Lapatinib (Tyverb®) Against Zika Virus

Ivan Vito Ferrari¹

Section:Research Paper, Product Type: Journal-Paper
Vol.9 , Issue.6 , pp.79-81, Dec-2021

Online published on Dec 31, 2021

Copyright © Ivan Vito Ferrari . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
After Docking analysis of over 300 drugs, processed with Pyrx, a small Virtual Screening software, into the active site of protein of RNA-directed RNA polymerase NS5, ( ID PDB 6LD3 chain A), could be an excellent candidate drug against Zika virus. Indeed, from the results of Autodock Vina has a good Binding affinity value, ca. -9.6 kcal mol -1, good estimation inhibitory constant (Ki) value ca. 91 nM and goof Ligand efficiency ca -0.24 kcal mol -1. These results are higher to the crystallized ligand G8O ( 2,4-dimethoxy-5-thiophen-2-yl- benzoic acid ) complexed in this studied protein.

Key-Words / Index Term :
Lapatinib, Zika virus (ZIKV), Autodock 4, Autodock Vina

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