Formulation and Evaluation of Bioadhesive Buccal Tablets of Esomeprazole

Zeenath Ruhy¹

Section:Research Paper, Product Type: Journal-Paper
Vol.5 , Issue.8 , pp.12-20, Aug-2019

Online published on Aug 31, 2019

Copyright © Zeenath Ruhy . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

View this paper at   Google Scholar | DPI Digital Library

XML View     PDF Download

How to Cite this Paper

Abstract :
Esomeprazole is an anti ulcerative agent (proton pump inhibitor) which is used in treating gastro esophageal reflux disease. The main objective of the study was to formulate and evaluate bioadhesive buccal tablets to overcome the degradation in the acidic media of gastrointestinal tract, and to avoid the first pass metabolism in liver. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesive polymers like Xanthane gum, Chitosan, guar gum and hydroxy propyl methyl cellulose LV- 15 in different ratios. The physicochemical compatibility of drug and polymers was studied by FT-IR spectroscopy. Prepared tablets were evaluated for permeation study through porcine buccal mucosa, in vitro drug release, bioadhesion strength, swelling index, moisture absorbance, surface pH, ex vivo residence time. Among the prepared formulation containing guar gum (Fc2) was found to be optimized formulation which showed the higher flux 2.471 mg hr-1cm-2 than the pure drug solution (0.496 mghr-1cm-2), and bioadhesive strength of 2.68±0.03 N and 0.95±0.08 mJ. In vitro percentage drug release of optimized formulation was 98.32%±0.23 at the end of 6 hours. The Fc2 values of percentage drug release put in kinetic data, it followed Higuchi model (R2 is 0.982).

Key-Words / Index Term :
Bioadhesive buccal tablet, Chitosan, Esomeprazole, Guar gum, Xanthane gum

References :
[1] Chien YW, “Novel drug delivery systems”. Marcel Dekker Inc., New York, 2nd ed; Volume 50: pp.139, 1992.
[2] Shiledar RR, Tagalpallewar AA, Kokare CR. “Formulation and in vitro evaluation of xanthane gum-based bilayered mucoadhesive buccal patches of zolmitriptan”. Carbohydrate polymers, Volume 30, issue.101, pp.1234-42, 2014.
[3] Matsyagiri. L, Jyothi. G, Mahipal Reddy. D, Narayana. M, Shravya. K, Sindhuja. S, Swarnalatha. D, Gowri Shankar. NL, “Design and in vitro Evaluation of Mucoadhesive Buccal Tablets of Chlorpheniramine Maleate”. International Journal of Pharmaceutical Sciences and Letters, Volume 2, issue.4, pp.102-109, 2012.
[4] Gowtham. N, Subhashis Debnath, Niranjan Babu. M, “Formulation and evaluation of mucoadhesive bilayer buccal tablets of amphotericin B hydrocarbon”, International Journal of Novel Trends in Pharmaceutical Sciences, Volume 5, issue.4, pp.107-113, 2015.
[5] Kumar K, Velmurugan S. “Formulation and in vitro evaluation of glipizide mucoadhesive buccal tablets”, International Journal of Pharmaceutical Biological Sciences, volume 4, issue.2, pp.594- 607, 2013.
[6] Kianfar F, Antonijevic M, Chowdhry B, Boateng JS. “Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs”. Colloids and surfaces B: Biointerfaces, volume 103, issue.1, pp.99-106, 2013.
[7] Sachin, Darekar. S, Khadabadi.SS, Shahi. SR, “Formulation and evaluation of bilayer buccal tablet of sumatriptan succinate”, International Journal of Pharmacy and Pharmaceutical Sciences, volume 6, issue.6, pp.469-475, 2014.
[8] Matsyagiri. L, Jagadeesh. P, Mounika. B, Srinivas. V, Theja. V, Madhiha Jabeen and Dr. K.Hemamalini, “Effect of solvents on Spectrophotometric Estimation of Tinidazole in bulk and dosage forms”, World Journal of Pharmaceutical Research, Volume7, issue.9, pp.1742-1754,2018.
[9] Leon Lachman and Joseph B Schwartz, “Pharmaceutical Dosage Forms: Tablets”. Marcel Dekker, Philadelphia. 1, pp.171-194, 2005.
[10] Ansel H, Nicholas G. “Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems”. 9th edition Lippincott Williams and Wilkins: 1, pp.225-37, 2010.
[11] Arun Raj R, Anjana Ashok, Josna PB, Reshma RR. “Design and evaluation of mucoadhesive bilayer tablets of Salbutamol sulphate”. International Research Journal of Pharmacy, volume 5, issue.5, pp.365-368, 2014.
[12] Ismail, B., Dr.Patel, MS., Dr Patel, KR., Dr. Patel,N. M., “Buccal Bioadhesive Drug Delivery System”. International Journal of Pharmacy and Biological Sciences. volume 2, issue.1, pp.49-58, 2013.
[13] Nishan Bobade, N., Sandeep, C., Vikrant, P.W., Dr. Pande, S.D., Dr. Tapar, K.K., “A Review on Buccal Drug Delivery System”. International Journal of Pharmaceutical Sciences and Research. Volume.3, issue.1, pp. 35-40, 2013.