Potentiometric Study of Complexes of Some Antibacterial Medicinal Drugs with Transition Metal Ions

A.S. Jagtap¹ , S.V. Thakur²

Section:Research Paper, Product Type: Journal-Paper
Vol.11 , Issue.5 , pp.80-86, Oct-2024

Online published on Oct 31, 2024

Copyright © A.S. Jagtap, S.V. Thakur . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
This study investigates the potentiometric behavior of complexes formed between selected antibacterial medicinal drugs and transition metal ions. The study aims to elucidate the stability constants of these complexes and explore the implications for drug efficacy and metal ion chelation. Potentiometric titrations were performed to determine the stability constants of the drug-metal complexes in aqueous solutions at varying pH levels. The results provide insights into the coordination chemistry of these drugs, which could have significant implications for their pharmacological activity. Antibacterial drugs are widely used to treat bacterial infections, and their effectiveness can be influenced by their ability to form complexes with metal ions. Transition metal ions such as Fe²?, Co²?, Cu²?, and Zn²? play crucial roles in biological systems and can interact with drugs to form stable complexes. The study of these complexes is essential for understanding drug bioavailability.

Key-Words / Index Term :
Potentiometric titration, Antibacterial drugs, Transition metal ions, Stability constants, Complexation

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