Acute Effect of Cadmium Chloride on the Histological Structure of Liver in Japanese Quail Coturnix coturnix japonica

Hind A. Mohammed¹ , Ameer M. Taha²

Section:Research Paper, Product Type: Journal-Paper
Vol.8 , Issue.4 , pp.12-17, Aug-2021

Online published on Aug 31, 2021

Copyright © Hind A. Mohammed, Ameer M. Taha . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
Cadmium is one of the most dangerous heavy metals for its long life and its acute and chronic effects. The current research aims to identify the effect of acute exposure to cadmium chloride on the histological structure of the liver in one of the economic birds, which is the Japanese quail, Coturnix coturnix japonica. The study included two groups, a control group, and an experimental group. The birds of the experimental group were dosed to a concentration of 50mg/kg for four continuous days. The birds were sacrificed 4,15,30,60 days after the start of the experiment. The results of the histological examination of the liver showed the emergence of many lesions in the four periods, to varying degrees between them. Among the most prominent of these is the appearance of necrosis, vacuolation, hemorrhage, ballooning swelling, congestion, infiltration of inflammatory cells, as well as enlargement of the sinuses and Kupffer cells hyperplasia. The study concluded that the cadmium chloride causes much tissue damage to the body of the quail bird and that it is necessary to take into account not to be exposed to this element to maintain its economic value.

Key-Words / Index Term :
Cadmium chloride; Japanese quail; Liver

References :
[1] P.B. Tchounwou, C.G. Yedjou, A.K. Patlolla, D.J. Sutton, "Heavy Metal Toxicity and the Environment," Mole. Cline. and Environ. Toxic., 133–164, 2012.
[2] J.J. Kim, Y.S. Kim, V.Kumar, "Heavy metal toxicity: An update of chelating therapeutic strategies," J. of trace elements in med. & bio;Vol. 54,ppm226–231. 2019.
[3] L .Järup, " Hazards of heavy metal contamination,` British med. Bull,Vol. 68,pp,167–182, 2003.
[4] K. Rehman, F. Fatima, I. Waheed, M. Akash," Prevalence of exposure of heavy metals and their impact on health consequences," J. of cell. biochem., Vol.119, Issue. 1, pp.157-184, 2018.
[5] X. Wu, S.J. Cobbina, G. Mao, H. Xu, Z. Zhang, L.Yang, "A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment,". Environ. Sci. & Poll. Res. Interm Vol.23, Issue. 9, pp.8244-8259, 2016.
[6] A.F. Khafaga, M.E. Abd El-Hack, A.E. Taha, S.S. Elnesr, "Alagawany M. The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review," Environ. Sci. & Poll. Res. Inter., Vol.26, Issue. 5, pp.4588-4604, 2019.
[7] M. Nishijo, H. Nakagawa, Y. Suwazono, K. Nogawa, T. Kido , "Causes of death in patients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of a follow-up study in Japan," BMJ open, Vol.7, Issue. 7, pp.e015694, 2016.
[8] J. Li, C. Zhang, J. Lin, J. Yin, J. Xu, Y.Chen, " Evaluating the bioavailability of heavy metals in natural-zeolite-amended aquatic sediments using thin-film diffusive gradients,". Aqua. & fish., Vol.3, Issue. 3, pp.122-128, 2018.
[9] R. Mallya, P.K. Chatterjee, N.A. Vinodini, Chatterjee P, P. Mithra,"Moringa oleifera Leaf Extract: Beneficial Effects on Cadmium Induced Toxicities – A Review," JCDR., Vol.11, Issue. 4, pp.CE01-CE04, 2017.
[10] M. Mizutani, "Establishment of inbred strains of chicken and Japanese quail and their potential as animal models," Expert. Anim, Vol.51, Issue. 5, pp.417-429, 2002.
[11] D, Huss, G. Poynter, R. Lansford, "Japanese quail (Coturnix japonica) as a laboratory animal model" Lab animal, Vol.37, Issue. 11, pp.513-519, 2008.
[12] H.K. Zorab, K.A. Salih, "Development of the wing bones in quail’s embryo; Coturnix japonica," Iraqi J. Vet. Sci. M Vol.35, Issue. 1, pp.129-137, 2021.
[13] A.A. Al-Kshab, O.Q.Yehya, "Determination of the lethal concentration 50% (LC50) of lead chloride and its accumulation in different organs of Gambusia affinis fish," Iraqi J. Vet. Sci. , Vol.35, Issue. 2, pp.361-367, 2021.
[14] H.A. Al-Hajj, "Optical Microscopy, Theory and Practice,". 4th ed. Al-Masirah House for Publishing, Distribution, and Printing , Jordan, pp. 238 , 2015.
[15] H.H. Hamid, A.M. Taha, "Anatomical and histological structure of the cornea in Sparrow hawk Accipiter nisus," Iraqi J. Vet. Sci. Vol.35, Issue. 3, pp.437-442, 2021.
[16] Taha AM. Comparative histological and histochemical study of the ileum in two different birds.," Iraqi J. Vet. Sci. Vol.35, Issue. 3, pp.479-487, 2021.
[17] X. Dai, C. Xing, H. Cao, J. Luo, T. Wang, P. Liu, X. Guo, G. Hu, C. Zhang, "Alterations of mitochondrial antioxidant indexes and apoptosis in duck livers caused by Molybdenum or/and cadmium," Chemosphere, Vol.193, pp.574-580, 2018.
[18] C. Tao, B. Zhang, X. Wei, M. Zhao, Z. Sun, S. Wang, J. Bi, D. Qi, L. Sun, N. Zhang, "Effects of dietary cadmium supplementation on production performance, cadmium residue in eggs, and hepatic damage in laying hens", Environ. Sci. & Poll. Res. Inter., Vol.27, Issue. 26, pp.33103-33111, 2020.
[19] A. Rani, A. Kumar, A. Lal, M. Pant, " Cellular mechanisms of cadmium-induced toxicity: a review," Inter. J. of environ. Heal. res., Vol.24, Issue. 4, pp.378-399, 2014.
[20] B.I. AL-Kaisie, "Pathological & Residues study of Cadmium Chloride in rabbits,". Iraqi J. of Veter. Med, Vol.32, Issue. 2, pp.207-213, 2008.
[21] A.S. Farhan, S.T.Jasim, "Cadmium Toxicity and some Target Organs: A Review," Al-Anbar J. of Veter. Sci., Vol.13, Issue. 2, pp.17-26, 2020.?
[22] R. Zhang, Y. Liu, L. Xing, N. Zhao, Q. Zheng, J. Li, J.Bao, "The protective role of selenium against cadmium-induced hepatotoxicity in laying hens: expression of Hsps and inflammation-related genes and modulation of elements homeostasis,". Eco. & environ. safe., Vol.159,pp.159-205, 2018.
[23] J. Ge, C. Zhang, Y.C. Sun, Q, Zhang, M.W. Lv, K. Guo, J.L. Li, "Cadmium exposure triggers mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activationm" Sci. of the total environ, Vol.689, pp.1160-1171, 2019.