Recent Advances in Nanotechnology-Based Formulations for Curcumin Delivery

Sachin Sharma¹ , R.K. Roy²

1. Master of Pharmacy, H.R. Institute of Pharmacy, Morta, Ghaziabad, Uttar Pradesh, India.
2. H.R. Institute of Pharmacy, Morta, Ghaziabad, Uttar Pradesh, India.

Section:Review Paper, Product Type: Journal-Paper
Vol.10 , Issue.3 , pp.45-52, Mar-2024

Online published on Mar 31, 2024

Copyright © Sachin Sharma, R.K. Roy . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Curcumin, extracted from the turmeric plant, demonstrates notable therapeutic potential such as anti-inflammatory, antioxidant, and anticancer properties. Nonetheless, its clinical utility is hindered by limited bioavailability. In recent years, nanotechnology-based formulations have emerged as a transformative approach to address this challenge and enhance the delivery of curcumin. This review provides a comprehensive overview of recent advances in nanotechnology-based formulations for curcumin delivery. The first section delves into various nanoparticle formulations, including liposomes, polymeric nanoparticles, and micelles, highlighting their structures and discussing advantages and limitations in curcumin delivery. The subsequent section focuses on transferosomes, emphasizing their unique characteristics in facilitating transdermal curcumin delivery. Additionally, the review explores combination therapies involving curcumin and other agents within nanocarrier systems, such as the synergistic effects observed with piperine. Targeted delivery systems represent another key aspect, with an examination of recent developments in delivering curcumin to specific tissues or cells using nanocarriers. Surface modifications, designed to enhance the stability and bioavailability of curcumin-loaded nanocarriers, are discussed in a dedicated section. Furthermore, the potential and challenges of intranasal delivery for curcumin using nanotechnology-based formulations are explored. The review concludes by addressing current challenges in the clinical translation of nanotechnology-based curcumin formulations and proposing future perspectives for advancing this field. The integration of nanotechnology into curcumin delivery holds significant promise for unlocking the full therapeutic potential of this natural compound.

Key-Words / Index Term :
Curcumin, Nanotechnology, Drug Delivery, Transferosomes, Combination Therapy

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