A Kinetic and Mechanistic Approach for Oxidation of Isoprenaline by Potassium Dichromate

Syed Y.H.¹

Section:Research Paper, Product Type: Journal-Paper
Vol.11 , Issue.5 , pp.72-74, Oct-2024

Online published on Oct 31, 2024

Copyright © Syed Y.H. . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
The oxidation of Isoprenaline, a pharmaceutical compound was studied kinetically in an aqueous medium using potassium dichromate as the oxidant using spectrophotometer at 520 nm. The reaction rate was found to be first order with respect to both the substrate and the oxidant while it is independent of acid concentration. Stoichiometric analysis revealed that one mole of potassium dichromate is required to oxidize three moles of Isoprenaline. Initially a complex intermediate i.e. chromate ester is formed in the rate determining step which later oxidized to form the product. The activation parameters like change in enthalpy ?H, change in entropy ?S and Gibbs free energy change ?G, were calculated based on the results. The positive value of enthalpy change indicates the reaction is endothermic while the negative value of change in entropy indicates highly ordered reaction. The reaction product was found Isoprenaline N-oxide which is easy to remove from the aqueous system. The research will be very helpful for the degradation of Isoprenaline in aqueous medium by dichromate in bulk and maintaining the environmental balance.

Key-Words / Index Term :
Pharmaceuticals, Kinetics, Oxidation, Aqueous, Enthalpy

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