Advances in Phytosome Technology for Enhanced Bioavailability of Curcumin and Piperine

Manish Kumar Singh¹ , R.K. Roy²

Section:Review Paper, Product Type: Journal-Paper
Vol.10 , Issue.6 , pp.28-35, Jun-2024

Online published on Jun 30, 2024

Copyright © Manish Kumar Singh, R.K. Roy . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Curcumin and piperine, bioactive compounds derived from turmeric and black pepper respectively, have garnered significant attention due to their potent antioxidant, anti-inflammatory, and anticancer properties. Despite their therapeutic potential, both compounds suffer from poor bioavailability, primarily due to low solubility and rapid metabolism. Phytosome technology, an innovative drug delivery system, offers a promising solution to these limitations by enhancing the bioavailability and therapeutic efficacy of these phytochemicals. This review explores the advances in phytosome technology aimed at improving the bioavailability of curcumin and piperine. Phytosomes are complex structures where phytochemicals are bound to phospholipids, forming a lipid-compatible molecular complex that enhances absorption and bioavailability. Recent studies have demonstrated that curcumin and piperine, when formulated into phytosomes, exhibit significantly improved pharmacokinetic profiles, leading to enhanced therapeutic outcomes. This review delves into the mechanisms by which phytosome technology enhances bioavailability, including improved solubility, protection from metabolic degradation, and facilitated cellular uptake. Furthermore, we discuss the latest advancements in phytosome formulation techniques, such as the use of novel phospholipid carriers, optimization of particle size, and surface modifications to target specific tissues. The integration of nanotechnology with phytosome delivery systems is also highlighted, offering synergistic benefits for controlled and sustained release of curcumin and piperine. In conclusion, phytosome technology represents a substantial advancement in the delivery of curcumin and piperine, addressing their bioavailability challenges and unlocking their full therapeutic potential. Continued research and development in this field are essential for translating these findings into clinical applications, potentially leading to more effective treatments for a variety of diseases.

Key-Words / Index Term :
Curcumin, Piperine, Phytosome, Bioavailability, Phospholipid, Nanotechnology, Drug delivery

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