Synthesis, Characterization and Evaluation of Biological Activity of 1, 3, 4- Thiadiazole Derivatives Containing Schiff Bases

Rajpal Jadhav¹ , Hansaraj Joshi² , Ramesh Ware³ , Sanjay Ubale⁴

Section:Research Paper, Product Type: Journal-Paper
Vol.11 , Issue.5 , pp.13-18, Oct-2024

Online published on Oct 31, 2024

Copyright © Rajpal Jadhav, Hansaraj Joshi, Ramesh Ware, Sanjay Ubale . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Synthesis of Schiff bases via conventional methods is described, involving the condensation reaction between aldehyde and 1, 3, 4-thiadiazole 2-amine. After purification and characterization, seven Schiff bases (5a-5g) were successfully synthesized. Physical characteristics were recorded, and purity was confirmed through various techniques including TLC, melting point determination, elemental analysis, FT-IR, 1H-NMR, and mass spectral studies. FT-IR spectra showed characteristic peaks confirming the formation of Schiff bases, while 1H-NMR spectra provided insights into molecular structure. Biological screening against bacterial species revealed varying degrees of antibacterial activity, with compounds 5e, 5f, and 5g exhibiting notable effectiveness against E. coli. Structure-activity relationship analysis suggested that electron-withdrawing groups enhance antibacterial potency. Additionally, some compounds demonstrated strong antifungal effects against various fungi, indicating the potential of these compounds as antimicrobial agents. Further research is warranted to elucidate their mechanisms of action and explore additional properties before considering them for medicinal use.

Key-Words / Index Term :
Schiff bases, 1, 3, 4-thiadiazole 2-amine, biological activity etc

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