One Dimensional Numerical Study of Advection Diffusion of Calcium in a Hepatocyte Cell

Y.D. Jagtap¹ , N. Adlakha²

Section:Research Paper, Product Type: Isroset-Journal
Vol.6 , Issue.1 , pp.311-316, Feb-2019

CrossRef-DOI:   https://doi.org/10.26438/ijsrmss/v6i1.311316

Online published on Feb 28, 2019

Copyright © Y.D. Jagtap, N. Adlakha . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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Abstract :
In a human body, in almost all types of cells, the calcium plays a vital role in chemical signalling required for communication and maintenance of structure and functions of a cell. Almost all chemicals and proteins are produced in liver therefore, it is also known as body`s chemical factory. The calcium regulates all vital functions of a hepatocyte cell. The calcium concentration is tightly regulated by various processes like diffusion and advection in cytosol, binding with buffers etc. In this paper an unsteady state numerical approach is prefer to investigate the effect of advection and diffusion of calcium in a hepatocyte cell. The initial and boundary conditions are formulated according to physiology of a hepatocyte cell. The finite volume approach is used for simulation on MATLAB to obtain numerical results. The results are used to analyze the effect of advection, diffusion and buffer concentration on calcium profiles in a hepatocyte cell.

Key-Words / Index Term :
Calcium, Advection, Diffusion, Hepatocyte cell, Finite Volume Method

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