Biosynthesis of colloidal Copper Oxide Nanoparticles using Manilkara hexandra (Roxb.) Dubard leaf extract and its Physicochemical Characterization and Pharmaceutical Evaluation

A Antony Lawrence¹ , J Thomas Joseph Prakash²

Section:Research Paper, Product Type: Isroset-Journal
Vol.6 , Issue.6 , pp.57-68, Dec-2018

CrossRef-DOI:   https://doi.org/10.26438/ijsrpas/v6i6.5768

Online published on Dec 31, 2018

Copyright © A Antony Lawrence, J Thomas Joseph Prakash . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
In the present investigation, plant mediated bio-synthesis of copper oxide nanoparticles is synthesized using Manilkara hexandra leaf extract and were further characterized using Fourier transform infrared spectroscopy (Presence of bio-molecules), UV-vis spectroscopy (250-300 nm), Field electron scanning electron microscope (30 to 60 nm), Energy dispersive x-ray analysis (Cu, O elements), X-ray diffraction analysis (face-centered cubic structure ), Particle size analyser (343 nm) , Zeta potential (-9.50mV). The Thermogravimetry/Differential Thermal Analysis and Differential scanning calorimetry is also examined to find the stability of materials. This confirms that copper oxide nanoparticles are well formed and synthesized. They are further tested with anti-microbial assays and antioxidant evaluation (DPPH method in-vitro) these reports show high estimation. This confirms that the copper oxide nanoparticles can be produced in large scale and can be implied for prevention of food , crops and drug delivery system.

Key-Words / Index Term :
Manilkara hexandra, Copper oxide nanoparticles, Anti-microbial assays, DPPH method

References :
[1]. A. Nostro, M.P. Germano, V. Dangelo, A. Marino, M.A. Cannatelli, “Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity”, Letters in Applied Microbiology,Vol. 30, Issue.,5, pp. 379-384, 2000.
[2]. T.N.V.K.V Prasad, Elumalai E.K, “Biofabrication of Ag nanoparticles using M. oleifera leaf extract and their antimicrobial activity”, Asian Pacific Journal of Tropical Biomedicine, Vol. 1, Issue.,6, pp. 439-442, 2011.
[3]. B.A. Makwana, D.J. Vyas, K.D. Bhatt, V.K. Jain, Y.K. Agrawal, “Highly stable antibacterial silver nanoparticles as selective fluorescent sensor for Fe3þ ions”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 134, pp. 73-80, 2015.
[4]. V. Kumar , S.K. Yadav, “Plant-mediated synthesis of silver and gold nanoparticles and their applications”, Journal of Chemical Technology & Biotechnology, Vol. 84, Issue.,2,pp.151-157,2009.
[5]. A.K. Chatterjee, R.K. Sarkar, A.P. Chattopadhyay, P. Aich, R. Chakraborty, T. Basu, “A simple robust method for synthesis of metallic copper nanoparticles of high antibacterial potency against E. coli”, Nanotechnology, Vol. 23, pp.1-11, 2012.
[6]. B. Ajitha, Y.A.K. Reddy, P.S. Reddy, Y. Suneetha, H.J. Jeon, C.W. Ahn, “Instant biosynthesis of silver nanoparticles using Lawsonia inermis leaf extract: Innate catalytic, antimicrobial and antioxidant activities”, Journal of Molecular Liquids, Vol. 219,pp. 474-481,2016.
[7]. K. Sneha, M. Sathishkumar, S. Y. Lee, M. A. Bae, Y-S. Yun, “Biosynthesis of Au nanoparticles using cumin seed powder extract”, Journal of Nanoscience and Nanotechnology, Vol.11, Issue.,2,pp. 1811- 1814,2011.
[8]. P. Reddy Prasad, S. Kanchi, E.B. Naidoo, “In-vitro evaluation of copper nanoparticles cytotoxicity on prostate cancer cell lines and their antioxidant, sensing and catalytic activity: One-pot green approach”, Journal of Photochemistry and Photobiology B: Biology, Vol. 161, pp. 375-382,2016.
[9]. J. Suarez-Cerda, H. Espinoza-Gomez, G. Alonso-Nunez, I.A. Rivero, Y. Gochi-Ponce, L.Z. Flores-Lopez, “A green synthesis of copper nanoparticles using native cyclodextrins as stabilizing agents”, Journal of Saudi Chemical Society, Vol. 21, Issue.,3,pp. 341-348,2017.
[10]. M.S. Niasari, F. Davar, “Synthesis of copper and copper (I) oxide nanoparticles by thermal decomposition of a new precursor”. Materials Letters, Vol. 63,Issue.,3-4, pp. 441- 443,2009.
[11]. G. Ren, D. Hu, E.W.C. Cheng, M.A. Vargas-Reus, P. Reip, R.P. Allaker, “Characterisation of copper oxide nanoparticles for antimicrobial applications”. International Journal of Antimicrobial Agents, Vol. 33, Issue.,6, pp. 587-590,2009.
[12]. R. Dastjerdi, M. Montazer, “A review on the application of inorganic nanostructured materials in the modification of textiles: Focus on antimicrobial properties”. Colloids and Surfaces B: Biointerfaces, Vol. 79, Issue.,1, pp.5-18,2010.
[13]. S Irudaya Monisha, G Dayana Jeyaleela,A.Anitha Immaculate and J Rosaline Vimala, “Comparative studies on yield and the phytochemical appraisal(Quality and Quantity) of Manilkara hexandra(Roxb) Dubard using leaf, stem, and bark”. Journal of Pharmacognosy and Phytochemistry. Vol.6, Issue.,4,pp. 2052-2058,2017.
[14]. J.B. Harborne, “Textbook of phytochemical methods”, 1st ed., Chapman and Hall, London, 1973.
[15]. Bhattacharya D, Rajinder G, “Nanotechnology and potential of microorganisms”. Critical Reviews in Biotechnology. Vol. 25, Issue.,4, pp.199-204,2005.
[16]. Mohamed S. Abdel-Aziz , Mohamed S. Shaheen , Aziza A. El-Nekeety , Mosaad A. Abdel-Wahhab. 2014. “Antioxidant and antibacterial activity of silver nanoparticles biosynthesized using Chenopodium murale leaf extract”. Journal of Saudi Chemical Society. Vol.18, Issue.,4, pp. 356-363,2014.
[17]. A. Azam, A.S. Ahmed, M. Oves, M.S. Khan, A. Memic, “Size-dependent antimicrobial properties of CuO nanoparticles against Gram-positive and -negative bacterial strains”. International Journal of Nanomedicine. Vol. 7, pp. 3527-3535, 2012.
[18]. P. Mulvaney, “Surface Plasmon Spectroscopy of Nanosized Metal Particles”. Langmuir. Vol.12, Issue.,3, pp. 788-800, 1996.
[19]. N. Ahmad, S. Sharma, V.N. Singh, S.F. Shamsi, A. Fatma, B.R. Mehta, “Biosynthesis of Silver Nanoparticles from Desmodium triflorum: A Novel Approach Towards Weed Utilization”. Biotechnology Research International. Vol. 2011, Article ID 454090, pp. 1-8, 2011.
[20]. A.S. Ethiraj, D.J. Kang, “Synthesis and characterization of CuO nanowires by a simple wet chemical method”. Nanoscale Research Letters. Vol. 7, Issue., 70, pp. 1-5, 2012.
[21]. L. Lin, P. Qiu, X. Cao, L. Jin, “Colloidal silver nanoparticles modified electrode and its application to the electroanalysis of Cytochrome c”. Electrochimica Acta. Vol. 53, Isssue., 16, pp. 5368-5372, 2008.
[22]. R. Sankar, A. Karthik, A. Prabu, S. Karthik, K.S. Shivashangari, V. Ravikumar, ”Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity”. Colloids and Surfaces B: Biointerfaces. Vol. 108, pp. 80-84, 2013.
[23]. Mohd Abdul Majeed Khan, Sushil Kumar , Maqusood Ahamed , Salman A Alrokayan and Mohammad Saleh AlSalhi. 2011. “Structural and thermal studies of silver nanoparticles and electrical transport study of their thin films”. Nanoscale Research Letters. Vol. 6:434,pp.1-8,2011.