Histopathological Analysis of the Kidney of Alloxan Induced Diabetic Albino (Wistar Strain) Rat Treated with Musa paradisiaca (Plantain) Stem Juice

L.U. Onah¹ , S.O. Oguche²

Section:Research Paper, Product Type: Journal-Paper
Vol.9 , Issue.2 , pp.8-13, Apr-2022

Online published on Apr 30, 2022

Copyright © L.U. Onah, S.O. Oguche . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Multiple organ failure is the cause of death in diabetes mellitus and hyperglycemia induce oxidative stress is responsible for major diabetic complications including nephropathy. Traditional plant medicines or herbal formulations might offer a natural key to unlock complications of diabetes. 35 healthy albino rats (Wister strain) of both sexes (80g-110g) were procured from the Animal House at University of Nigeria, Nsukka. The rats were separated into 7 groups after induction with alloxan. The present study investigate the histopathological effects of Musa paradisiaca stem juice on the kidney of 150mg/kg alloxan induced diabetic rats, treated with 0.21mL/kg/bw/rat/day and 0.43mL/kg/bw/rat/day Musa paradisiaca stem juice. The result revealed that among the seven groups both sub-diabetic and diabetic rats treated with 0.21mL/kg/bw/rat/day Musa paradisiaca stem juice showed mild reduction in cellularity of glomerulus and increase in Bowman’s space as compared to the diabetic control with hyper cellularity in glomerulus and narrowing of bowman’s space while 0.43mL/kg/bw/rat/day day Musa paradisiaca stem juice showed a significant reduction in cellularity of the glomerulus and significant increase in Bowman’s space of both sub-diabetic rats and diabetic rats. This study therefore suggest that, the therapeutic actions of plantain stem juice has reduced the cellularity of the glomerulus and concomitantly increase the Bowman’s space of both sub-diabetic rats and diabetic rats. And as such can be used in the treatment of diabetic kidney disease.

Key-Words / Index Term :
Diabetes; Histopathological; Kidney; Alloxan; Musa paradisiaca

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