Telatinib, as potential Drug in Structure of Plasmodium falciparum

Ivan Vito Ferrari¹

Section:Research Paper, Product Type: Journal-Paper
Vol.9 , Issue.6 , pp.69-71, Dec-2021

Online published on Dec 31, 2021

Copyright © Ivan Vito Ferrari . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Thioredoxin reductase (TrxR) is crucially involved in redox homeostasis and essential for Plasmodium falciparum. This communication, reported a first-time important Docking study by in Silico approach, using AutoDock Vina. After a selective analysis of over 300 drugs, processed with Pyrx (a Virtual Screening software into the active site of protein ( ID PDB 4J56 Thioredoxin reductase 2 Chain A), it investigated the excellent value of Binding Energy of Telatinib estimated by Pyrx software, ca. -12 kcal/mol. These results are comparable to the crystallized ligand FAD ( Flavin-Adenine-Dinucleotide), situated in the above-mentioned protein.

Key-Words / Index Term :
Autodock Vina, and Telatinib

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