, and Current and Emerging Prevention and Control Measures,? Journal of Viral Hepatitis, Vol.11, No.2, pp.97-107, 2004.
[10] J.Z. Saidu, P.O. Oyedoh, G. Ngagwaonye, "Hepatitis B Surface Antibody (HBSAB) and Co-Inffection with Malaria Parasite in Benin City, Edo State, Nigeria", International Journal of Scientific Research in Biological Sciences, Vol.7, Issue.2, pp.158-162, 2020.
[11] E.D. Gurmu, B.K. Bole, P.R. Koya, E.D. Gurmu, B.K. Bole, P.R. Koya, "A Mathematical Model for Co-infection of HPV and HSV-II with Drug Resistance Compartment", International Journal of Scientific Research in Mathematical and Statistical Sciences, Vol.7, Issue.2, pp.34-46, 2020.
[12] P. Van Damme, K. Van Herck, ?A review of the long-term protection after Hepatitis A and B vaccination,? Travel Medicine and Infectious Disease, Vol.5, No.2, pp.79-84, 2007.
[13] S. Lok, B. J. McMahon, ?Chronic Hepatitis B,? The New England Journal of Medicine, Vol.346, No.22, pp.1682-1683, 2002.
[14] World Health Organization. "Department of Communicable Disease Surveillance and Response ", Unpublished, 2009.
[15] World Health Organization. "Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Post Exposure Prophylaxis", Unpublished, 2011.
[16] A. Kay, F. Zoulim, ?Hepatitis B Virus Genetic Variability and Evolution,? Virus Research, Vol.127, No.2, pp.164-176. 2018.
[17] J. Mokaya, A.L. McNaughton, L. Burbridge, T. Maponga, G. O?Hara, M. Andersson, "A Blind Spot Confronting the Stigma of Hepatitis B Virus (HBV) Infection?A Systematic Review", Wellcome Open Res. Vol.3, p.29. 2018.
[18] G.A. O?Hara, A.L. McNaughton, T. Maponga, P. Jooste, P. Ocama, R. Chilengi, "Hepatitis B Virus Infection as a Neglected Tropical Disease", PLos Negl Trop Dis, Vol.11, pp.42-58, 2017.
[19] M.M. Alam, S.Z. Zaidi, S.A. Malik, A. Naeem, S. Shaukat, S. Sharif, M. Angez, A. Khan, J.A. Butt, "Serology Based Disease Status of Pakistani Population Infected with Hepatitis B virus", BMC Infect Dis, Vol.7, p.64, 2007.
[20] R. Zhu, H. Zhang, H. Yu, H. Li, Y.Q. Ling, X.Q. Hu, H.G Zhu, "Hepatitis B Virus Mutations Associated with in Situ Expression of Hepatitis B Core Antigen, Viral Load and Prognosis in Chronic Hepatitis B Patients", Pathol Res Pract, Vol.204, pp.731-742, 2008.
[21] D. Glebe, S. Urban, ?Viral and Cellular Determinants Involved in Hepadnaviral Entry,? World Journal of Gastroenterology, Vol.13, No.1, pp.22-38, 2007.
[22] A. Salisu, M. D. Muktar, A. I. Salisu, Y. Abdulhadi, M. Umar, ?A Survey on the Prevalence of Hepatitis B Virus and Predisposing Factors among Blood Donors in two General Hospitals in Jigawa State Nigeria,? International Journal of Health and Medical Sciences, Vol.3, No.2, pp.29-37, 2017.
[23] O. A. Ejele, C. A. Nwauche, O. Erhabor, ?The Prevalence of Hepatitis B Surface Antigenaemia in HIV Positive Patients in the Niger Delta Nigeria,? Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria, Vol.13, No.2, pp.175-179, 2003.
[24] O. M. David, A. O. Oluduro, A. B. Ariyo, D. Ayeni, O. Famurewa, ?Sero-epidemiological Survey of Hepatitis B Surface Antigenaemia in Children and Adolescents in Ekiti State, Nigeria,? Journal of Public Health and Epidemiology, Vol.5, No.1, pp.11-14, 2013.
[25] J. H. Kao, D. S. Chen, ?Global Control of Hepatitis B Virus Infection,? The Lancet Infectious Diseases, Vol.2, No.7, pp.395-403, 2002.
[26] L. A. Eller, M. A. Eller, B. Ouma, P. Kataaha, D. Kyabaggu, R. Tumusiime, H. Kibuuka, ?Reference Intervals in Healthy Adult Ugandan Blood Donors and their Impact on Conducting International Vaccine Trials,? Plos One, Vol.3, No.12, pp.1-6, 2008.
[27] C. O. Imarengiaye, M. E. Enosolease, P. E. Iribhogbe, A. E. Ehigiegba, ?Risk of Transfusion-transmitted Hepatitis C Virus in a Tertiary Hospital in Nigeria,? Public Health, Vol.120, No.3, pp.274-278, 2006.
[28] S. I. Gan, S. M. Devlin, N.W. Scott-Douglas, K.W. Burak, ?Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection,? Canadian Journal of Gastroenterology and Hepatology, Vol.19, No. 10, pp.625-629, 2005.