Volume-10 , Issue-5 , Oct 2023, ISSN 2347-7520 (Online) Go Back

• Open Access   Article

  Hypericin As A Possible Natural Molecule For The Treatment Of Alzheimer`s Disease: Computationa Studies Focused On Beta-Secretase-1(or BACE1)

  Ivan Vito Ferrari

  Research Paper | Journal-Paper (IJSRBS)

  Vol.10 , Issue.5 , pp.68-70, Oct-2023

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  Abstract
  In this short communication, for the first time computational approach through Molecular Docking by Autodock Vina was performed for the treatment of Alzheimer’s disease. In this investigation, hundreds of natural molecules were investigated by the Virtual Screening method with the Pyrx program using the Beta-Secretase-1 protein in the Ligand Binding Site protein. From docking results, Hypericin has obtained an excellent binding energy value of -10.6 kcal/mol rather than other compounds investigated. Several biological studies are needed both to demonstrate the role of Hypericin in its mechanism and toxicity studies to evaluate whether this molecule can actually be useful for the treatment of Alzheimer`s disease.

  Key-Words / Index Term
  Autodock Vina, Hypericin, Docking method

  References
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  Citation
  Ivan Vito Ferrari, "Hypericin As A Possible Natural Molecule For The Treatment Of Alzheimer`s Disease: Computationa Studies Focused On Beta-Secretase-1(or BACE1)," International Journal of Scientific Research in Biological Sciences, Vol.10, Issue.5, pp.68-70, 2023

• Open Access   Article

  MicroRNA Biogenesis, Mechanisms of Function, Circulation and Application Role in Human Diseases

  Zahraa Isam Jameel

  Research Paper | Journal-Paper (IJSRBS)

  Vol.10 , Issue.5 , pp.71-80, Oct-2023

  Abstract

  Full-Text HTML

  References

  Citation

  Abstract
  The field of microRNA research has shown significant growth during the past decade. MicroRNA (miRNA) profiles have been identified as indicative of pathological conditions and have shown potential as biomarkers for diagnosing and evaluating human diseases. The mammalian genome encompasses a collection of more than 2200 miRNA genes, of which more than 1000 are attributed to the human genome. MicroRNAs (miRNAs) have been identified as regulators of essential cellular functions, such as development, differentiation, growth, and metabolism. The influence of gene proximity within the genome and their positioning within introns of coding genes, noncoding genes, and exons has significantly impacted gene expression levels in eukaryotic cells. MicroRNAs (miRNAs) exhibit substantial conservation throughout eukaryotic creatures, suggesting their enduring importance as a component of gene regulation networks. In this study, we want to elucidate fundamental inquiries about the role of microRNAs in human disease and the consequential clinical implications of these molecules. This discussion focuses on micro-RNAs` role in epigenetics, cancer, and metabolic illnesses. Illustrative instances are drawn from cholangiocarcinoma and nonalcoholic fatty liver disease.

  Key-Words / Index Term
  miRNA, human disease, biogenesis, canonical pathway, epigenetics

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  Citation
  Zahraa Isam Jameel , "MicroRNA Biogenesis, Mechanisms of Function, Circulation and Application Role in Human Diseases," International Journal of Scientific Research in Biological Sciences, Vol.10, Issue.5, pp.71-80, 2023