Determination of the optimal conditions to produce lovastatin compound from the fungus (Penicillium digitatum)

Hajar Nasser¹ , Nawal Ali² , Reem Salamah³ , Amjad Deeb⁴

Section:Research Paper, Product Type: Journal-Paper
Vol.10 , Issue.3 , pp.25-28, Jun-2023

Online published on Jun 30, 2023

Copyright © Hajar Nasser, Nawal Ali, Reem Salamah, Amjad Deeb . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
This study was done to determine an ability of the fungus (Penicillium digitatum) to produce lovastatin compound after do experiments by using method of Solid State Fermentation (SSF). The fermentation method was carried out within presence of a mixture of three organic substrates (wheat bran, oat bran, soybeans), carbon and nitrogen sources (potato peels powder, yeast extract, milk powder) at different environmental conditions (temperature degrees, acidity degrees, concentration of spore suspension, and period time). After that, lovastatin compound was extracted by using ethanol 95%. This study showed that the highest concentration of lovastatin reached 155.93 mg/g of dry substrate after 10 days from fermentation in temperature degree 300C, pH=6, and concentration of spore suspension 108 spore/ml.

Key-Words / Index Term :
Fermentation, extraction, lovastatin, Fungi, Penicillium digitatum, Spectrophotometer.

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