Synthesis of Isoquinolines Using Copper Nanoparticles Supported on Carbon Microsphere Cu-NP/C/PEG-400 as Heterogeneous Reusable Catalyst

Shrinivas L. Nakkalwar¹ , Hanmant M. Kasralikar² , Nitish S. Kaminwar³

Section:Research Paper, Product Type: Journal-Paper
Vol.11 , Issue.5 , pp.23-28, Oct-2024

Online published on Oct 31, 2024

Copyright © Shrinivas L. Nakkalwar, Hanmant M. Kasralikar, Nitish S. Kaminwar . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
A new, eco-friendly method for synthesizing 1-Phenyl Isoquinoline derivatives has been developed using Cu-NP/C/PEG-400 as a heterogeneous, reusable catalyst. This method involves the activation of C-H and N-N bonds in 1-(diphenylmethylene) hydrazine and substituted aryl acetylenes. The process utilizes Cu-NP/C as an oxidant and AgSbF6 as an additive, all within a biodegradable PEG-400 solvent. This approach offers several advantages, including a straightforward extraction procedure, high atom economy, a wide substrate scope, and high product yields, making it an efficient and sustainable protocol for producing isoquinoline derivatives.

Key-Words / Index Term :
Green synthesis, Heterogeneous catalyst, Cu-NP/C, Biodegradable solvent

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